Skin anti-aging composite nano emulsion and preparation method thereof

Abstract

The invention provides a skin anti-aging composite nano emulsion and preparation method thereof. The nano emulsion has small grain diameter, homogeneous distribution and good transparency and fluidity, anti-aging functional component therein is carried by and matched with high efficiency percutaneous transmission system and empty nano emulsion with passive targeting action and can be rapidly dispersed and solubilized and is instant, and coordination and synergism between composite functional components are enhanced and optimal bio-availability and action effect can be achieved; and functional component percutaneous absorption action can be obviously sped up, thus skin anti-aging short term and long term effects are obvious and lasting. The nano emulsion prepared by applying the invention also effectively improves solubility and dispersity of functional component and improves product stability, safety, practicability and effectiveness. The invention has simple preparation process, requires no special apparatus or precious equipment and requires no heating or other energy, and energy source is saved, thus being beneficial to environmental protection, being easy to industrialization and being capable of being widely applied to beauty care and skin anti-ageing.

Description

technical field [0001] The invention belongs to the technical fields of skin medicine for external use, skin anti-aging and beauty cosmetics, and relates to a skin anti-aging composite nano-emulsion preparation for external use on the skin or face and a preparation method thereof. Background technique [0002] Aging is a gradual process of functional and organic decline of body organs and tissues over time, and is a series of complex biological processes. It is a natural law in the growth process of the body, involving every tissue and organ in the body. This degenerative change can be attributed to the result of endogenous and combined effects of repeated exposure of the individual to various harmful factors in the environment. Skin is an important organ covering the surface of the human body, consisting of epidermis, dermis, subcutaneous tissue and skin appendages (including sweat glands, sebaceous glands, hair and nails, etc.). The skin is not only one of the largest or...

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Problems solved by technology

Therefore, it is necessary to protect the activity and content of those functional ingredients that are not resistant to heat and are afraid of high temperature, especially the protection of active substances such as proteins, peptides, enzymes, and cell growth factors is of great value, and it is important to improve the stability of protein polypeptide drugs or functional ingredients It can maintain its biological activity and biological effect to the maximum extent, while common dosage forms cannot solve the problem of the stability of functional ingredients; (3) Many anti-aging effects come from natural drug extracts, and these extracts are not soluble in water It is also difficult to dissolve in the oil phase. When it is formulated into ordinary preparations, many functional ingredients are not really dissolved, but only in a dispersed state. Its bioavailability is low, and the anti-aging effect is actually difficult to maximize its advantages. Seriously affect the anti-aging effect of its skin; therefore, it is necessary to effectively solve the problem of solubilization, solubilization and instant dissolution of anti-aging functional ingredients; (4) Some anti-aging functional ingredients are not stable to light, such as antioxidants and coenzyme Q10 and other raw materials It is easy to decompose when exposed to light, relatively unstable, and the drug content decreases significantly under light conditions. Therefore, it is necessary to try to wrap these components in a certain carrier preparation milk core to form a relatively stable structure and exert a good effect; ( 5) Skin aging is a complex biological process, which is caused by a variety of factors or the result of their joint participation. Therefore, multiple anti-aging ingredients must play their respective advantages at the same time or synergistically to achieve better results. However, many skin Anti-aging products for external use have a single component, and it is difficult to achieve synergy and joint synergy in practice; (6) The compounding of skin anti-aging functional ingredients often needs to be scientifically formulated in accordance with internal laws and anti-aging laws, such as It needs skin nutrition conditioning, moisturizing to reduce skin water loss, anti-oxidation and scavenging oxygen free radicals, preventing photoaging, improving dynamic wrinkles and physiological wrinkles, regulating the proliferation of new epidermal cells, and improving skin microcirculation. However, the current skin Anti-aging preparations have not yet been found to consider the above-mentioned regulation mechanism, so the actual skin anti-aging effect is also extremely limited