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Application of taurochenodeoxycholic acid to protection of gastrointestinal tract function

A technology of taurine chenodeoxycholic acid and digestive tract, which is applied to the digestive system, medical preparations containing active ingredients, organic active ingredients, etc., can solve problems such as difficulty in meeting modern technologies

Inactive Publication Date: 2011-09-14
SHANDONG AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the research on how to use natural substances to directly act on the digestive tract to protect the function of the digestive tract is still in a relatively primitive stage, and it is difficult to meet the requirements of modern technology

Method used

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  • Application of taurochenodeoxycholic acid to protection of gastrointestinal tract function
  • Application of taurochenodeoxycholic acid to protection of gastrointestinal tract function
  • Application of taurochenodeoxycholic acid to protection of gastrointestinal tract function

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Experimental program
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Effect test

Embodiment 1

[0017] During the experiment, they were divided into normal group, model group and drug administration group, each with 10 mice. The normal group was only fed with distilled water; the model group was injected intraperitoneally with 80 mg / kg dexamethasone for 7 consecutive days to prepare the mouse model of gastrointestinal injury caused by glucocorticoids; the administration group was prepared in the model After completion of the administration, the dose of TCDCA in the administration group was 0.1 g / kg, and the route of administration was intragastric administration, once a day, for 7 consecutive days. HE staining of paraffin sections was used to evaluate the influence of TCDCA on the pathological changes of the digestive tract, the results are shown in the attached figure 1 And attached image 3 shown. In the model group, the small intestinal submucosa was loose and edema, with inflammatory cell infiltration, degeneration and necrosis of the small intestinal villi, and th...

Embodiment 2

[0019] During the experiment, they were divided into normal group, model group and drug administration group, each with 10 mice. The normal group was only fed with distilled water; the model group was injected intraperitoneally with 80 mg / kg dexamethasone for 7 consecutive days to prepare the mouse model of gastrointestinal injury caused by glucocorticoids; the administration group was prepared in the model After completion of the administration, the dose of TCDCA in the administration group was 0.1 g / kg, and the route of administration was intragastric administration, once a day, for 7 consecutive days. EDU was injected intraperitoneally into mice in each group, and the effect of TCDCA on the proliferation of digestive tract cells was detected by EdU DNA in vivo Kit. Observe under a fluorescence microscope at 200 times, excite and irradiate with ultraviolet light and green light respectively and take pictures. Three consecutive fields of view of small intestine tissue were s...

Embodiment 3

[0024] During the experiment, they were divided into normal group, model group and drug administration group, each with 10 mice. The normal group was only fed with distilled water; the model group was injected intraperitoneally with 80 mg / kg dexamethasone for 7 consecutive days to prepare the mouse model of gastrointestinal injury caused by glucocorticoids; the administration group was prepared in the model After completion of the administration, the dose of TCDCA in the administration group was 0.1 g / kg, and the route of administration was intragastric administration, once a day, for 7 consecutive days. The content of SlgA in the small intestine homogenate was detected by radioimmunoassay, and the results are shown in Table 2. Compared with the normal group, the medium-dose group can significantly promote the secretion of intestinal SIgA; compared with the model group, the low-, medium-, and high-dose groups can significantly or extremely significantly enhance the secretion o...

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Abstract

The invention relates to new application of taurochenodeoxycholic acid, in particular to new application of taurochenodeoxycholic acid to protection of a gastrointestinal tract function. The inventor researches the taurochenodeoxycholic acid to find that the taurochenodeoxycholic acid can enhance the immune function of mucosa, can promote proliferation of enteral stem cells and can alleviate alimentary tract tissue structure injury, so that the taurochenodeoxycholic acid can be applied to protecting the gastrointestinal tract function, can be administrated directly, and can also be prepared into various formulations of medicaments for enhancing mucosal immunization and preventing and treating gastrointestinal diseases.

Description

technical field [0001] The invention relates to a new application of taurochenodeoxycholic acid, in particular to a new application of taurochenodeoxycholic acid in protecting the function of the digestive tract. Background technique [0002] Taurochenodeoxycholic Acid (TCDCA) is a conjugated bile acid mainly present in the bile of chickens, ducks, geese, cattle, sheep, snakes and other animals. Its chemical name is 3α, 7α-dihydroxy-5β-24-cholanoyl-N-taurine, and its structural formula is as follows: [0003] [0004] It is an odorless, white powder, extremely bitter acidic compound formed by combining taurine (Tau) and chenodeoxycholic acid (CDCA). The molecular formula is C 23 (OH) 2 h 37 CONHCH 2 CH 2 SO 3 H, the relative molecular mass is 499.69. As a main component of bile, TCDCA has the characteristics of wide range of drug sources, safety and efficacy. Current studies have found that TCDCA has anti-inflammatory (Li Peifeng, Cao Jinshan, Guan Hong, etc. Jour...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/575A61P1/00A61P37/04
Inventor 石有斐李金莲王丛丛李培锋
Owner SHANDONG AGRICULTURAL UNIVERSITY
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