Method for preparing dihydroquercetin from larches

A technology of dihydroquercetin and larch, applied in the direction of organic chemistry, can solve the problems of high cost of column chromatography and long production cycle, and achieve the effects of low production cost, avoiding degradation and high efficiency

Inactive Publication Date: 2010-10-06
NORTHEAST FORESTRY UNIVERSITY +1
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Problems solved by technology

The column chromatography used in this met

Method used

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Embodiment

[0023] Add 1 liter of 50% ethanol solution to 105 g of larch wood chips with a water content of 9.6%, reflux at 80°C for 4 hours, cool and filter, the concentration of dihydroquercetin in the filtrate is about 0.017 mg / mL, add 10 g of 201×7 strong acid cation exchange Resin, then add an equal volume of 1,2-dichloroethane to heat and hydrolyze at 80°C for 2 hours, cool down after the reaction, separate the 1,2-dichloroethane phase, recover 1,2-dichloroethane to obtain a liquid viscous The product is 2.56g, and the content of dihydroquercetin is 32.6%.

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Abstract

The invention relates to a method for preparing dihydroquercetin from larches, which is characterized by comprising the following steps: carrying out reflux extraction on larch wood flour as raw material by using an alcohol solution for one time and filtering to obtain an extraction liquid; adding strong acid ion exchange resin and a chlorinated solvent to the extraction liquid; carrying out reflux hydrolysis to convert bound dihydroquercetin into free dihydroquercetin; separating a chlorinated solvent phase after the reaction is ended; concentrating to dryness; and recrystallizing to obtain the product. The operation process is mainly characterized in that the energy consumption is less, the hydrolysis and the extraction are simultaneously completed, the production cost is low and the yield is high; the catalytic hydrolysis process of the strong acid ion exchange resin does not generate pollution, and all solvents can be recycled, and thereby, the industrial scale production becomes convenient.

Description

Technical field: [0001] The invention relates to the field of natural product chemistry, in particular to a method for preparing dihydroquercetin from larch, Background technique: [0002] Dihydroquercetin is an important dihydroflavonol compound that exists in nature, also known as vitamin P, and it is a forest source active substance with many important biological activities. The pure product is a light yellow powder with strong anti-oxidation ability and plays a special role in maintaining the function of the human circulatory system. A series of effects such as anti-oxidation, anti-aging, anti-inflammation and anti-diabetes have attracted much attention. [0003] The content of dihydroquercetin in larch is about 0.3-5.7%. Dihydroquercetin was first extracted from the leaves of coniferous plant Chamaecyparis obtusa (Sieb.et Zucc.) Endl. by Japanese scholar Fukui. Aglycones of glucosides. He then studied the distribution of its 3-O-glucoside in coniferous plants and the...

Claims

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Application Information

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IPC IPC(8): C07D311/32C07D311/40
Inventor 祖元刚杨磊祖柏实马春慧黄金明孙震刘婷婷郝婧玮王涵
Owner NORTHEAST FORESTRY UNIVERSITY
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