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Leukocyte remover for extracorporeal circulation

A technology for extracorporeal circulation and white blood cells, which is applied in blood circulation treatment, gravity filters, chemical instruments and methods, etc. It can solve the problems of removing filter material clogging, difficult to handle blood volume, etc. The effect of performance stabilization

Active Publication Date: 2014-04-02
ASAHI KASEI MEDICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When such agglutinates are formed, when only the leukocyte-removing filter material is used to filter the blood, the leukocyte-removing filter material is clogged due to the agglutinate, and it is difficult for the extracorporeal circulation leukocyte-removing device to process the required amount of blood.

Method used

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  • Leukocyte remover for extracorporeal circulation
  • Leukocyte remover for extracorporeal circulation
  • Leukocyte remover for extracorporeal circulation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～13

[0104] (Examples 1-13, Comparative Examples 1-10)

[0105] Use 15g / m made by spunbond 2 A non-woven fabric made of polyethylene terephthalate is used as a base fabric formed of long fibers, on which 25g / m 2 Short fibers made of polyethylene terephthalate with a fiber length of 50 mm are sprayed on the laminate with a nozzle diameter of 90 μm on the support wire of the hydroentanglement machine at a pressure of 100 kgf / cm 2 of water so that the fibers interweave to give 40g / m 2 Agglomerates formed by spunlace nonwovens remove filter material. In addition, the following substances were used as leukocyte-removing filter materials. Three types of nonwoven fabrics were produced by the meltblown method and used as leukocyte-removing filter materials. 1 type has a fineness of 0.043dtex and a weight per unit area of ​​80g / m 2 A non-woven fabric made of polyethylene terephthalate (filter material X), the other is a fineness of 0.031dtex and a weight per unit area of ​​66g / m 2 non...

Embodiment 14

[0107] One sheet of the polyethylene terephthalate nonwoven fabric (filter material X) used in Example 1 with a size of 25×16 mm was prepared as a leukocyte-removing filter material. Separately prepare a 25×16 mm filter material for removing aggregates. A winding rod made of polypropylene was placed on a nonwoven fabric made of polyethylene terephthalate (filter material X), and wound up. Furthermore, the condensed matter removal filter material was wound on it, and temporarily fixed, and the winding rod was pulled out to make a nonwoven fabric cylinder. One end (A side) of the non-woven fabric cylinder is sealed with epoxy resin so as to be impermeable to liquid, and the other end (B side) is filtered in a cylindrical shape on a polyethylene plate with holes of 2 mm in diameter. A cylindrical rod with an inner diameter of 1.5 mm was inserted into the hole with the central portion of the filter serving as the blood outlet, and the peripheral portion of the filter was sealed w...

Embodiment 15

[0109] The polyethylene terephthalate nonwoven fabric (filter material Y) used in Example 2 of 97×16 mm was prepared as a leukocyte-removing filter material. Separately, a polyethylene mesh of 80×16 mm was prepared. The polyethylene nonwoven fabric (filter material Y) was folded in half at 46:51, and a polyethylene mesh was interposed therebetween. Place a winding rod made of polypropylene on the side of the non-woven fabric that does not expose the mesh, and wrap the non-woven fabric made of polyethylene (filter material Y) and the mesh into a circle by winding the winding rod. Cylindrical. Furthermore, the aggregate-removing filter material used in Example 1 was wound around its outer periphery for 2 turns, temporarily fixed so as not to unwind, and the winding rod was drawn out again. Then, it prepared similarly to Example 14 except having used the cylindrical polyethylene container of 15 mm in diameter and 25 mm in length.

[0110] Determination of elongation (strengt...

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Abstract

The present invention provides a leukocyte remover for extracorporeal circulation, which has the following advantages: easy manufacture, high leukocyte removing performance and capability for treating a large amount of blood. The leukocyte remover for extracorporeal circulation is characterized in that: a filtering layer which is composed of a pre-filtering layer and a main filtering layer is accommodated in a container with a blood inlet and a blood outlet; the pre-filtering layer is composed of an agglutinator removing filtering material for removing the agglutinator which is contained in the blood; the main filtering layer is composed of leukocyte removing filtering material for removing the leukocytes that are contained in the blood; the agglutinator removing filtering material comprises one kind of fiber which has a denier of 0.7dtex-4.0dtex and has a fiber length of 1mm-80mm and bottom cloth that is formed by long fibers with fiber axes that are aligned in a planar direction. Furthermore the short fibers are interwoven on the bottom cloth so the weight in unit area is 10g / m2-80g / m2. The layers of the short fibers form a three-dimensional structure.

Description

technical field [0001] The present invention relates to a leukocyte eliminator for extracorporeal circulation filled with a filter material for efficiently removing leukocytes from peripheral blood. Specifically, it relates to a leukoremover for extracorporeal circulation including a filter material for removing aggregates for efficiently removing aggregates in a large amount of blood ranging from 1 L to 10 L, and a filter material for removing leukocytes. Background technique [0002] For systemic lupus erythematosus, rheumatoid arthritis or malignant rheumatoid arthritis, multiple sclerosis and other autoimmune diseases, or ulcerative colitis, Crohn's disease and other inflammatory bowel diseases, leukemia, cancer, etc. For the purpose of treatment, or for the purpose of immunosuppression before organ transplantation, a technique of removing leukocytes contained in peripheral blood using a leukapheresis for extracorporeal circulation is being developed. [0003] When the ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01D24/08B01D35/00A61M1/36
Inventor 松浦良畅福田达也助川威大石辉彦
Owner ASAHI KASEI MEDICAL CO LTD
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