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Streptomyces hawaii and application thereof

A technology of Streptomyces hawaii and tylosin, applied in the direction of bacteria, microorganisms, biochemical equipment and methods, etc.

Active Publication Date: 2011-08-31
湖北回盛生物科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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And the fermentation time is 5 days, which is 2 days shorter than the existing production process

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  • Streptomyces hawaii and application thereof
  • Streptomyces hawaii and application thereof
  • Streptomyces hawaii and application thereof

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[0015] The present invention will be further described below in conjunction with the accompanying drawings; unless otherwise specified, the methods involved in the present invention are conventional methods; the reagents and biological materials, if specified, can be obtained from commercial sources.

[0016] Bacterial strain of the present invention ( Streptomyces hawaiiensis 0915 ) at 28°C grew well on Gao’s No. 1 agar medium and malt powder medium. After 5 days of culture, a single colony began to appear clearly visible. The hyphae are flesh-colored to yellow-brown, and the single colony is shiny, round, with neat edges, gathered around the center, and the center of the colony is raised upwards. The colonies that grow together are wrinkled. Both the aerial hyphae and the hyphae in the base are yellow, and no soluble pigments are produced (see figure 1 , where the left picture is the front view, and the right picture is the rear view). There was no growth under 50°C cul...

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Abstract

The invention relates to Streptomyces hawaii. The microorganism can be used for producing acetylisovaleryl tylosin through fermentation, and the fermentation time is short. Tylosin is supplemented by using a continuous flow, subtract inhibition is reduced, a forward reaction is promoted, and thus, the efficacy of AIV (Avian Influenza Virus) is improved. The fermentation time is 5 days and is shortened by 2 days as compared with the traditional production process. The preservation name of Streptomyces hawaii provided by the invention is Streptomyces hawaiiensis 0915, the preservation unit is the China Center for Type Culture Collection, the preservation date is October 16th, 2010, and the preservation number is CCTCC NO: M2010261. In the fermentation process, the fermentation period is 5 days no matter for flask shaking fermentation or for various tank fermentations and is shortened by 2 days as compared with the fermentation time of reported Streptomyces thermotolerans E1 strains. The efficacy of Streptomyces hawaiiensis after fermentation 0915 CCTCC NO: M2010261 is 18.6 mg / ml, and the transformation efficiency is as high as 90% and is obviously higher than that of the reported Streptomyces thermotolerans.

Description

technical field [0001] The invention relates to a hawaiian streptomyces and its application, belonging to the field of biotechnology. Background technique [0002] (Tylosin) is a special antibiotic for livestock and poultry. It was first isolated from the soil of Thailand by American scholar Hamill et al. in 1961. The producing bacteria include Streptomyces freundii ( Streptomyces fradiae , NRR2702, 2703) , Streptomyces crackus ( Streptomyces rimosns ) and Streptomyces hygroscopicus ( Streptomyces hygroscopicus ). Features of tylosin: 1. It has significant anti-mycoplasma (mycoplasma) effect, and has a strong inhibitory effect on mycoplasma pleuropneumoniae and other mycoplasma, and is the drug of choice for mycoplasma infectious diseases in livestock and poultry. 2. It has a wide antibacterial spectrum, mainly has a strong inhibitory effect on a variety of Gram-positive bacteria, and also has inhibitory effects on some Gram-negative bacteria, Campylobacter (belonging t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N1/20C12P17/08C12R1/465
Inventor 张卫元郝勃毛涛
Owner 湖北回盛生物科技有限公司
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