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Method for converting water solubility for reducing biotoxicity of luminous quantum dot synthesized by organic phase

A biotoxic, luminescent quantum technology, applied in luminescent materials, chemical instruments and methods, nanotechnology, etc., can solve the problems of increasing the dynamic diameter of quantum dots, not reducing biological toxicity, and poor biological adaptability. Adjustable luminous color, wide excitation band, good water solubility

Inactive Publication Date: 2010-10-06
UNIV OF JINAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In view of the above problems, the current main solutions are: one is to directly exchange ligands on the surface of quantum dots, so that a small hydrodynamic diameter can be obtained, but because it is an inorganic material, the biological adaptability is not good, and the biological toxicity is not reduced. Secondly, there are also reports on the use of polymers for this type of surface modification. This method can improve the biocompatibility of quantum dots, but it cannot solve the problem of reducing biotoxicity, and this method leads to larger hydrodynamic diameters of quantum dots ( After coating on 5nm quantum dots, the minimum diameter shown in the literature is 15nm); in addition, in recent years, it has been reported in the literature that SiO 2 layer can significantly reduce the escape of heavy metal ions and reduce biological toxicity, but according to the current research status, SiO 2 The particle size after coating and modification is usually greater than 10nm

Method used

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  • Method for converting water solubility for reducing biotoxicity of luminous quantum dot synthesized by organic phase
  • Method for converting water solubility for reducing biotoxicity of luminous quantum dot synthesized by organic phase
  • Method for converting water solubility for reducing biotoxicity of luminous quantum dot synthesized by organic phase

Examples

Experimental program
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Embodiment 1

[0041] 1.1 Synthesis of CdSe quantum dots by organic method (see J.Phys.Chem.C, 2010, 114, 6205-6215 for details): First, put 500 mg of cadmium oxide, 2 g of dioctylamine, and 2 g of nonanoic acid in a three-necked flask Mix, keep vacuum at 100 degrees Celsius for 15 minutes, then heat to 200 degrees Celsius under nitrogen protection to dissolve cadmium oxide, then reduce to 120 degrees Celsius, put 10g of selenium in trioctylphosphine (TOP) solution (the mass concentration of selenium is 10% ) into quickly, in order to control the luminescent color, the growth time is 10 minutes, after separation, washing, and finally dispersed in toluene solution.

[0042] 1.2 Coating ZnS shell on the surface of CdSe quantum dots (see J.Phys.Chem.C, 2010, 114, 6205-6215 for details): newly prepared CdSe quantum dot toluene solution 4mL (quantum dot concentration 0.01mg / mL), Dioctylamine 2g, mixed with 0.05g dimethyl zinc (dissolved in 2mL trioctylphosphine (TOP)), then heated to 60 degrees C...

Embodiment 2

[0045] 2.1 Except that the growth time of quantum dots is 20 minutes, other steps and parameters are the same as in Example 1.1.

[0046] 2.2 Coating ZnS shell on the surface of CdSe quantum dots (see J.Phys.Chem.C, 2010, 114, 6205-6215 for details): newly prepared CdSe quantum dot toluene solution 4mL (quantum dot concentration 0.01mg / mL), Dioctylamine 2g, mixed with 0.07g dimethyl zinc (dissolved in 2.2mL trioctylphosphine (TOP)), then heated to 60 degrees Celsius, the TOP solution of 10g sulfur (the mass concentration of sulfur is 10%) Rapid injection, in order to control the luminescent color, the growth time is 0.8 hours. After the growth is completed, the unreacted liquid reactant is washed away with methanol, centrifuged, and then extracted with toluene to obtain CdSe / ZnS with an average particle size of 7.1nm. Dotted toluene solution.

[0047] 2.3 Dilute 0.5 mL of the newly synthesized CdSe / ZnS quantum dot toluene solution (quantum dot concentration 0.5 mg / mL) into 2 ...

Embodiment 3

[0049] 3.1 The preparation method of CdSe / ZnS core-shell quantum dots is the same as that in Examples 1.1 and 1.2 above.

[0050] 3.2 Dilute 0.5 mL of the newly synthesized CdSe / ZnS quantum dot toluene solution (quantum dot concentration 0.5 mg / mL) into 2 mL of toluene, add 2 μL of methyl orthosilicate, and stir for 3 hours to obtain solution A; 1 μL of trimethyl Aminopropylsilane was added to a mixture containing 25ml of ethanol, 2mL of ammonia water with a mass concentration of 25%, and 1mL of water and stirred for 10 minutes to obtain solution B; mixed and stirred for 2 hours, and then centrifuged at 22000rpm After 20 minutes, the precipitate was dispersed in water to obtain water-soluble, amino-modified, SiO 2 Coated CdSe / ZnS quantum dots. The quantum dots can be connected with carboxyl groups on biomolecules by linking molecules for biomarking.

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Abstract

The invention discloses a method for converting water solubility for reducing biotoxicity of a luminous quantum dot synthesized by an organic phase, which comprises the following steps of: dispersing the quantum dot into an organic solvent, then adding a silane reagent without a functional group into the solvent, allowing the silane reagent to be exchanged with a ligand on the surface of the quantum dot, wherein the concentration of the quantum dot in the organic solvent is 0.03 to 1.0mg / mL; preparing aqueous phase solution with a hydrophilic functional group; and mixing the quantum dot organic solvent and the aqueous phase solution with stirring to perform reaction to transfer the quantum dot to the aqueous phase solution. By using the converting method, the water-soluble quantum dot which is coated with a functionalized SiO2 outer shell, and has low biotoxicity and the diameter of less than or equal to 10nm is obtained; and the quantum dot has the characteristics of high biological adaptability, high fluorescence quantum efficiency, wide excitation band, narrow luminous spectrum, adjustable emitting color and the like.

Description

Technical field: [0001] The invention relates to a water-soluble conversion method capable of reducing the biotoxicity of organic phase-synthesized luminescent quantum dots, in particular to a water-soluble SiO with biologically suitable functional groups covered on the surface of organic-phase-synthesized semiconductor quantum dots 2 Conversion methods for nanomembranes. Background technique [0002] Luminescent semiconductor nanocrystals, also known as quantum dots, have shown important applications in the fields of biology and medicine due to their unique optical and electrical properties. Luminescent semiconductor quantum dots have a wide excitation band and a narrow emission spectrum. By changing the diameter of the quantum dots, a single excitation wavelength can be used to obtain continuously adjustable luminescence from visible to near-infrared, and the quantum dots show good light emission. Stability and high resistance to light fading. Considering the application...

Claims

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Application Information

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IPC IPC(8): C09K11/02C09K11/88C09K11/70B82B3/00
Inventor 杨萍张爱玉曹永强程新
Owner UNIV OF JINAN
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