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Carrier, kit and surface enhanced Raman spectroscopy analysis method

A Raman spectroscopy and kit technology, applied in the field of surface-enhanced Raman spectroscopy analysis, can solve the problems of inability to use quantitative analysis, unstable Raman signals, low sensitivity, etc., to avoid unstable Raman signals, simple structure, Sensitive effect

Inactive Publication Date: 2012-08-08
BEIJING YINGFENG CAIZHI INVESTMENT CONSULTATION +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to overcome the shortcomings of Raman signal instability, low sensitivity, difficult operation and inability to be used for quantitative analysis in the surface-enhanced Raman spectroscopy method of the prior art, and to provide a method that can make surface-enhanced Raman spectroscopy analysis Raman Carrier with stable signal, high sensitivity, convenient operation and quantitative analysis

Method used

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  • Carrier, kit and surface enhanced Raman spectroscopy analysis method
  • Carrier, kit and surface enhanced Raman spectroscopy analysis method
  • Carrier, kit and surface enhanced Raman spectroscopy analysis method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] This example is used to illustrate the carrier provided by the present invention and the method for performing surface-enhanced Raman spectroscopic analysis using the carrier.

[0056] (1) Make carrier

[0057] The liquid-absorbing layer 13a is placed on the support body 11, and then the porous matrix layer 12 is placed on the liquid-absorbing layer 13a, wherein the support body 11 is 75 mm (length) * 25 mm (width) * 2 mm ( Thick) glass plate, the material of liquid-absorbing layer 13a is the cellulose paper (liquid absorption rate 5) that thickness is 0.5 millimeter, and the material of porous matrix layer 12 is that aperture is 200 nanometers, porosity is 50% and thickness is 0.5 mm of glass fiber membrane. They are closely attached to each other by rolling, and then a reinforcement layer 14 is formed on the porous matrix layer 12. A reinforcing agent solution composed of lithium chloride was added dropwise on a glass fiber membrane with a thickness of 1 micron. Th...

Embodiment 2

[0061] This example is used to illustrate the carrier provided by the present invention and the method for performing surface-enhanced Raman spectroscopic analysis using the carrier.

[0062] (1) Make carrier

[0063] The same method as in Example 1 is used to make the carrier, except that the reinforcing layer 14 is made of 5 microliters of silver nanoparticles (the particle diameter of the silver nanoparticles is 40-80 nanometers, and the preparation method is the same as in Example 1). ) and 2.5 microliters of a reinforcing agent solution composed of lithium chloride with a concentration of 5 mol / liter are added dropwise on a glass fiber membrane, with a thickness of 0.5 micrometers.

[0064] (2) Detection and analysis

[0065] Get 10 microliters concentration and be that the aqueous solution of melamine of 10ppm mixes with 2.5 microliters of lithium chlorides (5 mol / liter), and add on the described carrier, carry out Raman spectrum detection after the liquid is dried rapi...

Embodiment 3

[0070] This example is used to illustrate the carrier provided by the present invention and the method for surface-enhanced Raman spectroscopy using the carrier and its application in the research of traditional Chinese medicine.

[0071] (1) Make as image 3 The carrier shown

[0072] Support body 11 is the glass plate of 75 millimeters (length) * 25 millimeters (width) * 2 millimeters (thickness), and the material of liquid absorption layer 13a is the cellulose paper (liquid absorption rate 5) that thickness is 0.5 millimeters, porous substrate The material of layer 12 is the glass fiber membrane that aperture is 200 nanometers, porosity 50% and thickness is 0.5 millimeter, reinforcement layer 14 is passed by silver nano-particle (the particle diameter of silver nano-particle is 40-80 nanometer by 5 microliters, The preparation method is the same as in Example 1) and 5 microliters of a concentration of 5 mol / liter of sodium chloride is added dropwise to form a reinforcing age...

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Abstract

The invention provides a carrier. The carrier comprises a supporting body (11) and at least one analysis unit, wherein each analysis unit comprises a liquid removing structure, a porous substrate layer (12) and an enhancement layer (14); the porous substrate layer (12) and the enhancement layer (14) are positioned above the liquid removing structure; the liquid removing structure is positioned inthe supporting body (11) or positioned on the surface of the supporting body (11); the enhancement layer (14) is positioned on the surface of the porous substrate layer (12); the liquid removing structure is used for receiving liquid from the porous substrate layer (12); and the enhancement layer (14) is used for enhancing Raman scattering intensity. The invention also provides a kit containing the carrier and a method for performing surface enhanced Raman spectroscopy analysis by using the carrier. The carrier provided by the invention can obviously enhance a Raman scattering signal, has high sensitivity, and can perform quantitative analysis by adding an internal standard substance or external standard substance.

Description

technical field [0001] The present invention relates to a carrier and a kit comprising the carrier. In addition, the present invention also relates to a method for performing surface-enhanced Raman spectroscopic analysis using the carrier and an application of the carrier. Background technique [0002] Any substance is made up of one or more chemical components. Chemical analysis is the method and process of analyzing the chemical structure, composition and quantity of single or complex compounds. Therefore, chemical analysis is of great significance in agriculture, manufacturing, commercial trade, medical care and public health, and people's daily life. Therefore, research on chemical analysis is in full swing. [0003] Raman spectroscopy (RS) and infrared spectroscopy (IR) belong to molecular vibrational spectroscopy, but their mechanisms are different: infrared spectroscopy is the characteristic absorption of infrared light by molecules, while Raman spectroscopy is the ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/65
Inventor 赵珂
Owner BEIJING YINGFENG CAIZHI INVESTMENT CONSULTATION