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Porous biodegradable stent and preparation method thereof

A biodegradable and biodegradable technology, applied in the field of porous biodegradable scaffolds and their preparation, can solve problems such as failure to realize commercialization, and achieve a non-immune rejection, high continuity, and good biodegradability. Effect

Inactive Publication Date: 2010-09-22
四川合泰新光医药有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0018] The method described above is to manufacture a three-dimensional polymer scaffold that can induce cell attachment and differentiation, but there are still many problems in the method of using degradable polymers to manufacture three-dimensional scaffolds for tissue regeneration
In the field of tissue engineering, except for the small-scale PGA suture manufacturing method, it has not been commercialized

Method used

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  • Porous biodegradable stent and preparation method thereof
  • Porous biodegradable stent and preparation method thereof
  • Porous biodegradable stent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] (1) At room temperature, dissolve PLGA (75PLA:25PGA) with a molecular weight of 5000 (75PLA:25PGA) at a weight percentage of 20:80 in an organic solvent prepared from dichloromethane for 2 hours to form a highly viscous solution;

[0040] (2) Add sodium chloride according to the weight ratio of sodium chloride to biodegradable polymer at 1:5, stir uniformly at room temperature, and mix and stir for 1 minute to form biodegradable polymer, organic solvent and chlorine Then quickly fill the paste mixture into a plastic mold and press 345 kPa for 10 minutes to form a semi-finished product;

[0041] (3) Dry the semi-finished product at 29°C for 24 hours to remove the organic solvent to form a molded product;

[0042] (4) Use purified water to continuously remove sodium chloride from the molded product for 30 hours, resulting in a sodium chloride concentration of less than 3 μg / ml;

[0043] (5) After removing sodium chloride, put the molded product into an ultra-low temperature stora...

Embodiment 2

[0046] (1) At room temperature, dissolve PLGA (65PLA:35PGA) with a molecular weight of 200,000 at a weight percentage of 30:70 in an organic solvent prepared from dichloromethane and acetone at a weight percentage of 50:50 for 2.5 hours to form a high Viscous solution

[0047] (2) Add potassium chloride according to the weight ratio of potassium chloride to biodegradable polymer at 1:10, stir uniformly at room temperature, and mix and stir for 2 minutes to form biodegradable polymer, organic solvent and chlorine The paste mixture of potassium sulfide is then quickly filled into the plastic mold and pressed at 414 kPa for 9 minutes to form a semi-finished product;

[0048] (3) Dry the semi-finished product at 28°C for 30 hours to remove the organic solvent to form a molded product;

[0049] (4) Use purified water to continuously remove potassium chloride from the molded product for 24 hours, resulting in a potassium chloride concentration of less than 3 μg / ml;

[0050] (5) After remov...

Embodiment 3

[0053] (1) At room temperature, dissolve PLGA (50PLA:50PGA) with a molecular weight of 350,000 at a weight percentage of 35:65 in an organic solvent prepared from acetone for 3 hours to form a highly viscous solution;

[0054] (2) Add potassium nitrate according to the weight ratio of potassium nitrate to biodegradable polymer at 1:15, stir uniformly at room temperature, and mix and stir for 2 minutes to form a biodegradable polymer, organic solvent and potassium nitrate Paste mixture, then quickly fill the paste mixture into a plastic mold, press 483 kPa for 8 minutes to form a semi-finished product;

[0055] (3) Dry the semi-finished product at 27°C for 35 hours to remove the organic solvent to form a molded product;

[0056] (4) Use purified water to continuously remove potassium nitrate from the molded product for 48 hours, resulting in a potassium nitrate concentration of less than 3 μg / ml;

[0057] (5) After removing potassium nitrate, put the molded product into an ultra-low te...

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Abstract

The invention discloses a porous biodegradable stent and a preparation method thereof. The porous biodegradable stent mainly consists of a biodegradable polymer. The preparation method of the porous polymer stent comprises the following steps: dissolving the biodegradable polymer in an organic solvent; then stirring the mixture and soluble salt at normal temperature to form paste; pressurizing the paste in a die to form a semi-finished product; drying the semi-finished product; removing the organic solvent and desalting in pure water; and finally preparing the finished product by freeze drying pretreatment and freeze drying. The invention has the advantage that the porous biodegradable stent provided by the invention has the characteristics of good biodegradability, high porosity, specific pore size, high continuity, high ratio of superficial area to volume, histocompatibility, blood compatibility and the like and makes the human body have no foreign body sensation and have no immunological rejection. The invention is suitable for nose augmentation, breast augmentation, face-lifting and the like of the human body and tissue regeneration of tissue organ defect, cartilages of the human body, skeletons, liver, heart valves, ductus cysticus, alimentary canal and the like.

Description

Technical field [0001] The invention relates to a porous biodegradable stent and a preparation method thereof. Background technique [0002] With the development of biomaterials and tissue engineering, tissue engineering products are gradually used in the diagnosis and treatment of clinical diseases, especially in the repair and regeneration of parts of the human body. The first generation of biological materials and tissue engineering products that used organic and inorganic medical materials in the 20th century have extended or improved the lives of more than 20 million people worldwide. According to statistics, one-fifth of people over 65 in the United States need to undergo temporary or permanent organ transplantation. The cost of human organ transplantation worldwide accounts for 8% of medical expenses, and its expenditure is 350 billion U.S. dollars. It is foreseeable that with the development of science and technology, especially the advancement of biotechnology, clinica...

Claims

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Application Information

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IPC IPC(8): A61L27/56A61L27/16A61L27/18A61L27/22A61L27/24
Inventor 崔明杜彦军
Owner 四川合泰新光医药有限公司
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