Production technique of m-bromofluorobenzene

A production process and a technology for m-fluorobromobenzene are applied in the field of production technology of m-fluorobromobenzene, can solve problems such as low reaction efficiency, complicated operation, easy to cause accidents, etc., achieve simple process steps, high reaction yield, and avoid accidents Effect

Active Publication Date: 2010-09-22
营口兴福化工有限公司
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

The current production process of m-fluorobromobenzene is that the product after the acetylation reaction is solid and needs to be centrifuged, but it is very easy to be poisoned by aniline after human contact, and the operation is complicated and the production capacity is small
In addition, the conventional practice is to add sodium hypophosphite solution to the diazotization reaction solution in the reaction of diazotization deamination. The reaction is particularly violent, and a large amount of gas is released in an instant. The pressure of the kettle is too high to cause accidents and the reaction efficiency is low.

Method used

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  • Production technique of m-bromofluorobenzene
  • Production technique of m-bromofluorobenzene
  • Production technique of m-bromofluorobenzene

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Embodiment Construction

[0022] The present invention will be further explained below in conjunction with specific examples.

[0023] The processing steps of producing m-fluorobromobenzene are as follows:

[0024] (1) Acetylation: Check that the inner wall of the bromination kettle, the stirring, and the sleeve of the thermometer are intact without porcelain drop, and close the valve at the bottom of the kettle. Add 1000kg of water and 800kg of o-fluoroaniline to the kettle, start stirring, and add 4100kg of dichloromethane. Add 875kg of acetic anhydride dropwise between 20 and 30°C, keep the temperature for 0.5h after the addition is complete.

[0025] (2) Bromination: Add 673kg (217L) of bromine dropwise into the bromination kettle at a rate of 15-20L / h, control the temperature of the kettle at 25-30°C, and keep the temperature for 0.5h after the addition is complete. Add 465kg of 27% hydrogen peroxide dropwise into the bromination kettle, control the temperature of the kettle at 25-35°C, after th...

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Abstract

The invention discloses a production technique of m-bromofluorobenzene, which takes o-fluoroaniline as main raw material and produces the m-bromofluorobenzene according to the process route of acetylation, bromination, hydrolysis, diazotization, deamination, water vapor rectification and rectification. The production technique introduces methylene dichloride solvent in the working procedure of acetylation, leads the product solid to be changed into solution which is not needed to be separated and is directly hydrolyzed; and the solvent is distilled out by the heat of neutralization reaction in the hydrolysis process, so that the problems of separation intoxication, low production capacity and low hydrolysis yield can be solved. The production technique of the m-bromofluorobenzene not onlyhas simple working procedure steps, greatly improves the safety and reduces the hurt for the people, but also has high reaction yield and low environmental pollution.

Description

technical field [0001] The invention relates to a compound synthesis method, in particular to a production process of m-fluorobromobenzene. Background technique [0002] M-fluorobromobenzene is a commonly used chemical product with a wide range of applications, mainly used in pharmaceutical and pesticide intermediates. The current production process of m-fluorobromobenzene is that the product after the acetylation reaction is solid and needs to be centrifuged. However, it is very easy to be poisoned by aniline after human contact, and the operation is complicated and the production capacity is small. In addition, the conventional practice is to add sodium hypophosphite solution to the diazotization reaction solution in the diazotization deamination reaction. The reaction is particularly violent, and a large amount of gas is released in an instant. The pressure of the kettle is too high to cause accidents and the reaction efficiency is low. Contents of the invention [000...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C25/13C07C17/35
Inventor 刘文波郭振伟
Owner 营口兴福化工有限公司
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