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Use of carbon-11 marked N-methyldopamine hydrochloride in preparation of positron medicinal imaging agent

A technology of methyl dopamine and imaging agent, which is applied in the application field of carbon-11 labeling N-methyl dopamine and preparing positron drug imaging agent, which can solve the problems of insufficient research, high cost of electrophilic synthesis, and low yield Low-level problems, to achieve high-specificity effects

Inactive Publication Date: 2011-07-13
王雪梅 +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But due to the synthesis of 6- 18 F-Fluourodopamine requires special equipment, the cost of electrophilic synthesis is high, the synthesis is difficult, and the yield is low, so it has not been widely used
With positron nuclides (such as 11 C. 18 F) Labeling biomolecules for PET / CT imaging can evaluate the innervation and function of the heart has become a future trend, but there are too few related studies

Method used

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  • Use of carbon-11 marked N-methyldopamine hydrochloride in preparation of positron medicinal imaging agent
  • Use of carbon-11 marked N-methyldopamine hydrochloride in preparation of positron medicinal imaging agent
  • Use of carbon-11 marked N-methyldopamine hydrochloride in preparation of positron medicinal imaging agent

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Embodiment 1

[0029] Example 1 Preparation of carbon-11 labeled N-methyl dopamine

[0030] one. 11 C-N-CH 3 -Synthesis of Dopamine

[0031] 1. 11 C- 11 CH 3 Preparation of I

[0032] produced by the cyclotron 11 C-CO 2 It is transported into the chemical reactor and mixed with hydrogen, and reacted at 400°C under the action of Ni catalyst to form 11 CH 4 ; 11 CH 4 React with sublimated iodine at a high temperature of 730°C to generate carbon-11 labeled methyl iodide ( 11 CH 3 I), 11 CH 3 I enters the reaction bottle under the flow rate of 20 mL / min in the helium flow, and 0.4 mL of acetone is placed in the reaction bottle, and placed in the cold hydrazine of minus 20 degrees, finally obtaining 200mCi of carbon-11 methyl iodide acetone solution, wherein The chemical amount of methyl iodide is 2.88ug (when the carbon-11 methyl iodide acetone solution is 300mCi, the chemical amount of methyl iodide is 4.32ug):

[0033] .

[0034] 、 11 CH 3 I react fully with 3 mg (3-6 ...

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Abstract

The invention relates to the field of biological imaging agents, in particular to the use of carbon-11 marked N-methyldopamine hydrochloride in the preparation of a positron medicinal imaging agent. The positron medicinal imaging agent can be used as an organism dynamic imaging agent or a fault imaging agent to display cardiac adrenergic absorption, distribution and metabolic process in a heart disease state and the change law of the sympathetic nerve in a disease state. The 11C-N-CH3-Dopamine imaging is more flexible in estimation of serious degree of acute myocardial ischemia and the reversibility of dysautonomia of patients than N-13-amimmon myocardial blood flow perfusion and has an after-ischemia memory effect and thus provides a strong evidence for the early diagnosis and treatment of heart diseases. The invention can be used for early estimation of myocardial ischemia.

Description

technical field [0001] The invention relates to the field of biological imaging agents, in particular to the application of carbon-11 labeled N-methyl dopamine in the preparation of positron drug imaging agents. Background technique [0002] Normal cardiovascular function depends on innervation of the heart. The adaptability of the heart to the hemodynamic demands of the body under physiological and pathological conditions (especially the rhythm, conduction, and contractility of the heart) is largely regulated by the autonomic nervous system (ANS). In various heart diseases (such as acute and chronic myocardial ischemia, myocardial infarction, arrhythmia, hypertension, diabetes, hypertrophic cardiomyopathy, and familial autonomic dysfunction, etc.), changes in cardiac ANS occur when the heart has obvious structural and Before abnormal function, it cannot be observed by conventional morphological and functional detection methods. Therefore, establishing an evaluation meth...

Claims

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Application Information

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IPC IPC(8): A61K51/04
Inventor 王雪梅何玉林郝林军其其格王相成周伟娜张国建刘彩平王春梅
Owner 王雪梅
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