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Fe3O4/TiO2 composite nano-particles as well as preparation method and application thereof in magnetic resonance imaging contrast medium

A nanoparticle, fe3o4 technology, applied in nuclear magnetic resonance/magnetic resonance imaging contrast agent, nanotechnology, nanomedicine, etc., to achieve the effect of prolonging the binding time, simple operation and low preparation cost

Active Publication Date: 2011-07-20
NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Moreover, superparamagnetic Fe 3 o 4 Nanoparticle contrast agents generally only have the function of medical imaging diagnosis, and it is difficult to combine with biomolecules or drug molecules to perform therapeutic functions at the same time

Method used

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  • Fe3O4/TiO2 composite nano-particles as well as preparation method and application thereof in magnetic resonance imaging contrast medium
  • Fe3O4/TiO2 composite nano-particles as well as preparation method and application thereof in magnetic resonance imaging contrast medium
  • Fe3O4/TiO2 composite nano-particles as well as preparation method and application thereof in magnetic resonance imaging contrast medium

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] (1) Weigh 3 mmol of citric acid, dissolve it in 350 mL of deionized water, and stir vigorously to ensure that citric acid is fully dissolved, and obtain a citric acid solution for use;

[0035] (2) Weigh 2mmol FeCl respectively 3 ·6H 2 O and 1 mmol FeCl 2 4H 2 O joins in the citric acid solution of above-mentioned preparation, and fully stirs;

[0036] (3) The reaction vessel was placed in an ice bath and stirred for 30 minutes;

[0037] (4) Add 0.1mol / L TiCl dropwise to the reaction vessel 4 Solution 10mL, continue to stir;

[0038] (5) After reacting for 5 hours, put the product into a water bath at 65°C for aging treatment, and the aging time is 22 hours;

[0039] (6) After the product is subjected to dialysis and freeze-drying, powdered Fe 3 o 4 Composite TiO 2 nanoparticle material.

Embodiment 2

[0041] (1) Weigh 6 mmol of citric acid, dissolve it in 350 mL of deionized water, and stir vigorously to ensure that citric acid is fully dissolved, and obtain a citric acid solution for use;

[0042] (2) Weigh 4mmol FeCl respectively 3 ·6H 2 O and 2 mmol FeCl 2 4H 2 O joins in the citric acid solution of above-mentioned preparation, and fully stirs;

[0043] (3) The reaction vessel was placed in an ice bath and stirred for 30 minutes;

[0044] (4) Add 0.6mol / L of TiCl dropwise to the reaction vessel 4 Solution 1mL, continue to stir;

[0045] (5) After reacting for 5 hours, add 50 mL of 0.8 mmol / L CTAB solution to the product, and continue stirring for 30 minutes;

[0046] (6) Put the product into a water bath at 65° C. for aging treatment, and the aging time is 20 hours;

[0047] (7) After the product is subjected to dialysis and freeze-drying, powdered Fe 3 o 4 Composite TiO 2 nanoparticle material.

Embodiment 3

[0049] (1) Weigh 6 mmol of citric acid, dissolve it in 350 mL of deionized water, and stir vigorously to ensure that citric acid is fully dissolved, and obtain a citric acid solution for use;

[0050] (2) Weigh 2mmol FeCl respectively 3 ·6H 2 O and 2 mmol FeCl 2 4H 2 O joins in the citric acid solution of above-mentioned preparation, and fully stirs;

[0051] (3) The reaction vessel was placed in an ice bath and stirred for 30 minutes;

[0052] (4) Add 0.1mol / L TiCl dropwise to the reaction vessel 4 Solution 20mL, continue to stir;

[0053] (5) After reacting for 5 hours, add 50 mL of 0.8 mmol / L SDS solution to the product, and continue stirring for 30 minutes;

[0054] (6) Put the product into a water bath at 65° C. for aging treatment, and the aging time is 20 hours;

[0055] (7) After the product is subjected to dialysis and freeze-drying, powdered Fe 3 o 4 Composite TiO 2 nanoparticle material.

[0056] figure 1 and figure 2 Respectively the Fe prepared in Ex...

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Abstract

The invention relates to Fe3O4 / TiO2 composite nano-particles as well as a preparation method and an application thereof in a magnetic resonance imaging contrast medium. The preparation method of the Fe3O4 / TiO2 composite nano-particles comprises the following steps: dissolving ferric compound and ferrous compound in the aqueous solution of reducing acid; and dropwise adding a titanic salt solutioninto the solution so as to prepare the sol of Fe3O4 / TiO2 composite nano-particles after the reaction. Compared with the prior art, the preparation method of Fe3O4 / TiO2 composite nano-particles provided by the invention is simple to operate and low in preparation cost, and does not need N2 (nitrogen) protection during the reaction; and the product has the advantages of uniform particle size distribution, controllable size, good water solubility and biocompatibility, no toxicity and the like. As the Fe3O4 / TiO2 composite nano-particles prepared by the preparation method provided by the inventionare a composite nano-material with superparamagnetism and optical catalytic activity, the Fe3O4 / TiO2 composite nano-particles can be applied to the magnetic resonance imaging contrast medium.

Description

technical field [0001] The present invention relates to nanoparticle and its preparation method and application, especially relates to Fe 3 o 4 Composite TiO 2 Nanoparticles, methods for their preparation and use in contrast agents for magnetic resonance imaging. Background technique [0002] Magnetic Resonance Imaging (MRI) technology is one of the most important imaging technologies in modern medical clinical diagnosis. Due to the advantages of safe use, high imaging resolution, less artifacts, and rich information provided, MRI is currently almost used Examination of any part of the human body. In medical diagnosis, the sensitivity of MRI has a very important relationship with the contrast agent material used. Materials that can be used as MRI contrast agents include nanomaterials such as superparamagnetic oxide nanoparticles and gadolinium-containing coordination compounds. Compared with gadolinium complexes, which are often used as T1 contrast agents, superparamagn...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/06A61K47/02A61K47/48
CPCA61K49/1818B82Y5/00
Inventor 吴爱国曾乐勇
Owner NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI
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