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Preparation method of gynura japonica alkaloid

A technology of alkaloids and notoginseng, which is applied in the field of preparation of chrysanthemum notoginseng alkaloids, can solve the problems of short cycle, high cost, low yield, etc., and achieve the effects of adsorption and purification of macroporous resin, cost saving and high efficiency

Inactive Publication Date: 2011-08-03
NANJING ZELANG AGRI DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Such as the Chinese patent "Supercritical Carbon Dioxide Extraction Method for Radix Notoginseng Alkaloids", the disclosed method is to use supercritical carbon dioxide to extract the alkaloid components of Radix Notoginseng, this method has high extraction rate and short cycle, but the cost is relatively high. High, high requirements for technology and equipment
For example, in Jiang Juanjuan et al.'s research on the chemical components of the underground part of Jusanqi, the monomer components were obtained by repeated extraction with organic solvents and repeated chromatography on silica gel columns. Low

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Take 1 kg of chrysanthemum notoginseng medicinal material, crush it, add 2 times the amount of 5% ammonia water to soak overnight, use 80% ethanol solution as the solvent for ultrasonic extraction, and the ultrasonic frequency is 25KHz to obtain the extract, concentrate to extract, and dissolve with 5% hydrochloric acid solution , filter, add 5% ammonia solution to the filtrate until no precipitation occurs, filter the precipitate, dissolve it with a small amount of ethanol, add an appropriate amount of AB-8 macroporous resin, evaporate the solvent, pack the column, and first elute with 5L of 15% ethanol solution , the eluent was discarded, and then eluted with 80% ethanol solution, and the eluent was concentrated and dried to obtain 18.0 g of alkaloids of notoginseng with a content of 78.7%.

Embodiment 2

[0018] Take 1 kg of chrysanthemum notoginseng medicinal material, crush it, add 4 times the amount of 3% ammonia water to soak overnight, use 85% ethanol solution as the solvent for ultrasonic extraction, and the ultrasonic frequency is 20KHz to obtain the extract, concentrate to extract, and dissolve with 5% hydrochloric acid solution , filter, add 5% ammonia solution to the filtrate until no precipitation occurs, filter the precipitate, dissolve it with a small amount of ethanol, add an appropriate amount of AB-8 macroporous resin, evaporate the solvent, pack the column, and first elute with 4L of 20% ethanol solution , the eluent was discarded, and then eluted with 80% ethanol solution, and the eluent was concentrated and dried to obtain 15.9 g of alkaloids of notoginseng with a content of 77.2%.

Embodiment 3

[0020] Take 1 kg of chrysanthemum notoginseng medicinal material, crush it, add 3 times the amount of 3% ammonia water to soak overnight, use 95% ethanol solution as the solvent for ultrasonic extraction, and the ultrasonic frequency is 35KHz to obtain the extract, concentrate to extract, and dissolve with 5% sulfuric acid solution , filter, add 5% ammonia solution to the filtrate until no precipitation occurs, filter the precipitate, dissolve it with a small amount of ethanol, add an appropriate amount of S-8 macroporous resin, evaporate the solvent, pack the column, and first elute with 5L of 10% ethanol solution , the eluent was discarded, and then eluted with 80% ethanol solution, and the eluent was concentrated and dried to obtain 15.5 g of alkaloids of notoginseng with a content of 65.8%.

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Abstract

The invention relates to the preparation method of gynura japonica alkaloid, which comprises the following steps of: 1) crushing gynura japonica medicine materials, adding aqueous ammonia to soak the gynura japonica medicine materials, and adopting 80-95% of ethanol solution as a solution medium to extract the gynura japonica medicine materials through ultrasonic wave to obtain extract; 2) concentrating the extract to obtain extractum, dissolving the extractum through acid water, filtering the solution, adding an alkali liquid into the filtrate until precipitate cannot be produced any more, and filtering the precipitate; and 3) purifying the obtained precipitate through a macroporous resin column to obtain the gynura japonica alkaloid. The process in the invention is simple and easy to operate, lead to less pollution on the environment, and is suitable for industrialized production.

Description

Technical field: [0001] The invention relates to a preparation method of chrysanthemum notoginseng alkaloids, in particular to a method for adsorbing and purifying chrysanthemum notoginseng alkaloids with macroporous resins. Background technique: [0002] Chrysanthemum notoginseng dicotyledonous plant medicine Compositae plant notoginseng root, also known as soil notoginseng, gold not changing, purple notoginseng, chrysanthemum leaf notoginseng, etc., has the effect of dispelling blood stasis, relieving pain, nourishing qi and absorbing blood, and is used for the treatment of falling Injuries, fractures, traumatic bleeding, vomiting blood, postpartum abdominal pain and other diseases. Chrysanthemum notoginseng is mainly distributed in Sichuan, Yunnan, Guangdong, Guangxi, Jiangsu, Jiangxi, Hunan, Guizhou and other places. [0003] Chrysanthemum notoginseng mainly contains alkaloids and flavonoids, and its main active ingredient is alkaloids. Existing extraction methods of c...

Claims

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Application Information

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IPC IPC(8): A61K36/28A61P7/04A61P17/02A61P19/08A61P29/00
Inventor 苏刘花
Owner NANJING ZELANG AGRI DEV
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