Liquid medicine filtering membrane and preparation method thereof
A liquid medicine filtration membrane, a technology of filtration membrane, applied in the direction of filtration accessories, chemical instruments and methods, membrane technology, etc., can solve the problems that the flow rate cannot meet the clinical infusion requirements, the flow rate cannot meet the requirements, and the hydrophilicity is good. Good chemical compatibility and biocompatibility, low production cost, and the effect of reducing short-term damage and long-term damage
Active Publication Date: 2010-09-22
WUHAN W E O SCI & TECH DEV
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Problems solved by technology
[0008] Polyamide-based membrane materials: good hydrophilicity, but not acid-resistant, and the flow rate cannot meet the domestic clinical infusion requirements;
[0009] Polyvinylidene fluoride and polyethersulfone filter membranes: high filtration accuracy, usually used for precision liquid medicine filtration below 1 μm, good hydrophilicity, the flow rate cannot meet the domestic clinical infusion requirements, the membrane has a good chemical phase Capacitance and biocompatibility
Method used
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Experimental program
Comparison scheme
Effect test
Embodiment Construction
[0032] The specific implementation manners of the present invention will be described in detail below.
[0033] Step S1: Add 10-20 parts by weight of polyvinylidene fluoride, 70-92 parts by weight of solvent, 3-10 parts by weight of additives, and 2-5 parts by weight of non-solvent in the batching kettle in order, and the material at 20-60 ° C After stirring at the liquid temperature for 24-48 hours, move it into the degassing tank, and strictly control the vacuum degree of the degassing tank, and make the casting liquid after 24-48 hours of degassing.
[0034] Wherein said solvent consists of dimethylformamide (DMF, C3-H7-N-O), dimethylacetamide, dimethylsulfoxide (C2H6OS), hexamethylphosphoramide, N-methylpyrrolidone, triethyl phosphate Any one or any combination of esters and trimethyl phosphate; the non-solvent is water or 10% to 30% ethanol, when mixing, add the non-solvent to the above solvent to make a mixed Solvent; the additive is composed of any one or any combinati...
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The invention discloses a liquid medicine filtering membrane and a preparation method thereof, which relate to the technical field of medical appliance manufacture. The invention mainly aims to provide a precise liquid medicine filtering membrane for transfusion, the filtering precision of which is 2-5mum; and moreover, the liquid medicine filtering membrane has the characteristics of high flow rate, high flux, good hydrophilicity, good chemical compatibility and biocompatibility, small medicine adsorbability and low production cost. In the invention, the preparation is carried out by combining a polyvinylidene fluoride membrane phase conversion method and a membrane material composite technology; the thickness of the prepared liquid medicine filtering membrane is 150-300mu m; the liquid medicine filtering membrane comprises a support membrane the bore diameter of which is 15-30 mu m, and one surface or both surfaces of the support membrane is / are coated with composite membranes the bore diameters of which are 2-5mum.
Description
technical field [0001] The invention relates to the technical field of medical device manufacturing, in particular to a precision liquid medicine filter membrane for infusion and a preparation method thereof. Background technique [0002] As we all know, there are a large number of insoluble foreign particles in the liquid medicine. After these particles enter the human body with the liquid medicine, they will cause various short-term and long-term injuries such as phlebitis and pulmonary granuloma to the human body. However, due to the limitation of filter membrane production technology in China, ordinary infusion sets are still widely used in clinical practice, and the filtration accuracy is above 15 μm, while more than 98% of the particles in the drug are below 10 μm, so there is almost no interception effect. [0003] At present, the accuracy of the precision medicine liquid filtration membranes used in clinical infusion in China is 5 μm and 3 μm, and the membrane materi...
Claims
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IPC IPC(8): B01D69/12B01D67/00A61M5/165
Inventor 罗勇吴其玉杨建利
Owner WUHAN W E O SCI & TECH DEV