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Ibuprofen-containing medicinal composition for injection

A technology for injection and composition, which is applied in the field of pharmaceutical compositions containing ibuprofen, can solve problems such as life-threatening, hemolysis of patients, and inability to use injections in products, and achieves improved solubility, safe administration, and increased content ratio. Effect

Active Publication Date: 2010-11-24
JILIN SIHUAN PHARM CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Once the ibuprofen is insufficiently dissolved, the product cannot be used for injection; if it is injected into the patient without detection, it will cause severe hemolysis and even life-threatening

Method used

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  • Ibuprofen-containing medicinal composition for injection
  • Ibuprofen-containing medicinal composition for injection
  • Ibuprofen-containing medicinal composition for injection

Examples

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Embodiment

[0022]

[0023] Remark:

[0024] (1) The ibuprofen described in the table is (R, S)-ibuprofen or (S)-ibuprofen.

[0025] (2) The basic amino acid described in the table is arginine or lysine or a mixture of the two.

[0026] (3) The arginine mentioned in the table is L-arginine or D-arginine or L, D-arginine.

[0027] (4) The lysine mentioned in the table is L-lysine or D-lysine or L, D-lysine.

[0028] (5) The antioxidant described in the table is selected from any one of the following: sodium sulfite, sodium bisulfite, sodium metabisulfite, ascorbic acid, sodium thiosulfate.

[0029] (6) The metal chelating agent mentioned in the table is edetate disodium or edetate calcium disodium.

[0030] The preparation method of above-mentioned embodiment:

[0031] The basic amino acid is dissolved in water or in an aqueous solution containing antioxidants and metal ion chelating agents, and the ibuprofen is dissolved in the basic amino acid solution to form a basic amino acid a...

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Abstract

The invention relates to an ibuprofen-containing medicinal composition for injection. The medicinal composition is suitable for diminishing inflammation, easing pain and abating fever, and also can be applied to other diseases which can be relieved by ibuprofen. The medicinal composition comprises basic amino acid and ibuprofen and is characterized in that the molar ratio of the basic amino acid to the ibuprofen is 1:1-10:1. The medicinal composition has the advantages of improving the dissolubility of the ibuprofen, stabilizing the performance of the medicinal composition and obtaining safe use for a patient by improving the basic amino acid content of the medicinal composition.

Description

technical field [0001] The invention relates to an injectable pharmaceutical composition containing ibuprofen, which is suitable for anti-inflammatory, analgesic and antipyretic, and can also be applied to other diseases that ibuprofen can relieve. Background technique [0002] Ibuprofen, also known as ibuprofen, is a non-selective cyclooxygenase inhibitor. Its chemical name is (+ / -)-2-(p-isobutylphenyl)propanoic acid, C 13 h 18 o 2 , the molecular weight is 206.3, and the chemical structural formula is as follows: [0003] [0004] Ibuprofen is a chiral compound, clinically used is a mixture of left-handed (R) and right-handed (S) isomers, and the active ingredient of its clinical effect is (S)-ibuprofen, while the left-handed form does not Has pharmacological activity. Similar to many propionic acid derivatives, (R)-ibuprofen can be slowly partially converted to (S)-ibuprofen (about 60%) in the adult human body, acting as a reservoir of active substances and mainta...

Claims

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Application Information

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IPC IPC(8): A61K31/192A61K47/18A61K9/08A61P29/00
Inventor 郭艳丽樊根遥田建宣郭永斌赵婧孙立亚孙煦文高晶康丽霞闫锦凤
Owner JILIN SIHUAN PHARM CO LTD
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