Medicament compound containing hyaluronic acid and beta-aescine sodium

A technology of sodium aescinate and hyaluronic acid, applied to tissue swelling, a pharmaceutical composition containing hyaluronic acid and sodium β-escinate, the application field of medicine, can solve articular cartilage damage, increase joint puncture Infection probability and other issues, to achieve the effect of delaying the curative effect, quick onset of effect, and reducing complications

Inactive Publication Date: 2010-09-08
INST OF BIOPHARM OF SHANDONG PROVINCE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, for patients with obvious joint swelling and effusion, hormones need to be added to reduce the exudation of joint fluid, but hormones have obvious damage to articular cartilage and increase the risk of joint puncture infection

Method used

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  • Medicament compound containing hyaluronic acid and beta-aescine sodium
  • Medicament compound containing hyaluronic acid and beta-aescine sodium
  • Medicament compound containing hyaluronic acid and beta-aescine sodium

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-6

[0015] Composition and dosage

[0016] It can be obtained by subpackaging according to well-known conventional methods. When used, it can be injected directly into the joint cavity.

Embodiment 7

[0017] Example 7: Prepare a solution for intra-articular injection from the hyaluronic acid and β-escin sodium pharmaceutical composition of the present invention, and its usage and dosage are: 0.3 g of sodium hyaluronate, 0.3 g of sodium phylloside and the rest are phosphate buffer solution at pH 7.4, which are prepared and packaged according to known conventional methods. It can be directly injected into the joint cavity when used.

Embodiment 8

[0018] Example 8: Prepare an emulsion for intra-articular injection from the pharmaceutical composition of hyaluronic acid and β-escin sodium according to the present invention. 0.2 grams of sodium, 0.1 grams of lecithin, 0.3 grams of vitamin E, 0.1 grams of Tween 80, and the rest are phosphate buffer solution with a pH of 7.4, which are prepared and packaged according to known conventional methods. It can be directly injected into the joint cavity when used.

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Abstract

The invention provides a medicament compound containing hyaluronic acid and beta-aescine sodium and application thereof in preparing medicaments for treating diseases of osteoarthritis and the like. The compound can play the function of the hyaluronic acid for treating osteoarthritis and the function of the beta-aescine sodium for resisting inflammation and free radicals. In addition, used as an inhibitor of hyaluronidase, the beta-aescine sodium can delay the degradation of the hyaluronic acid by the hyaluronidase, thereby the curative effect is remarkably delayed and improved, and the occurrence of complications is reduced.

Description

[0001] The invention provides a new use of beta-escin sodium intra-articular injection for treating osteoarthritis, a pharmaceutical composition containing hyaluronic acid (also known as hyaluronic acid) and beta-escin sodium, and the composition Application in the preparation of medicines for treating diseases such as osteoarthritis. Background technique [0002] β-Aescin sodium is a saponin sodium salt extracted from the ripe and dry fruit of the Aescinaceae plant, Tianshi chestnut. It is rich in multi-enzyme tendon triterpene saponins, and its composition is clear. At present, the clinical application is mainly intravenous injection, which has high safety. A large number of clinical and pharmacological experiments have proved that its pharmacological effects are as follows: ①Effectively scavenge free radicals and resist cell apoptosis. ②Increase the secretion of prostaglandin F2α; antagonize prostaglandin E1, bradykinin and serotonin and other inflammatory mediators, and i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/728A61K31/704A61P19/02
Inventor 刘文广凌沛学陈建英李鹏
Owner INST OF BIOPHARM OF SHANDONG PROVINCE
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