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Method for synthesizing mesoporous silica-based nanocomposite embedded with gold nanorods

A technology of nanocomposite materials and gold nanorods, which is applied in the field of synthesis of mesoporous silicon-based nanocomposites, can solve the problems of high biological toxicity, achieve the effects of ensuring dispersion, ensuring functionalization, and solving biological toxicity

Inactive Publication Date: 2011-06-01
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The purpose of the present invention is to synthesize a monodisperse, stable mesoporous silicon-based nanoparticle and gold nanorod composite structure nanomaterial, that is, a mesoporous silicon-based nanocomposite material inlaid with gold nanorods, so as to overcome the problem of adsorbing the particle surface in the prior art. Problems such as high biological toxicity caused by surfactants and reaction auxiliary catalyst residues

Method used

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  • Method for synthesizing mesoporous silica-based nanocomposite embedded with gold nanorods
  • Method for synthesizing mesoporous silica-based nanocomposite embedded with gold nanorods
  • Method for synthesizing mesoporous silica-based nanocomposite embedded with gold nanorods

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Effect test

Embodiment 1

[0040] (1) Carboxyl functional modification of gold nanorods: A 20 ml aqueous solution of gold nanorods with a concentration of 3.75 mmol / L gold element was synthesized using cetyltrimethylammonium bromide (CTAB) as a dispersant and growth director. . To the obtained gold nanorod sol solution, 2 mg / ml of HOOC-(CH 2 CH 2 O) 7 -S-S-(CH 2 CH 2 O) 7 10 ml of -COOH (CAS Number: 873013-93-5) compound aqueous solution, and then sonicated at 55° C. for 2 hours to obtain a carboxyl-functionalized gold nanorod solution.

[0041] (2) Surface amino functionalization of mesoporous silicon-based nanoparticles: mesoporous silica nanoparticles (Fe 3 O 4 @mSiO 2 ) 20mg was dispersed in 30ml of ethanol, and the added aminotriethoxysilane was 1 / 50 of the molar amount of mesoporous silicon-based nanoparticles, which was not suitable for Fe 3 O 4 @mSiO 2 Modification was carried out, heated under reflux for 5 hours, the obtained reflux product was centrifuged, and then dispersed in wate...

Embodiment 2

[0054] The magnetic mesoporous silicon-based nanocomposites embedded with gold nanorods obtained in Example 1 were ultrasonically dispersed in DMEM cell culture medium, and the concentration of the magnetic mesoporous silicon-based nanocomposites embedded with gold nanorods in the DMEM cell culture medium solution was 80ug / ml, Transfer 100ul of the above solution to a 96-well plate. The composite particle solution was irradiated with an 808 nm table top light source in the vertical direction of the 96-well plate, and the irradiation power and time were adjusted. After irradiation, use a digital display thermometer (configured with a stainless steel probe) to measure the temperature of the solution in the hole, and draw a temperature-time relationship curve (A).

Embodiment 3

[0063] (1) Carboxyl functional modification of gold nanorods: A 20 ml aqueous solution of gold nanorods with a concentration of 1 mmol / L gold element was synthesized using cetyltrimethylammonium bromide (CTAB) as a dispersant and growth director. To the obtained gold nanorod sol solution, 1 mg / ml of HOOC-(CH 2 CH 2 O) 7 -S-S-(CH 2 CH 2 O) 7 -COOH (CAS Number: 873013-93-5) compound was dissolved in 10 ml of water, and then sonicated at 55° C. for 2 hours to obtain a solution of carboxyl-functionalized gold nanorods.

[0064] (2) Surface amino functionalization of mesoporous silicon-based nanoparticles: mesoporous silica nanoparticles (Fe 3 O 4 @mSiO 2 ) 50mg was dispersed in 30ml of ethanol, and the added aminotriethoxysilane was 1 / 10 of the molar amount of mesoporous silicon-based nanoparticles, which was not suitable for Fe 3 O 4 @mSiO 2 Modification was carried out, heated under reflux for 5 hours, the obtained reflux product was centrifuged, and then dispersed in ...

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Abstract

The invention belongs to the field of nanobiological medicaments, and relates to a method for synthesizing a mesoporous silica-based nanocomposite embedded with gold nanorods. Based on the surface carboxyl-functionalization of gold nanorods and the surface amino-functionalization of mesoporous silica-based nanoparticles, the gold nanorods with carboxyl-functionalized surfaces and the mesoporous silica-based nanoparticles with amino-functionalized surfaces are compounded through an amide reaction to obtain the mesoporous silica-based nanocomposite with a uniform outer surface and the steadily embedded gold nanorods, wherein in the compound reaction, the synthesis is directly performed in water, a catalyst is not required to be added, and the acidity or ionic strength are not required to be adjusted. The method is simple and easy, pollution-free, and high in yield. The obtained composite has good dispersibility, biocompatibility and non-toxicity; and the composite possesses high medicament loading rate and medicament sustained-release function of mesoporous silica-based nanometer materials, and a function of the gold nano-rods which converts near infrared light into heat, can realize a therapeutic mode of the synergism of pharmacotherapy and optothermal therapy, and can be widely used in the fields of diagnosis and treatment of diseases, biological sterilization and the like.

Description

technical field [0001] The invention relates to a method for synthesizing a mesoporous silicon-based nanocomposite material inlaid with gold nanorods, belonging to the field of nanometer biomedicine. Background technique [0002] The combination of multiple treatment modes can play a synergistic effect, especially the synergistic treatment mode of hyperthermia and chemotherapy has been widely used in cancer treatment (Iternational Journal of Hyperthermia 2009, Vol.25, No.4, Pages 262-272) . However, the traditional hyperthermia mode cannot precisely control the heating area and power, the traditional chemotherapy drugs are easy to kill normal cells and cause side effects, and in the synergistic treatment, the heating and drugs cannot be guaranteed to act on the tumor at the same time and in the same area. The synergistic treatment effect is significantly reduced and has been limiting the development of this synergistic model. The application and development of nanomaterial...

Claims

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Application Information

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IPC IPC(8): A61K47/02A61K49/08A61N5/06A01N25/08A01P3/00
Inventor 马明陈航榕施剑林陈雨
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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