Nano-apatite/collagen compound stent and preparation method and application thereof

Abstract

The invention discloses a nano-apatite / collagen compound stent and a preparation method and an application thereof. The method comprises the steps of firmly distributing nano-apatite in a collage sponge with high porosity, then shaping, freeze-drying and cross-linking for preparation. The nano-apatite / collagen compound stent prepared by the method can be applied as a repair material in orthopaedics and dentistry. The porosity of the nano-apatite / collagen compound stent prepared by the method can be above 98%, the size is distributed in the range of 5-200 mu m, and micropores are mutually communicated; nano-apatite in the nano-apatite / collagen compound stent is distributed in collagen fiber and less prone to shedding; and the original shape can be kept after being immersed in water, and the nano-apatite / collagen compound stent can be restored to the original shape after being extruded.

Description

technical field [0001] The invention belongs to the field of biomaterials, and in particular relates to a nano calcium phosphate / collagen composite scaffold and its preparation method and application. Background technique [0002] Accidents such as daily traffic accidents, safety production accidents, and some orthopedic diseases can cause the loss of human bones. It is estimated that there are about 3 million cases of potential artificial bone and artificial bone joint replacement cases in my country every year. Today, the global potential market for bone graft materials is $650 million. About 4 million patients undergo bone transplantation every year, and 45% of the graft materials used are autologous bone, 40% are allogeneic bone and demineralized bone matrix, and 15% are synthetic materials. [0003] Bone grafts have become the most in-demand grafts after blood transfusions. Currently used bone filling materials mainly include metals, ceramics and synthetic polymers. ...

AI Technical Summary

Problems solved by technology

At present, a small amount of bionic bone products have entered the market, but there are defects such as poor filling, low biocompatibility, and low ability to induce osteoblasts.

[0005] US 5532217 has reported a kind of preparation of collagen fibers by spinning collagen, and the mineralized collagen fibers obtained through mineralization are used for bone repair, but the pore structure of this product is not good, and the collagen fibers obtained by collagen spinning are easily damaged in the body. Rapid degradation; Chinese patent: 200610013009.1 reports a method of extruding mineralized collagen to obtain bone filling materials, but the product has a low porosity, which is not conducive to the proliferation and growth of bone cells; Chinese patent: 200510107942.0 Collagen Mixed with nano-hydroxyapatite and vacuum freeze-dried to obtain bone filling materials, but the hydroxyapatite particles in the product prepared by this method have a weak binding force with collagen and are easy to fall off, resulting in poor biocompatibility

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