Enzymatic synthesis method of S-alpha-D-glucoside-L-cysteine

A technology of cysteine ​​and glucoside, applied in the field of enzymatic synthesis of S-α-D-glucoside-L-cysteine, to achieve the effect of improving substrate utilization
CN102174622BInactive Publication Date: 2012-12-19NANJING TECH UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
NANJING TECH UNIV
Publication Date
2012-12-19
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses an enzymatic synthesis method of S-alpha-D-glucoside-L-cysteine. Aqueous solution containing sucrose and L-cysteine is used as a substrate, sucrose phosphorylase is added, and the S-alpha-D-glucoside-L-cysteine is prepared by transglucose-based reaction of the sucrose phosphorylase. Compared with a chemical synthesis method, group protection and removal are not needed and the steps are simple in the method; the reaction raw materials are simple, easily obtained and environment-friendly; and the sucrose phosphorylase is obtained by simple fermentation of leuconostosm esenteroides, so the cost is low.
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Description

technical field

[0001] The invention belongs to the field of biochemical industry and relates to an enzymatic synthesis method of S-α-D-glucoside-L-cysteine. Background technique

[0002] Oligosaccharide complexes play an important role in the biological activities of various organs of living tissues, such as: cell recognition, information transmission between cells and cell adhesion process. The carbohydrate group attached to the polypeptide can increase its water solubility, and can also be used as a targeted drug to target biologically active compounds. The glucosinolate formed by connecting the cysteine-SH group with a glucose group has high chemical stability and has great application in the synthesis of polypeptide glucosinolate derivatives. The application of glucosinolates in anticancer drugs has been further expanded in recent years, leading to the great application of cysteine ​​glucosinolates in the synthesis of anticancer drugs and targeted drugs in the process ...

Claims

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