Method for forming composite rhBMP-2 elasticity modulus graded porous titanium alloy support rod for femoral head and neck

Abstract

The invention relates to a method for forming a composite rhBMP-2 elasticity modulus graded porous titanium alloy support rod for the femoral head and the neck. Titanium alloy powder is prepared with an electrode induction melting gas atomization method, and the integrated elasticity modulus graded porous titanium alloy support rod consisting of a head part, a body part and a tail part is prepared according to actually measured biomechanical parameters of the femoral head, the neck and a rotor, wherein the head part and the body part are prepared by sintering the titanium alloy powder and pore-forming agents through the adoption of a cold rolling method, the tail part is prepared by directly sintering the titanium alloy powder, and the porous titanium alloy support rod is immersed in a rhBMP-2/gelatin controlled release microsphere solution. The product prepared by the method can simulate the biomechanical properties of the femoral head and the neck of a human body to the utmost extent, thereby being beneficial to the stress transfer between materials and bone tissue interfaces, avoiding poor bone restoration caused by the stress shielding effect; and simultaneously, sustained-release microspheres on which bone induced growth factors (rhBMP-2) are loaded endue the materials per se with good bone conductivity.

Description

technical field [0001] The invention relates to a preparation method of a support rod for treating early-stage avascular necrosis of the femoral head, in particular to a construction method of a rhBMP-2 composite rhBMP-2 elastic modulus gradient porous titanium alloy support rod for the neck of the femoral head. Background technique [0002] Avascular necrosis of the femoral head is a common orthopedic disease in young and middle-aged people. As the disease progresses, 60-80% of patients have to undergo total hip arthroplasty due to femoral head collapse, deformation and traumatic arthritis, which causes great losses to the patients themselves, their families and society. Improper or untimely treatment of femoral head necrosis is the main reason for this consequence. At present, there are many methods to prevent early femoral head necrosis and femoral head collapse, mainly including restrictive weight bearing, intramedullary decompression, free fibula transplantation, and s...

AI Technical Summary

Problems solved by technology

However, this single porous tantalum rod has certain deficiencies: First, although the porous tantalum rod can play a certain role in structural support, it is not designed in consideration of the biomechanical characteristics of the femoral head and neck, and There are obvious differences in the biomechanical properties (especially the elastic modulus) of the proximal femur in the human body, so that regional stress mismatch will inevitably occur, resulting in a stress shielding effect, which will affect the bone repair and reconstruction around the support rod; the second is porous The tantalum rod is only a single porous metal material, which does not have the activity of inducing osteogenesis. It is difficult to use it to repair the diseased femoral head tissue to play a satisfactory repairing effect. Third, the preparation process of the porous tantalum rod is complicated, and there is no such preparation technology in China. , products are completely dependent on imports

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