Preparation method of D-Glucosamine Hydrochloride

Abstract

The invention discloses a preparation method of D-Glucosamine Hydrochloride, wherein citric acid waste residue, gained after production of the citric acid with a fermentation method, are used as raw material, and the D-Glucosamine Hydrochloride is prepared by the steps of hydrolysis, pumping filtration, concentration, etc. According to the invention, the citric acid waste residue is recycled, so that the waste residue pollution of the environment is mitigated; and the D-Glucosamine Hydrochloride produced with the citric acid waste residue as raw material is a D-Glucosamine Hydrochloride of vegetarian diet which has no fishlike smell, is not polluted by heavy metal, is safe and environmentally friendly, has a product purity up to 98-102% and accords with the quality standard of United States Pharmacopeia USP 32 edition. At the same time, because raw material resource is abundant, production resource has no restriction and production cost is low; further, cost in treatment of the environmental pollution is saved and relatively high circular economic gain is achieved; and more preferably, under the circumstance that technology prejudice in the technology field is overcome and simultaneously the product purity is guaranteed, output and production efficiency of the product are increased and time of the hydrolysis reaction is shortened.

Description

technical field [0001] The invention relates to the field of glucosamine hydrochloride, in particular to a method for preparing glucosamine hydrochloride from citric acid waste residue. Background technique [0002] Citric acid is a widely used organic acid. It can be used as a sour agent, thickener, and cleaning agent. It is widely used in food, beverage, pharmaceutical, chemical, detergent and other industries. Stimulated by exports, my country's domestic citric acid production increased from 380,000 tons in 2001 to 700,000 tons in 2005, and about 800,000 tons in 2006, with an average annual increase of 12.5%. 70% of the world. At present, in the process of producing citric acid by fermentation method in most enterprises, a large amount of citric acid waste residue is not comprehensively utilized, and is directly discharged. [0003] Glucosamine Hydrochloride, English D~Glucosamine Hydrochloride, molecular formula C 6 h 13 NO 5 ·HCl, white crystal, odorless, slightly s...

AI Technical Summary

Problems solved by technology

[0005] First, glucosamine hydrochloride extracted from the shell of aquatic products is not suitable for many patients with allergic reactions to aquatic products;

[0006] Second, the purification process is complicated, and the product has a fishy smell and is unstable;

[0007] Third, affected by marine environmental pollution, glucosamine hydrochloride extracted from shrimp and crab shells is inevitably polluted by heavy metals

[0008] In order to solve the defects of the above-mentioned production method, before the present invention, some records related to the use of citric acid waste residue for the preparation of glucosamine hydrochloride invention patents are disclosed, such as patents such as CN200810088877.5 and CN200810238484.8, but these The inventors of the patent all have a misunderstanding in their understanding. They all believe that the volume concentration of hydrochloric acid and the hydrolysis reaction temperature should not be too high at the same time, especially the hydrolysis reaction temperature should not exceed 90°C, otherwise it will easily cause carbonization of citric acid waste residue, resulting in a loss of production low

In addition, when the reaction is carried out at a temperature lower than 90°C, the reaction time will be greatly prolonged. Generally, each reaction time needs to be more than 10 hours to fully react, but this greatly reduces the production capacity. efficiency