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Application of pedunculoside in preparing medicine for treating coronary heart disease

A technology with holothrin and coronary heart disease, which is applied in the field of medicine for cardiovascular system diseases, can solve the problems that the process conditions cannot meet the needs of industrialized production, the operation is complicated, and the cycle is long, so as to reduce the area of ​​cerebral infarction and reduce the myocardial oxygen consumption index. , a significant effect

Active Publication Date: 2011-02-02
李超生 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The deficiencies of the prior art are that highly toxic chloroform needs to be degreased and separated by silica gel column chromatography, the output is small, the cycle is long, the cost is high, the operation is complicated, and the process conditions cannot meet the needs of industrial production

Method used

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  • Application of pedunculoside in preparing medicine for treating coronary heart disease
  • Application of pedunculoside in preparing medicine for treating coronary heart disease
  • Application of pedunculoside in preparing medicine for treating coronary heart disease

Examples

Experimental program
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Effect test

Embodiment 1

[0022] Example 1: Rescue 2000 g of Bing Bing coarse powder, extract three times with 6 times of 80% ethanol, extract for 2, 1, and 1 hours respectively, filter, combine the filtrates, concentrate to extract, add 6000 ml of water, heat in a water bath, and stir , stand overnight, filter to get the precipitate and filtrate, add 50-95% ethanol to reflux for extraction, filter, concentrate the filtrate, place, filter, and dry the precipitate to obtain total saponins, add 10-100 times the total saponins The 50-95% ethanol crystallizes to obtain a part of staphyloside. The filtrate was concentrated to 1000ml, allowed to cool to room temperature, filtered, the precipitate was washed three times with an appropriate amount of water, dried, crystallized with 10-50 times the amount of 50-95% ethanol, and another part of the crude crystals of staphyloside was obtained, twice. The obtained tintosides are combined, and recrystallized for several times with 10-100 times the amount of 50-95% ...

Embodiment 2

[0024] Take the aspartoside prepared by the method of Example 1, and adopt the preparation method of the infusion solution known in the art to prepare the aspartate sodium chloride injection and the aspartate glucose injection: the aspartate 40mg, Sodium Chloride 2.25g is made into Peltatin Sodium Chloride Injection, its specification is 500ml, intravenous injection, 1 bottle at a time, once a day; Peltatin 40mg, Glucose 12.5g, made of Peltatin Glycoside Glucose Injection, its specification is 500ml, intravenous injection, 1 bottle each time, once a day.

Embodiment 3

[0025] Example 3: Take 20 g of tintoside prepared according to the method of Example 1, add an appropriate amount of water for injection, adjust the pH value to 7 with sodium carbonate, stir to dissolve, and add an amount equivalent to 10-15% of tintoside. The mannitol for injection is sterilized and filtered, the content is determined, 1000 pieces are divided into 20 mg / piece, and the seal is sealed. Intravenous injection, 40 mg each time, once a day.

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Abstract

The invention discloses application of pedunculoside in preparing a medicine for treating coronary heart disease. An effective dose of pedunculoside and a pharmaceutically acceptable carrier are prepared into the medicine for treating coronary heart disease. The medicine can be pills, oral liquid, injection, instillation, freeze-dried powder, microcapsules, capsules or tablets. The medicine can be used for preventing and treating coronary heart disease and angina pectoris in clinic, and other diseases with other symptoms such as obstruction of qi in the chest, vertigo, short breath, palpitation, chest distress, or pain and the like.

Description

[0001] This application is a divisional application of the invention patent application entitled "Preparation method and application of holloside" and the application number is 200610017186.7 submitted to the State Intellectual Property Office of China on September 19, 2006. technical field [0002] The present invention relates to the field of medicines for cardiovascular system diseases, in particular to the application of tintoside in the preparation of medicines for treating coronary heart disease. Background technique [0003] Jiubiying is the bark of Ilex rotunda Thunb., a plant of the family Ilexaceae, which is mainly produced in Guangxi and Guangdong Province. For colds, tonsillitis, sore throat, acute gastroenteritis, rheumatism and bone pain; external use for bruises, carbuncle furuncle ulcers, traumatic bleeding, burns and scalds. The chemical components mainly contain triterpenoid saponins, flavonoid glycosides, phenols, tannins, etc. The content of saponins is r...

Claims

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Application Information

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IPC IPC(8): A61K31/7024A61P9/06A61P9/10
Inventor 李超生
Owner 李超生
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