Medicine for promoting leukopoiesis

A leukocyte and drug technology, applied in drug combination, extracellular fluid diseases, pharmaceutical formulations, etc., can solve the problems of high price, poor efficacy, short-term effect, etc., and achieve the effect of strong applicability, promotion of leukocyte production, and mild adverse reactions.

Active Publication Date: 2011-06-01
SHANXI ZHENDONG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, through years of clinical evaluation of these drugs, it was found that: vitamin B4, batyl alcohol, etc. have poor curative effects; colony-stimulating factors are short-lived, expensive, and can cause side effects such as bone pain and fever; Injections also have corresponding adverse reactions such as dry mouth, nausea and vomiting, which have certain restrictions on the application of this type of drug.

Method used

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  • Medicine for promoting leukopoiesis
  • Medicine for promoting leukopoiesis
  • Medicine for promoting leukopoiesis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Take 5.4Kg of American ginseng and pulverize it into coarse powder, reflux extract twice with 80% ethanol which is 6 times the weight of American ginseng, for 1.5 hours each time, filter, recover ethanol from the filtrate and concentrate to obtain extract 1;

[0031] Take astragalus 15Kg, epimedium 6Kg, angelica 5.4Kg, sealwort 5.4Kg, Eclipta 7.2Kg, medlar 6Kg, psoraleae 5.4Kg, gallispaulis 9Kg and mix with the above-mentioned medicinal dregs after alcohol extraction of American ginseng, add 10 Decoct in water twice the total weight of the drug, each time for 1.5 hours, filter, concentrate the filtrate to a relative density of 1.15 (60°C), add 95% ethanol to an alcohol content of 30%, stir while adding, and Stand still for alcohol precipitation for 24 hours, centrifuge at 3000rpm for 20 minutes, take the supernatant, recover ethanol and concentrate until it has no alcohol smell, and obtain extract 2;

[0032] Combine extract 1 and extract 2, mix evenly, continue to conc...

Embodiment 2

[0035] Take 6Kg of American ginseng and grind it into coarse powder, reflux extract twice with 80% ethanol which is 6 times the weight of American ginseng, for 1.5 hours each time, filter, recover ethanol from the filtrate and concentrate to obtain extract 1;

[0036] Take Astragalus 18Kg, Epimedium 6Kg, Angelica 6Kg, Polygonatum 6Kg, Eclipta 8Kg, Lycium barbarum 6Kg, Psoraleae 6Kg, Gallis Spatholobus 12Kg and mix with the dregs of American ginseng after alcohol extraction, add 10 times the amount of water Decoct twice, each time for 1.5 hours, filter, concentrate the filtrate to a relative density of 1.15 (60°C), add 95% ethanol to an alcohol content of 30%, stir while adding, and let it stand for alcohol precipitation for 24 hours after the addition is complete. Centrifuge at 3000rpm for 20 minutes, take the supernatant to recover ethanol and concentrate until it has no alcohol smell, and obtain extract 2;

[0037] Combine extract 1 and extract 2, mix evenly, continue to con...

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Abstract

The invention discloses a medicine for promoting leukopoiesis, which can be prepared into any one of conventional solid oral preparations by using milk vetch, deerhorn glue, American ginseng, epimedium, angelica, sealwort, eclipta, medlar, fructus psoraleae and spatholobus stem as raw medicines and using conventional methods of traditional Chinese medicine preparations. The medicine disclosed by the invention has the functions of strengthening the spleen and nourishing the kidney, nourishing qi and blood and tonifying yin and yang, can be used for regulating the bone marrow haematopoietic function after radiotherapy and chemotherapy and promoting the leukopoiesis, and is suitable for preventing and treating bone marrow suppression leukopenia after radiotherapy and chemotherapy. The clinical test research shows that the total effective rate of the leukopoiesis is 88.46%.

Description

technical field [0001] The invention relates to a medicine for promoting leukocyte production, in particular to a traditional Chinese medicine for regulating bone marrow hematopoietic function and promoting leukocyte production after radiotherapy and chemotherapy, and belongs to the technical field of Chinese patent medicine preparation. Background technique [0002] In view of the influence of infection, radiation, chemical poisoning, drug application (non-steroidal anti-inflammatory drugs, antineoplastic drugs, antibiotics), especially the main methods such as surgery and radiotherapy and chemotherapy used in the treatment of malignant tumors, the most common adverse effects The response and dose-limiting toxicity was myelosuppression manifested by leukopenia. This will seriously affect the treatment and increase the chance of infection. To this end, bone marrow hematopoietic function should be adjusted in time to promote white blood cell production. [0003] At present,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8969A61P7/00A61K35/32
Inventor 李安平刘丽坤
Owner SHANXI ZHENDONG PHARMA
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