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Method for recovering metronidazole finished product from industrial waste residue of metronidazole

A technology of industrial waste residue and metronidazole, which is applied in the direction of organic chemistry and the like, and achieves the effects of simple and easy technological operation, low cost and high purity

Active Publication Date: 2010-12-15
SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In the prior art, there has never been a report on the recovery of metronidazole from the industrial waste residue of metronidazole by using the combined process of hot solution leaching and recrystallization

Method used

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  • Method for recovering metronidazole finished product from industrial waste residue of metronidazole
  • Method for recovering metronidazole finished product from industrial waste residue of metronidazole
  • Method for recovering metronidazole finished product from industrial waste residue of metronidazole

Examples

Experimental program
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Effect test

Embodiment 1

[0023] To 100g of metronidazole industrial waste at 40°C, add 30mL of saturated metronidazole in N,N-dimethylformamide solution at room temperature, hot-dissolution leaching reaction for 10min, leachate (filtered filtrate) in Recrystallized at room temperature to obtain 1.40 g of metronidazole product at room temperature of 18°C.

[0024] Recovery rate and product purity measurement: adopt Hitachi L-7000 type high performance liquid chromatograph to detect the content of metronidazole in the metronidazole industrial waste residue and the product that finally obtains, to calculate the recovery rate of the present invention method and the purity of gained product . First, the analyte is treated with analytically pure N,N-dimethylformamide to form a solution, and then diluted to an appropriate metronidazole concentration (0.1g / L-3.0g / L) for sample detection.

[0025] The detection conditions of high performance liquid chromatography are: the mobile phase is methanol (chromatogra...

Embodiment 2-15

[0029] The quality of the industrial waste residue of metronidazole to be recovered in Examples 2-15 is 100g, and the extract solution added is 30mL of N,N-dimethylformamide solution of saturated metronidazole at room temperature. Other conditions and results are listed in in Table 2.

[0030]

Embodiment 16-29

[0032] The mass of industrial waste residue of metronidazole to be recovered in Examples 16-29 is 100g, and the extract solution added is 35mL saturated metronidazole N,N-dimethylformamide solution at room temperature. Other conditions and results are listed in in Table 3.

[0033]

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Abstract

The invention discloses a method for recovering a metronidazole finished product from industrial waste residue of metronidazole, and the technical scheme is as follows: firstly adding solution of an amide solvent of saturated metronidazole at room temperature into the industrial waste residue of the metronidazole with residual heat, leading the metronidazole to be leached from the industrial waste residue of the metronidazole by hot melting, then re-crystallizing leachate at the room temperature, filtering and obtaining a metronidazole solid product. Filtrate after filtration is still the amide solution of the saturated metronidazole at the room temperature, and the solution can be continuously used for recovering the metronidazole from the industrial waste residue of the metronidazole, thereby realizing the recycling. The method has simple process flow and great benefits, can save energy consumption and is applicable to industrial production.

Description

technical field [0001] The method of the invention relates to the technical field of recovery and reuse of pharmaceutical industry waste residues, in particular to a method for recovering metronidazole finished products from metronidazole industrial waste residues. Background technique [0002] With the development of the pharmaceutical industry, pharmaceutical wastewater has become one of the serious sources of pollution. Due to the need to use a variety of raw materials in the pharmaceutical production process, the production process is complicated, the water quality and water volume fluctuate greatly, and the composition of the wastewater is also very complicated. It is difficult to treat. One of the largest industrial wastewater. In particular, antibiotic industrial wastewater in pharmaceutical wastewater is a kind of high-concentration organic wastewater with high chroma, refractory substances and many biological toxic substances. With the acceleration of the globaliza...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D233/94
Inventor 孙杰段小六莫文艳
Owner SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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