Composition with anti-tumor effect and application thereof in preparing medicament for treating tumor

An anti-tumor effect and anti-tumor drug technology, applied in the field of medicine, can solve the problem of unresolved fatal cardiotoxicity of toad venom and exacerbate the cardiotoxicity of toad venom, and achieve strong inhibitory effect, safe use, and scientific and reasonable ratio
CN101822832BInactive Publication Date: 2012-09-05NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
Publication Date
2012-09-05
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a composition with anti-tumor effect and application thereof. The composition consists of 0.01 to 10 weight parts of pure bufadienolide compound, extract rich in bufadienolide compound, raw toad venom or toad skin and 0.01 to 99.9 weight parts of medicament with anti-arrhythmic effect. The composition with the anti-tumor effect has the advantage that the match among the components is scientific and reasonable; multiple in vitro tumor cytotoxicity and in vivo tumor inhibiting experiments show that the composition provided by the invention has good anti-tumor effect and plays a role in synergy after combination; and cardiotoxic experiments show that the cardiotoxicity of the composition provided by the invention is obviously reduced, and the composition can reduce thecardiotoxicity caused by primary single use of the bufadienolide compound, the toad venom or the toad skin and plays a role in detoxifying. Therefore, the composition is safer and more effective to use, and is expected to develop a new generation anti-cancer medicament.
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Description

technical field

[0001] The invention relates to a medicine, and specifically designs an antitumor composition with bufasteroids as active components and the application of the composition in preparing medicines for treating tumors. Background technique

[0002] Malignant tumor is a disease with a high mortality rate. According to statistics, there are 2 million new cancer cases in my country every year, and 1.4 million deaths due to cancer. Among the 5 deaths of Chinese residents, 1 person died of cancer. At present, the main methods of tumor treatment include surgery, radiotherapy, chemotherapy, biological therapy, and endocrine therapy, etc., but Western medicine treatment has serious adverse reactions and is expensive.

[0003] Toad Su, a traditional Chinese medicine, is a white slurry secreted by the back-auricular glands and skin glands of the bufo family Bufo bufo or black-orbited toad, which is processed and dried. Toad skin is the skin of Bufoidae animals, such as t...

Claims

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