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Method for preparing chitosan oligosaccharides through semi-wet method microwave treatment

A technology of microwave treatment and chitosan oligosaccharide, applied in sugar production, sugar production, food science and other directions, can solve the problems of low production efficiency, high energy consumption, many pollutants, etc., and achieve improved production efficiency and high refining efficiency , the effect of less pollution

Active Publication Date: 2012-06-27
YANGZHOU RIXING BIO TECH +1
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  • Summary
  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the degradation of polysaccharides mainly includes chemical and enzymatic degradation, but both chemical and enzymatic degradation are carried out in solvents or solutions, which have the disadvantages of low production efficiency, many pollutants, and high energy consumption.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Add 10kg of chitosan with a fineness of about 80 mesh into the stirring device, add 0.5kg of sodium hydroxide, 1.2kg of hydrogen peroxide solution with a concentration of 30%, and 2kg of water. After stirring for 40 minutes, place the semi-wet chitosan in the microwave In the drying equipment, adjust the microwave power to 3000 watts, process for 30 minutes, dissolve the microwave-treated mixture in water to form a mixed solution with a mass concentration of 8%, adjust the pH value to 6.0 with citric acid or acetic acid, and then dissolve the mixed solution Through the ultrafiltration membrane with a molecular weight cut-off of 2000D, the working pressure is 0.8Mpa, and the filtrate is taken to obtain a mixed solution of chitosan and salt; then the filtrate is passed through a nanofiltration membrane with a molecular weight cut-off of 200-300D, and the working pressure is 1.2 MPa , the oligosaccharide solution intercepted by the nanofiltration membrane was spray-dried, a...

Embodiment 2

[0030] Add 10kg of chitosan with a fineness of about 60 mesh into the stirring device, add 0.6kg of potassium hydroxide, 2kg of hydrogen peroxide solution with a concentration of 25%, and 1.8kg of water, stir for 30 minutes, and place the semi-wet chitosan in the microwave drying equipment , adjust the microwave power to 3400 watts, and treat for 35 minutes, dissolve the microwave-treated mixture in water to form a mixed solution with a mass concentration of 10%, adjust the pH value to 7.0 with hydrochloric acid, and then pass the mixed solution through a filter with a molecular weight cut-off of 3000D Ultrafiltration membrane with working pressure of 0.6 MPa to obtain a mixed solution of chitosan oligosaccharide and salt, and then pass the filtrate through a nanofiltration membrane with a molecular weight cut-off of 200-300D, and a working pressure of 0.8 MPa to obtain the oligosaccharide solution intercepted by the nanofiltration membrane.

[0031] The oligosaccharide solutio...

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Abstract

A method for preparing chitosan oligosaccharides through semi-wet method microwave treatment relates to a production method of chitosan oligosaccharides. The method comprises the following steps: using chitosan gelatine powder as raw material to perform hydration and microwave treatment, dissolving in water, neutralizing, and performing membrane separation, drying and the like to prepare chitosanoligosaccharides. The method does not consume organic solvent, thus the problem of recycling solvent does not exist and the pollution is low; and as the volume of the reaction system is from 1 / 3 to 1 / 5 of that of the solution method, the production efficiency is obivously increased. The method adopts microwave treatment to promote the polysaccharide degradation reaction, thus the heating effect is greatly increased. The radiation thermal effect of microwave and the non-thermal effect of microwave are utilized to prepare the product. Meanwhile, microwave is an efficient and clean energy, thus the speed of the chemical reaction can be greatly increased. The method also adopts the membrane separation mean, thus the refining efficiency is high and the product quality is controllable.

Description

technical field [0001] The invention relates to a production method of chitosan oligosaccharide. Background technique [0002] Chitooligosaccharide is a degradation product of chitosan, generally with a molecular weight of less than 3000 and 2 to 15 sugar chain units. As a new class of physiologically active substances, oligochitosan has been shown by many studies to have the physiological function of inhibiting tumors. Its mechanism of action is mainly that after the combination of acetylglucosamine residues and macrophage surface receptors, macrophages are activated, T cell differentiation is accelerated, and the body’s immunity to tumor cells is improved. Oligochitosan can be used as a therapeutic drug for early tumors. At present, it has become a hot spot of development at home and abroad. Oligochitosan has a significant effect on the resistance to diseases and insect pests and growth promotion of many varieties of fruits, vegetables and grains. Dressing wheat seeds wi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/08C13K13/00
Inventor 孙达锋张卫明张超张和戚善龙
Owner YANGZHOU RIXING BIO TECH
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