Piperacillin-sulbactam sodium medicinal composition liposome injection

A technology of piperacillin sodium sulbactam sodium and cillin sodium sulbactam sodium, which is applied in the field of medicine and can solve the problems of poor stability of sodium sulbactam sodium, unfull appearance of freeze-dried powder injection, and failure to meet the requirements of pharmacy. , to achieve the effect of reducing the risk of medication, the process is practical, and it is conducive to mass production and promotion

Inactive Publication Date: 2010-11-24
HAINAN MEILAN SMITH KLINE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this application has solved the problem of poor stability of piperacillin sodium and sulbactam sodium to a certain extent, the appearance of the prepared freeze-dried powder injection is not full, and even collapsed, which does not meet the requirements of pharmacy
[0007] More importantly, according to the inventor's long-term comparative study, it is found that the key that affects the combination of piperaci...

Method used

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  • Piperacillin-sulbactam sodium medicinal composition liposome injection
  • Piperacillin-sulbactam sodium medicinal composition liposome injection
  • Piperacillin-sulbactam sodium medicinal composition liposome injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1 Preparation of Piperacillin Sodium Sulbactam Sodium Liposome Injection

[0030] Prescription (100 bottles)

[0031] Piperacillin Sodium 200g

[0032] Sulbactam Sodium 50g

[0033] Sitosterol 187.5g

[0034] Octadecylamine 62.5g

[0035] Mannitol 16.6g

[0036] Lactose 8.3g

[0037] Preparation steps:

[0038] (1) Dissolving 187.5g sitosterol and 62.5g octadecylamine in 500ml ethanol, adding a pH value of 6.5 sodium dihydrogen phosphate solution, stirring and mixing the two solutions, and evaporating to remove the organic solvent;

[0039] (2) Dissolve 200g of piperacillin sodium, 50g of sulbactam sodium, 16.6g of mannitol, and 8.3g of lactose in the above solution, stir evenly and ultrasonically treat for 30min, then place it in a high-speed tissue masher (10000rpm) and rotate for 25min , to obtain liposome mother solution;

[0040] (3) The mother liquor is divided into vials, half-pressed, and placed in a freeze dryer for freeze-drying:

[0041] a. P...

Embodiment 2

[0044] Example 2 Preparation of Piperacillin Sodium Sulbactam Sodium Liposome Injection

[0045] Prescription (100 bottles)

[0046] Piperacillin Sodium 100g

[0047] Sulbactam Sodium 50g

[0048] Sitosterol 57.7g

[0049] Phosphatidylethanolamine 92.3g

[0050]Ribosan 11.25g

[0051] Sodium alginate 3.75g

[0052] Preparation steps:

[0053] (1) Dissolving 57.7g sitosterol and 92.3g phosphatidylethanolamine in 400ml isopropanol, adding a phosphate solution with a pH value of 7.3, stirring and mixing the two solutions, and evaporating the organic solvent;

[0054] (2) Dissolve 100g of piperacillin sodium, 25g of sulbactam sodium, 11.25g of riboglycan, and 3.75g of sodium alginate in the above solution, stir evenly and sonicate for 30min, then place in a high-speed tissue masher (10000rpm) Rotate in medium for 20min to obtain liposome mother solution;

[0055] (3) The mother liquor is divided into vials, half-pressed, and placed in a freeze dryer for freeze-drying:

[...

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PUM

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Abstract

The invention discloses piperacillin-sulbactam sodium medicinal composition liposome injection and a preparation method thereof. The liposome injection comprises the following components in part by weight: 4 parts of piperacillin, 1 part of sulbactam sodium, 2.5 to 7.5 parts of liposome carrier and 0.2 to 1 part of freeze-drying supporting agent, wherein the liposome carrier is the combination of the sitosterol and octadecylamine, preferably the combination of the sitosterol and octadecylamine in a weight ratio of 3:1; and the freeze-drying supporting agent is the combination of mannitol and lactose, preferably the combination of the mannitol and lactose in a weight ratio of 2:1; or the liposome injection comprises the following components in part by weight: 2 parts of piperacillin, 1 part of sulbactam sodium, 1.5 to 4.5 parts of liposome carrier and 0.1 to 0.6 part of freeze-drying supporting agent, wherein the liposome carrier is the combination of sitosterol and phosphatidyl ethanolamine, preferably the combination of the sitosterol and phosphatidyl ethanolamine in a weight ratio of 5:8; and the freeze-drying supporting agent is the combination of nucleo-glycan and sodium alginate, preferably the combination of the nucleo-glycan and sodium alginate in a weight ratio of 3:1.

Description

technical field [0001] The invention relates to a piperacillin sodium sulbactam sodium pharmaceutical composition injection and a preparation method thereof, in particular to a liposome injection preparation prepared by using specific auxiliary materials, and belongs to the technical field of medicine. Background technique [0002] Piperacillin is a penicillin-like broad-spectrum antibiotic, which mainly plays a bactericidal effect by interfering with the synthesis of bacterial cell walls. It is mainly used for infections caused by Pseudomonas aeruginosa and various Gram-negative bacilli but is easily produced by bacteria. Drug resistance due to amidase hydrolysis; sulbactam has no antibacterial activity against other bacteria except Neisseriaceae and Acinetobacter, but sulbactam is important for most of the bacteria produced by β-lactam antibiotic resistant strains β-lactamases are irreversibly inhibited. Sulbactam can prevent drug-resistant bacteria from destroying penici...

Claims

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Application Information

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IPC IPC(8): A61K31/496A61K31/43A61K9/127A61P31/04
Inventor 胡建荣
Owner HAINAN MEILAN SMITH KLINE PHARMA
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