Skin anti-aging composite nano emulsion and preparation method thereof

An anti-aging and emulsion technology, applied in skin care preparations, pharmaceutical formulations, cosmetic preparations, etc., can solve the problem of difficulty in achieving synergy and synergy, and low light stability of anti-aging functional ingredients. , can not solve problems such as the stability of functional ingredients, and achieve the effect of improving bioavailability, increasing the strength of drug action, and saving raw materials

Inactive Publication Date: 2010-11-03
董萍 +1
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  • Abstract
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Problems solved by technology

Therefore, it is necessary to protect the activity and content of those functional ingredients that are not resistant to heat and are afraid of high temperature, especially the protection of active substances such as proteins, peptides, enzymes, and cell growth factors is of great value, and it is important to improve the stability of protein polypeptide drugs or functional ingredients It can maintain its biological activity and biological effect to the maximum extent, while common dosage forms cannot solve the problem of the stability of functional ingredients; (3) Many anti-aging effects come from natural drug extracts, and these extracts are not soluble in water It is also difficult to dissolve in the oil phase. When it is formulated into ordinary preparations, many functional ingredients are not really dissolved, but only in a dispersed state. Its bioavailability is low, and the anti-aging effect is actually difficult to maximize its advantages. Seriously affect the anti-aging effect of its skin; therefore, it is necessary to effectively solve the problem of solubilization, solubilization and instant dissolution of anti-aging functional ingredients; (4) Some anti-aging functional ingredients are not stable to light, such as antioxidants and coenzyme Q10 and other raw materials It is easy to decompose when exposed to...

Method used

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Embodiment Construction

[0057] Formula and preparation method of skin anti-aging composite nanoemulsion preparation.

[0058]The optimal weight ratio of the raw materials of the skin anti-aging composite nanoemulsion preparation is: isopropyl myristate 7.175, caprylic capric acid macrogolglyceride 29.625, polyglycerol fatty acid ester 9.875, triple distilled water 41.888, hexapeptide 0.021, Superoxide dismutase (SOD) 0.001, L-ascorbic acid-2-glucoside (AA2GTM) 2.125, hydroxyethyl carbonamide (BSJ15) 2.5, disodium ethylenediaminetetraacetic acid (EDTA-2NA) 0.125, citric acid 0.09 , sodium citrate 2, N-acetylcysteine ​​1.25, vitamin E 0.875, coenzyme Q100.875, seabuckthorn oil 0.875, azone 0.7.

[0059] The preparation method of skin anti-aging composite nanoemulsion preparation (taking the preparation of 100g as an example):

[0060] ①First prepare 500PPM hexapeptide compound solution: dissolve 0.021g hexapeptide in 41.888g triple distilled water, add 0.001g SOD, 0.125g EDTA-Na2, 0.09g citric acid, 2...

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Abstract

The invention provides a skin anti-aging composite nano emulsion and preparation method thereof. The nano emulsion has small grain diameter, homogeneous distribution and good transparency and fluidity, anti-aging functional component therein is carried by and matched with high efficiency percutaneous transmission system and empty nano emulsion with passive targeting action and can be rapidly dispersed and solubilized and is instant, and coordination and synergism between composite functional components are enhanced and optimal bio-availability and action effect can be achieved; and functional component percutaneous absorption action can be obviously sped up, thus skin anti-aging short term and long term effects are obvious and lasting. The nano emulsion prepared by applying the invention also effectively improves solubility and dispersity of functional component and improves product stability, safety, practicability and effectiveness. The invention has simple preparation process, requires no special apparatus or precious equipment and requires no heating or other energy, and energy source is saved, thus being beneficial to environmental protection, being easy to industrialization and being capable of being widely applied to beauty care and skin anti-ageing.

Description

technical field [0001] The invention belongs to the technical fields of skin medicine for external use, skin anti-aging and beauty cosmetics, and relates to a skin anti-aging composite nano-emulsion preparation for external use on the skin or face and a preparation method thereof. Background technique [0002] Aging is a gradual process of functional and organic decline of body organs and tissues over time, and is a series of complex biological processes. It is a natural law in the growth process of the body, involving every tissue and organ in the body. This degenerative change can be attributed to the result of endogenous and combined effects of repeated exposure of the individual to various harmful factors in the environment. Skin is an important organ covering the surface of the human body, consisting of epidermis, dermis, subcutaneous tissue and skin appendages (including sweat glands, sebaceous glands, hair and nails, etc.). The skin is not only one of the largest or...

Claims

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Application Information

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IPC IPC(8): A61K8/06A61K8/97A61K8/85A61Q19/08
Inventor 杨永鹏朱晓亮董萍丁宇左夏林丁克祥
Owner 董萍
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