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Gamma-linolenate fat emulsion intravenous injection and preparation method thereof

A technology of intravenous injection and linolenic acid ester, which is applied in the field of medicine to achieve the effect of improving dryness

Inactive Publication Date: 2011-02-23
王京南
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are differences in the chemical structures of the two, which lead to differences in the metabolism and physiological functions of the two in the body

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Formula: 200g of refined ethyl γ-linolenate, 12g of medicinal lecithin, 21g of medicinal glycerin, 0.5g of medicinal vitamin E, appropriate amount of dilute sodium hydroxide solution, and add water for injection to 1000ml.

[0047] 1. Prepare the oil phase liquid: take the refined γ-linolenic acid ethyl ester, medicinal lecithin and medicinal vitamin E in the prescribed amount, and under the protection of nitrogen, heat to 80°C and stir to dissolve into the oil phase liquid for later use;

[0048]2. Prepare the aqueous phase liquid: take the medicinal glycerin and water for injection in the prescribed amount and stir evenly to form an aqueous phase liquid for later use;

[0049] 3. Colostrum emulsion: under the protection of nitrogen, under the high-speed stirring of the water phase liquid, slowly drop the oil phase liquid into the water phase liquid. After dripping, use a high-speed shear agitator to colostrumize for 15 minutes;

[0050] 4. Adjust the pH: under stirrin...

Embodiment 2

[0056] Formula: γ-propylene glycol linolenate 200g, medicinal lecithin 8g, poloxamer 5g, medicinal glycerin 20g, hydroxypropyl-β-cyclodextrin 2g, hydroxypropyl methylcellulose 3g, acetic acid Appropriate amount of dilute sodium solution, add water for injection to 1000ml.

[0057] 1. Preparation of oil phase liquid: take the medicinal propylene glycol γ-linolenate in the prescribed amount, add medicinal lecithin and poloxamer, and under nitrogen protection, heat to 80°C and stir to dissolve into an oil phase liquid for later use;

[0058] 2. Preparation of aqueous phase liquid: take the formula amount of hydroxypropyl-β-cyclodextrin and hydroxypropyl methylcellulose, add water for injection and stir to dissolve, then add medicinal glycerin and stir evenly to form an aqueous phase liquid for later use;

[0059] 3. Primary emulsification: Under the protection of nitrogen, under the high-speed stirring of the aqueous phase liquid, slowly drop the oil phase liquid into the aqueous...

Embodiment 3

[0065] Recipe: 200g of γ-linolenic acid triglyceride, 13g of medicinal lecithin, 18g of medicinal glycerin, 5g of hydroxypropyl-β-cyclodextrin, appropriate amount of dilute sodium hydroxide solution, and add water for injection to 1000ml.

[0066] 1. Preparation of oil phase liquid: Take the medicinal refined γ-linolenic acid triglyceride and medicinal lecithin in the prescribed amount, and under the protection of nitrogen, heat to 80°C and stir to dissolve into oil phase liquid for later use;

[0067] 2. Preparation of aqueous phase liquid: take the formula amount of hydroxypropyl-β-cyclodextrin, add it to water for injection and stir to dissolve, then add medicinal glycerin and stir evenly to form an aqueous phase liquid for later use;

[0068] 3. Primary emulsification: Under the protection of nitrogen, under the high-speed stirring of the aqueous phase liquid, slowly drop the oil phase liquid into the aqueous phase liquid. After the addition, use a high-speed shear agitator...

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PUM

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Abstract

The invention provides gamma-linolenate fat emulsion intravenous injection and a preparation method thereof. The preparation method comprises the following steps of: mixing raw materials such as gamma-linolenate, lecithin, glycerin, sterile pure water, an antioxidant, a stabilizer, a pH regulator and the like under the protection of nitrogen, violently stirring and shearing at a high speed to form primary emulsion; and emulsifying by using a high-pressure homogenizer, filtering by using a microporous membrane filter, filling, sealing and sterilizing to obtain the gamma-linolenate fat emulsion intravenous injection, wherein the gamma-linolenate is gamma-methyl linolenate, gamma-ethyl linolenate, gamma-ethylene linolenate, gamma-propylene linolenate or gamma-triglyceride linolenate, and the gamma-linolenic acid content of the injection is over 90 percent. The gamma-linolenate fat emulsion intravenous injection is used for the fields of medical treatment and health and can be used as a nutritional and therapeutic medicament through abenteric intravenous injection administration, intestinal tube feeding or oral administration.

Description

[0001] technical field [0002] The invention belongs to the field of medicine, and relates to a gamma-linolenic acid intravenous injection through fat emulsion and a manufacturing method thereof. The gamma-linolenic acid intravenous injection through fat emulsion is prepared for parenteral intravenous injection; Administered by gavage or orally. The gamma-linolenic acid ester fat emulsion intravenous injection is used for treating diseases such as heart disease, vascular disorder, high blood pressure, diabetes, obesity, premenstrual syndrome, benign breast disease, senile dementia and the like. [0003] Background technique [0004] γ-linolenic acid (Gamma-Linolenic acid, GLA), common name isolinolenic acid, vitamin F, scientific name: Transit 6,9,12-octadecatrienoic acid (Gamma- 6,9,12,-octadecatrienoic acid) , belonging to the omega-6 polyunsaturated fatty acid, there are three conjugated double bonds in the γ-linolenic acid molecule, so it has very strong reducibility...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61P3/04A61P9/12A61P15/00A61P25/28A61P9/00A61P3/06A61K31/232A61P15/14A61K9/107
Inventor 王京南王孝荣
Owner 王京南
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