Aplotaxis carminative sustained-release preparation and preparation method thereof

A slow-release preparation and woody fragrance technology, which is applied in the direction of pharmaceutical formulations, medical preparations containing active ingredients, block delivery, etc., to achieve the effect of rich variety, unique technology and good stability

Active Publication Date: 2011-06-08
山西振东五和堂制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a Muxiang Shunqi sustained-release preparation and

Method used

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  • Aplotaxis carminative sustained-release preparation and preparation method thereof
  • Aplotaxis carminative sustained-release preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Preparation of Muxiang Shunqi Sustained-release Tablets

[0022] Prescription: 20 parts of Muxiang Shunqi prescription drug extract, 20 parts of hypromellose (HPMC), 100 parts of polyvinylpyrrolidone (Kollidon), 10 parts of cross-linked polyvinylpyrrolidone, 2 parts of micronized silica gel, stearic acid Magnesium 2 parts.

[0023] Process: take 20 parts of the extract, 100 parts of Kollidon, and 20 parts of HPMC and pass through a 100-mesh sieve, and set aside; prepare an intermediate by hot-melt extrusion, test the content of the intermediate, and set aside; crush the intermediate, add 10 parts of cross-linked polyvinylpyrrolidone , 2 parts of micropowder silica gel, 2 parts of magnesium stearate, mix evenly, and press into tablets to obtain.

Embodiment 2

[0025] Preparation of Muxiang Shunqi Sustained-release Tablets

[0026] Prescription: 20 parts of Muxiang Shunqi prescription drug extract, 30 parts of hypromellose (HPMC), 80 parts of polyvinylpyrrolidone (Kollidon), 10 parts of cross-linked polyvinylpyrrolidone, 2 parts of micronized silica gel, stearic acid Magnesium 2 parts.

[0027] Process: Take 20 parts of the extract, 80 parts of Kollidon, and 30 parts of HPMC and pass through a 100-mesh sieve, and set aside; prepare an intermediate by hot-melt extrusion, test the content of the intermediate, set aside; crush the intermediate, add 10 parts of cross-linked polyvinylpyrrolidone , 2 parts of micropowder silica gel, 2 parts of magnesium stearate, mix evenly, and press into tablets to obtain.

Embodiment 3

[0029] Preparation of Muxiang Shunqi Sustained-release Capsules

[0030] Prescription: 20 parts of Muxiang Shunqi prescription drug extract, 80 parts of Kollidon, 30 parts of HPMC, 10 parts of cross-linked polyvinylpyrrolidone, 2 parts of micronized silica gel, and 2 parts of magnesium stearate.

[0031] Process: Take 20 parts of the extract, 80 parts of Kollidon, 30 parts of HPMC, and 10 parts of cross-linked polyvinylpyrrolidone, pass through a 100-mesh sieve, and set aside; prepare an intermediate by hot-melt extrusion, detect the content of the intermediate, and set aside; crush the intermediate, Add 2 parts of micropowdered silica gel and 2 parts of magnesium stearate, mix evenly, pack into capsules, and the product is obtained.

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Abstract

The invention relates to an aplotaxis carminative sustained-release preparation and a preparation method thereof. The preparation method comprises the following steps: according to the traditional proportion, preparing aplotaxis, amomum fruit, vinegared rhizoma cyperi, Areca catechu, licorice root, dried orange peel, Mangnolia officinalis, stir-fried fructus aurantii, stir-fried rhizoma atractylodis, stir-fried green tangerine orange peel and ginger into an aplotaxis carminative medicine extract; and preparing 5-50 parts of aplotaxis carminative medicine extract, 10-200 parts of filler, 10-100 parts of sustained-release material, 0-30 parts of disintegrant, 0-10 parts of lubricant, 0-10 parts of flow aid and 10-200 parts of hot-melt extrusion auxiliary material into the aplotaxis carminative sustained-release preparation by using a conventional preparation technique or hot-melt extrusion preparation technique. The aplotaxis carminative sustained-release preparation provided by the invention has the advantages of unique technique, high stability and stable and long-lasting preparation release, and can be continuously and stably released in vivo for 12 hours, so that the active pharmaceutical ingredients can last in vivo for a long time and can be absorbed continuously by human bodies, thereby achieving the goal of long-acting.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and relates to a new dosage form of traditional Chinese medicine Muxiang Shunqi pills and a preparation method thereof, in particular to a Muxiang Shunqi slow-release preparation and a preparation method thereof. Background technique [0002] Functional dyspepsia is a relatively common disease with a slow onset, long course, and often persistent or recurrent attacks. The traditional preparation Muxiang Shunqi Pills is composed of Muxiang, Amomum, Rhizoma Cyperi (made from vinegar), betel nut, licorice, tangerine peel, Magnolia officinalis (made), Citrus aurantium (fried), Atractylodes atractylodes (fried), green peel (fried), Composed of eleven herbs such as dried ginger, it has the effect of promoting qi and removing dampness, strengthening the spleen and harmonizing the stomach, and is clinically used for chest and diaphragm fullness, abdominal distension, vomi...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61K9/22A61K9/52A61K9/16A61P43/00A61P1/14A61P1/08
Inventor 王六贵李明花武勇陈虹
Owner 山西振东五和堂制药有限公司
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