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Method for producing piperine

A production method and a technology for piperine, which are applied in the field of deep processing of agricultural products, can solve problems such as no extraction of piperine, and achieve the effects of improving separation efficiency and purity, low energy consumption, and improving extraction efficiency.

Inactive Publication Date: 2013-05-01
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But there is no report for extracting piperine

Method used

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  • Method for producing piperine
  • Method for producing piperine

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Experimental program
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Effect test

Embodiment 1

[0030] Embodiment 1 carries out according to the following steps:

[0031] Get 100 kg of dry white pepper and crush it into pepper powder, then use 80 liters of mixed solvent (20 parts of 95% edible alcohol, 10 parts of 1 mol / liter of acetic acid, V / V) to moisten the pepper powder overnight, and use it every 1 hour Spiral stirring was stirred for 5 minutes, and then 200 liters of the above-mentioned mixed solvent was added for static soaking. After 12 hours, the solid phase and the liquid phase in the mixture were separated. Repeat the immersion and separation process 3 times. Combine all extracts and filter by centrifugation or plate and frame filter. Put the filtrate on the D101 macroporous resin column, and put it on the column until piperine just flows out in the effluent. Then wash 3 column volumes with clear water, and then wash 3-4 column volumes with a mixed solvent (80:20, V / V) of ethanol solution composed of 95% edible alcohol and 1 mol / L acetic acid. The collecte...

Embodiment 2

[0033] With the raw material that contains piperine in Table 1 as experimental raw material, extraction solvent is 20 parts of methanol, 10 parts (V / V) of the hydrochloric acid of 1 mol / liter, and all the other steps are with embodiment 1, and experimental result is shown in Table 1.

[0034] Table 1

[0035]

Embodiment 10

[0036] Embodiment 10 carries out according to the following steps:

[0037] Get 300 kilograms of immature pepper young fruits, break into pulp, then use 120 liters of mixed solvent (20 parts per liter of 1 mole hydrochloric acid, 80 parts of 95% edible alcohol) to wet pepper powder overnight, and use mechanical continuous Stir, then add 150 liters of the above mixed solvent for soaking, and separate the solid and liquid phases in the mixture after 12 hours. Repeat the soaking and separating process 3-4 times. Combine all extracts and filter by centrifugation or plate and frame filter. Put the filtrate on the H103 macroporous resin column, and put it on the column until piperine just flows out in the effluent. Then wash 3 column volumes with clear water, and then wash 3-4 column volumes with an ethanol solution (85:15, V / V) composed of 95% edible alcohol and 1 mole of hydrochloric acid per liter. The collected effluent was concentrated in vacuo, and after recovering the alco...

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Abstract

The invention discloses a method for producing piperine, which comprises the following steps of: uniformly mixing an acid solvent and a piperine-containing raw material, allowing leach liquor to flow through an adsorption resin chromatographic column, stopping adding the leach liquor until the piperine is adsorbed to flow out, and eluting the adsorbed piperine by using an eluting solvent; concentrating the piperine eluent in vacuum and recovering an organic solvent to obtain piperine concentrate; dissolving the piperine concentrate, and adding seed crystals for crystallization; and recrystallizing to obtain piperine crystals with the purity of over 98 percent. According to the alkaloid properties of the piperine, the acid organic solvent is used, the dissolubility of the piperine is greatly improved, and the extraction efficiency is improved; the chromatography is used, so the separation efficiency and purity of the piperine are improved, the whole production process is low in energy consumption, and the prepared piperine has high yield and purity; besides, the immature pepper fruits which are always wasted and discarded conventionally are used for extracting the piperine, and sources of raw materials for producing the piperine are increased.

Description

technical field [0001] The invention belongs to the deep processing of agricultural products, and relates to a method for extracting piperine from white pepper, black pepper, young pepper fruits and longan. Background technique [0002] Piperine is a chemical component in pepper, which has unique medicinal effects such as calming the nerves, warming the middle and dispelling cold, appetizing and lowering qi, reducing inflammation, and detoxifying; modern medical research has confirmed that piperine has anti-inflammatory, blood fat-lowering, anti-cancer, and analgesic properties , sedative, antidepressant, insecticidal and other activities. It is one of the necessary ingredients for various drugs in the pharmaceutical industry, and its application value cannot be underestimated in the pharmaceutical industry. Piperine is also a natural insecticide with excellent characteristics such as non-toxic and pollution-free. Piperine is also an important raw material for the productio...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D317/60
Inventor 黄雪松
Owner JINAN UNIVERSITY
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