New application of curcumin

A technology of curcumin and medicine, applied in the field of curcumin, can solve problems such as unproven effects
CN102018689AInactive Publication Date: 2011-04-20PEKING UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
PEKING UNIV
Publication Date
2011-04-20
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses application of curcumin to preparation of medicaments for preventing and / or treating autosomal dominant polycystic kidney disease. A madin-darby canine kidney (MDCK) vesicle model is used for screening to obtain the curcumin which inhibits formation and growth of vesicles. An experimental result shows that: the curcumin has an obvious inhibiting effect on the formation and growth of MDCK vesicles and the effect of the curcumin is in dose response relationship; the curcumin has no cytotoxicity to MDCK cells, so that the vesicle inhibiting effect of the curcumin is independent of the cytotoxicity; the curcumin does not obviously induce MDCK cell apoptosis, so that the vesicle inhibiting effect of the curcumin is independent of cell apoptosis promotion of the curcumin; the curcumin can promote the MDCK cells or vesicles to form tubular structures; and the effect is in dose response relationship; and the curcumin has an inhibiting effect on the growth of the embryonic kidney vesicles. The curcumin is expected to be developed into a specific medicament for preventing and / or treating autosomal dominant polycystic kidney disease.
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Description

technical field

[0001] The present invention relates to a new application of curcumin. Background technique

[0002] 1. The characteristics and pharmacological effects of curcumin

[0003] 1. General characteristics of curcumin

[0004] Curcumin (Curcumin, Cur) is a natural polyphenolic compound extracted from the rhizomes of Curcuma longa, Curcuma longa, Curcuma longa, etc. (its chemical structure is as follows: figure 1 shown). Curcumin is easily soluble in methanol, ethanol, alkali, acetic acid, acetone, dimethyl sulfoxide and other organic solvents, almost insoluble in water, and its molecular formula is C 21 h 20 o 6 , the molecular weight is 368.38, and its main chain is unsaturated aliphatic and aromatic groups. Curcumin has various pharmacological effects such as anti-oxidation, anti-fibrosis, anti-tumor, anti-depression, anti-inflammatory, anti-viral, anti-thrombotic, anti-angiogenic and immune regulation, and has low toxicity. However, the blood concentratio...

Claims

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