Production technique of m-bromofluorobenzene

Abstract

The invention discloses a production technique of m-bromofluorobenzene, which takes o-fluoroaniline as main raw material and produces the m-bromofluorobenzene according to the process route of acetylation, bromination, hydrolysis, diazotization, deamination, water vapor rectification and rectification. The production technique introduces methylene dichloride solvent in the working procedure of acetylation, leads the product solid to be changed into solution which is not needed to be separated and is directly hydrolyzed; and the solvent is distilled out by the heat of neutralization reaction in the hydrolysis process, so that the problems of separation intoxication, low production capacity and low hydrolysis yield can be solved. The production technique of the m-bromofluorobenzene not onlyhas simple working procedure steps, greatly improves the safety and reduces the hurt for the people, but also has high reaction yield and low environmental pollution.

Description

technical field [0001] The invention relates to a compound synthesis method, in particular to a production process of m-fluorobromobenzene. Background technique [0002] M-fluorobromobenzene is a commonly used chemical product with a wide range of applications, mainly used in pharmaceutical and pesticide intermediates. The current production process of m-fluorobromobenzene is that the product after the acetylation reaction is solid and needs to be centrifuged. However, it is very easy to be poisoned by aniline after human contact, and the operation is complicated and the production capacity is small. In addition, the conventional practice is to add sodium hypophosphite solution to the diazotization reaction solution in the diazotization deamination reaction. The reaction is particularly violent, and a large amount of gas is released in an instant. The pressure of the kettle is too high to cause accidents and the reaction efficiency is low. Contents of the invention [000...

AI Technical Summary

Problems solved by technology

The current production process of m-fluorobromobenzene is that the product after the acetylation reaction is solid and needs to be centrifuged, but it is very easy to be poisoned by aniline after human contact, and the operation is complicated and the production capacity is small

In addition, the conventional practice is to add sodium hypophosphite solution to the diazotization reaction solution in the reaction of diazotization deamination. The reaction is particularly violent, and a large amount of gas is released in an instant. The pressure of the kettle is too high to cause accidents and the reaction efficiency is low.

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