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Water-soluble photostable silver (I) complex and preparation method and application thereof
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A light-stable, water-soluble technology, applied in botanical equipment and methods, silver-organic compounds, applications, etc., to achieve mild conditions, high yields, and good reproducibility
Active Publication Date: 2011-07-13
溧阳常大技术转移中心有限公司
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On the other hand, in many biomedical applications, light-sensitive, hydrophobic silver complexes are limited, while light-stable, water-soluble silver complexes are popular, but at present, direct Synthesizing silver complexes with these properties is still a big problem. It is difficult to find a suitable ligand to coordinate with silver ions. The complex has good water solubility and high antibacterial activity.
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experiment example 1
[0019] Experimental example 1 Preparation of complexes:
[0020] 1 mmol 3,4,5,6-tetrafluorophthalic acid (0.238 g), 2 mmol silver nitrate (0.339 g), and 40 mL methanol and N,N-dimethylformamide (volume ratio 3:1 ), stirred at room temperature for 0.5-1 hour, filtered, and evaporated at room temperature for 6 days to obtain a colorless needle-like single crystal, which was then washed with 10 mL methanol and 10 mL ether, and dried naturally. The yield was 75%.
[0021] The main infrared absorption peak is 3364 cm-1 , 1641 cm -1 , 1600 cm -1 , 1573 cm -1 , 1487 cm -1 , 1444 cm -1 , 1413 cm -1 , 1335 cm -1 , 1218 cm -1 , 1151 cm -1 , 1117 cm -1 , 1069 cm -1 , 1037 cm -1 , 1095 cm -1 , 947 cm -1 , 853 cm -1 , 753 cm -1 , 697 cm -1 , 616 cm -1 .
experiment example 2
[0022] Experimental example 2 Preparation of complexes:
[0023] 1 mmol 3,4,5,6-tetrafluorophthalic acid (0.238 g), 2.2 mmol silver nitrate (0.373 g) and 40 mL methanol and N,N-dimethylformamide (volume ratio 3:1 ), stirred at room temperature for 0.5-1 hour, filtered, and evaporated at room temperature for 6 days to obtain a colorless needle-like single crystal, which was then washed with 10 mL methanol and 10 mL ether, and dried naturally. The yield is about 72%.
[0024] The main infrared absorption peak is 3364 cm -1 , 1641 cm -1 , 1600 cm -1 , 1573 cm -1 , 1487 cm -1 , 1444 cm -1 , 1413 cm -1 , 1335 cm -1 , 1218 cm -1 , 1151 cm -1 , 1117 cm -1 , 1069 cm -1 , 1037 cm -1 , 1095 cm -1 , 947 cm -1 , 853 cm -1 , 753 cm -1 , 697 cm -1 , 616 cm -1 .
[0025] test one Characterization of complexes:
[0026] (1) Structure determination of complexes
[0027] The crystal structure was determined using a Bruker Apex II CCD diffractometer at 293(2) K with gr...
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Abstract
The invention relates to transition metalcoordination polymer, in particular to a water-soluble photostable silver (I) complex with a bacteriostatic effect and a preparation method thereof. A chemical formula of the complex is [Ag8(L)2(DMF)2]infinite, wherein L is a 3,4,5,6-tetrafluorophthalatedicarboxyl anionic ligand, and DMF is N,N-dimethylformamide. The complex is synthesized in methanol and DMF solution by a solvent volatilization method by taking silver nitrate and 3,4,5,6-tetrafluorophthalic acid as reaction raw materials. The synthesis method is mild in conditions, high in yield and repeatability, and is convenient to operate. A complex crystal sample has high bacteriostatic activity to staphylococcus aureus, Escherichia coli and bacillus subtilis, high water solubility and photostability, is convenient to store and transport, and can be applied to the fields of medical treatment and life science; and the minimal inhibitory concentration is in the range of 0.5 to 2mu g / mL.
Description
technical field [0001] The present invention relates to a transition metalcoordination polymer, in particular to a 3,4,5,6-tetrafluorophthalic acid silver (I) complex, preparation method and application thereof. Staphylococcus aureus, Escherichia coli and Bacillus subtilis have excellent antibacterial activity, the minimum inhibitory concentration range is 0.5-2 μg / mL, and they are water-soluble and photostable. Background technique [0002] The precious metal silver has been an effective antibacterial agent since ancient times, and is regarded as an excellent material that can reduce bacterial adhesion and reproduction. In recent years, silver-containing materials have been widely used in the biomedical industry. In medicine, they can reduce bacterial infections in wound treatment and joint replacement, as well as in prostheses, catheters, artificial blood vessels, dental materials, stainless steel materials, human body The skin, etc. prevent the multiplication of bacteri...
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