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Use of sulfated fucan in preparing medicines for treatment of gastrointestinal diseases

A technology of fucoidan and gastrointestinal diseases, which is applied in the application field of fucoidan sulfate in the preparation of drugs for treating gastrointestinal diseases, can solve the problems of no application research or patent of fucoidan sulfate, and achieve no toxic side effects, significant The effect of curative effect

Inactive Publication Date: 2011-03-30
吉林省辉南长龙生化药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After literature search and patent search, no application research or patent of fucoidan sulfate in the treatment of gastrointestinal diseases was found

Method used

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  • Use of sulfated fucan in preparing medicines for treatment of gastrointestinal diseases
  • Use of sulfated fucan in preparing medicines for treatment of gastrointestinal diseases

Examples

Experimental program
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Effect test

Embodiment 1

[0024] Preparation of fucoidan sulfate ester: crush seaweed and soak overnight in 3.7% formaldehyde solution, then add distilled water to boil for extraction, and filter the extract with diatomaceous earth. Concentrate the solution, add ethanol to a concentration of 75% to precipitate, and dry the precipitate to obtain crude fucoidan sulfate. Dissolve the crude product of fucoidan sulfate in water, in 0.05mol / L MgCl 2 In the presence of 20% ethanol precipitation to remove water-soluble alginate, the filtrate is dialyzed, concentrated and then precipitated with 75% ethanol, and dried to obtain purified fucoidan sulfate.

Embodiment 2

[0026] Preparation of fucoidan sulfate ester: crush dry kelp and weigh 1kg, add 0.1mol / L hydrochloric acid solution about 10 times, extract twice, filter cloth to remove extract, and use ultrafiltration ultrafiltration with a molecular weight cut-off of 10- For the 800KD part, use 0.5mol / L sodium hydroxide solution to adjust the pH to 5-7, desalt through ultrafiltration to obtain a concentrated solution, and freeze-dry to obtain light yellow fucoidan sulfate.

Embodiment 3

[0028] Preparation of fucoidan sulfate ester: crush the seaweed and add 20 times distilled water to boil for 3 hours, filter the extract with diatomaceous earth, dialyze the filtrate for one day with tap water, then dialyze with distilled water for one day, concentrate the dialysate, add ethanol to a volume concentration of 75% for precipitation, and the precipitation was dried to obtain crude fucoidan sulfate. The crude product was redissolved in water, in the presence of 0.05mol / L MgCl 20% volume concentration ethanol precipitation to remove water-soluble alginate, the filtrate was dialyzed and concentrated, and the volume concentration was 75% ethanol precipitation, and after drying, purified fucoidan sulfate was obtained. Various seaweed polysaccharide sulfates were prepared according to the above method.

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PUM

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Abstract

The invention relates to a new pharmaceutical use of sulfated fucan, more particularly to a use of sulfated fucan in preparing medicines for the treatment of gastrointestinal diseases. Gastric diseases include gastritis, gastric ulcer, doudenal ulcer, enteritis or colitis. The gastritis include a variety of acute and chronic gastritises such as superficial gastritis, hypertrophic gastritis and the like. The main pharmacodynamics tests of sulfated fucan as gastrointestinal diseases show that sulfated fucan includes particular protective effect for both gastric ulcer induced by ethanol in mice and reserpine gastric ulcer. The preliminary statistics on the clinical treatment results of 50 different patients with gastric disease represents that, 22% of the patients are cured after the administration of sulfated fucan, 40% is effective, 22% is excellent, 16% is ineffective and the total effective rate is 84%, thus the sulfated fucan can obtain remarkable curative effect, has no toxic and side effect and is safe and reliable.

Description

technical field [0001] The invention relates to a new pharmaceutical application of fucoidan sulfate, in particular to the use of fucoidan sulfate in the preparation of medicines for treating gastrointestinal diseases. Background technique [0002] Fucoidan sulfate is a kind of sulfated polysaccharide containing fucose, which exists in brown algae and was first extracted from kelp palmate by Kylin in 1913 with dilute acid. Kylin hydrolyzes the extract to separate L-fucose. Fucoidan sulfate (English name: sulfated fucan, FPS. Alias: fucoidan, fucoidan, fucoidan sulfate, fucoidan, fucoidan) is a kind of sulfated polysaccharide extracted from brown algae. Polysaccharides, mainly composed of fucose (26-32%) and sulfate groups, are highly 3-branched (1-2) or (1-3) linked α-L-fucose-4-sulfate ester. Ingredients source: kelp, brown algae and echinoderms. White flocculent powder. Active ingredient: L-fucose-4-sulfate. Other ingredients: a small amount of galactose, mannose, xy...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/737A61P1/04
Inventor 金铁进
Owner 吉林省辉南长龙生化药业股份有限公司