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Strontium ranelate dry suspension

A dry suspension, strontium ranelate technology, which is applied to non-active ingredients medical preparations, organic active ingredients, bone diseases, etc., can solve the problems of unreachable, poor suspension stability, etc., and improve the dissolution rate , The effect of preventing osteoporosis, the preparation method is simple

Active Publication Date: 2011-04-06
CHONGQING PHARMA RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, Protelos strontium ranelate dry suspension granules have been listed in the domestic market. According to research, its suspension stability is very poor, and it will settle after being suspended in water for a while, which cannot meet the requirements of the Chinese Pharmacopoeia.

Method used

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  • Strontium ranelate dry suspension

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] prescription:

[0018] Strontium ranelate (as anhydrous) 2000g

[0019] Lactose 1000g

[0020] Dextrin 350g

[0021] Stevioside 200g

[0022] Croscarmellose Sodium 130g (3.7%)

[0023] Make 1000 bags

[0024] Preparation process: 1. Strontium ranelate, lactose, dextrin, croscarmellose sodium and steviol glycoside are respectively passed through an 80-mesh sieve for later use. 2. Weigh the prescription amount of raw and auxiliary materials and mix them evenly. 3. The mixed raw and auxiliary materials are made into soft materials with the prepared ethanol solution, granulated, granulated after drying, and the amount can be filled.

Embodiment 2

[0026] prescription:

[0027] Strontium ranelate (as anhydrous) 2000g

[0028] Mannitol 1225g

[0029] Maltodextrin 150g

[0030] Aspartame 20g

[0031] Croscarmellose Sodium 105g (3%)

[0032] Make 1000 bags

[0033] Preparation process: 1. Strontium ranelate, mannitol, maltodextrin, croscarmellose sodium and aspartame are respectively passed through an 80-mesh sieve for later use. 2. Weigh the prescription amount of raw and auxiliary materials and mix them evenly. 3. The mixed raw and auxiliary materials are made into soft materials with the prepared ethanol solution, granulated, granulated after drying, and the amount can be filled.

Embodiment 3

[0035] prescription:

[0036] Strontium ranelate (as anhydrous) 2000g

[0037] Powdered sugar 1015g

[0038] Dextrin 150g

[0039] Aspartame 20g

[0040] Croscarmellose Sodium 315g (9%)

[0041] Make 1000 bags

[0042] Preparation process: 1. Strontium ranelate, powdered sugar, dextrin, croscarmellose sodium and aspartame are respectively passed through an 80-mesh sieve for later use. 2. Weigh the prescription amount of raw and auxiliary materials and mix them evenly. 3. The mixed raw and auxiliary materials are made into soft materials with the prepared ethanol solution, granulated, granulated after drying, and the amount can be filled.

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PUM

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Abstract

The invention belongs to a medicinal preparation and relates to a strontium ranelate-containing dry suspension formulation. The dry suspension consists of 50 to 65 weight percent of strontium ranelate, 20 to 30 weight percent of filler, 3 to 10 weight percent of adhesive, 2 to 10 weight percent of disintegrating agent, 0 to 5 weight percent of flow aid and a proper amount of taste-masked agent. The disintegrating agent is added to be crosslinked with sodium carboxymethylcellulose to accelerate the disintegration, the dissolution rate is obviously improved and the dry suspension can achieve the suspension effect without suspending aid or stabilizing agent.

Description

technical field [0001] The invention belongs to pharmaceutical preparations, in particular to a strontium ranelate dry suspension which improves the suspension effect. For the treatment and prevention of osteoporosis. Background technique [0002] Strontium ranelate is a new drug for the treatment of osteoporosis with a bidirectional mechanism of "increasing bone formation and inhibiting bone resorption", which can restore the dynamic balance of bones and make them stronger. Osteoporosis is a progressive skeletal disease characterized by decreased bone density and changes in bone tissue structure, manifested as increased bone fragility and susceptibility to fractures, and the most common fracture sites are the spine, hip and wrist. Osteoporosis is a common disease. According to statistics, 1 in 3 women and 1 in 8 men will suffer from osteoporosis worldwide. With the extension of human life expectancy, the incidence of osteoporosis and the resulting fractures have increased...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K31/381A61K47/38A61P19/10
Inventor 李佳张涛牟才华
Owner CHONGQING PHARMA RES INST