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Application of Juncus effuses L. extract in preparing anti-tumor or angiogenesis-inhibiting medicament, health food or cosmetic

An angiogenesis and extract technology, applied in the direction of antineoplastic drugs, cosmetics, cosmetic preparations, etc., to achieve the effect of inhibiting tumor and tumor angiogenesis

Inactive Publication Date: 2011-09-21
苏州中药研究所有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] According to the investigation of existing technology, the extract of Juncus effuses L., especially the alcohol extract of Juncus effuses L., the effect of the part of petroleum ether and the part of ethyl acetate on the tumor and tumor angiogenesis and its effect on the preparation of anti-tumor or inhibiting tumor angiogenesis The application in medicine, health food or cosmetics has not been reported in domestic and foreign literature

Method used

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  • Application of Juncus effuses L. extract in preparing anti-tumor or angiogenesis-inhibiting medicament, health food or cosmetic
  • Application of Juncus effuses L. extract in preparing anti-tumor or angiogenesis-inhibiting medicament, health food or cosmetic
  • Application of Juncus effuses L. extract in preparing anti-tumor or angiogenesis-inhibiting medicament, health food or cosmetic

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Preparation of rushes ethanol extract and water extract: dry rushes material, crushed, 5-10 times the amount of 95% ethanol or water-cooled soaking extraction twice, each time 24h, combined extracts, filtered, concentrated under reduced pressure to obtain thick soaking paste, put it in an oven and dry it at 65°C to get it.

Embodiment 2

[0043] Preparation of rushes petroleum ether and ethyl acetate parts: dry rushes material, crushed, 5-10 times the amount of 95% ethanol for cold extraction twice, each time for 24 hours, combined extracts, filtered, concentrated under reduced pressure to obtain a thick extract , add water to suspend, sequentially extract with petroleum ether (60-90°C) and ethyl acetate. The petroleum ether layer and the ethyl acetate layer extract are recovered respectively to obtain the petroleum ether extract and the ethyl acetate extract. The yields are about 1% and 5%, respectively.

Embodiment 3

[0044] Example 3: The in vitro experiment of the ethanol extract of Rush radix inhibiting the proliferation of tumor cells

[0045] Experimental Materials

[0046] 1 tumor cell line

[0047] Human Burkitt's lymphoma cells Namalva and Raji, pre-tumor stem cells 2C4G2, PMKO102-3# and p3B11, human T lymphocytic leukemia cell Jurkat, human T lymphocyte line H9, human breast cancer cell line MCF-7, human leukemia cell line UC -CUC, NB4 and HL-60, human osteosarcoma cell lines U-2OS and SW1353, human melanoma cell line C8161, human lung cancer cells (lymph node metastasis) NCI-H292, human gastric cancer cell line HGC-27, human liver cancer cell line HepG2 and human colon cancer cell line SW480 were cryopreserved in our laboratory.

[0048] Cell culture medium RPMI 1640 and DMEM (high sugar) are products of Hyclone Company. Alamarblue reagent is the product of INVITROGEN company.

[0049] 2 test drug

[0050] The ethanol extract of the rushes (prepared according to the method in...

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Abstract

The invention discloses application of Juncus effuses L. extract in preparing an anti-tumor or angiogenesis-inhibiting medicament. The invention discloses that the Juncus effuses L. extract has activities of inhibiting tumor and tumor angiogenesis for the first time, and the Juncus effuses L. extract can be used for treating or preventing diseases related to tumor and tumor angiogenesis, and also can be used in treatment for chemotherapy and / or adjuvant chemotherapy of tumor. The invention takes angiogenesis as the target spot for treating diseases, studies and explains the pharmaceutical curative effects and mechanism of the Juncus effuses L. extract, and provides a scientific basis and important information for the development of new use of the Juncus effuses L. extract and discovery of new target spots of drug action. The Juncus effuses L. extract can be applied to medicaments, health products and / or cosmetics and the like.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine. It specifically relates to the application of a rush extract in the preparation of anti-tumor or angiogenesis-inhibiting drugs, health food or cosmetics. Background technique [0002] Tumor is a disease that seriously threatens human life and health. Statistics from the Ministry of Health show that the number of malignant tumor patients in China has reached 115-1.27‰, and the number of deaths due to malignant tumors ranks second among all causes of death. Although great progress has been made in the treatment of malignant tumors in the past half century, there is still a lack of ideal therapeutic drugs to meet clinical needs, and malignant tumors are still regarded as refractory diseases. Finding safe and effective anti-tumor drugs is still a hot and difficult point in the medical circles of various countries. [0003] Tumor growth and metastasis rely on new blood vessels t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/88A61K8/97A23L1/29A61Q19/00A61P35/00A61P9/10A61P17/02A61P17/06A61P17/08A61P17/10A61P19/02A61P27/02A61P27/06A61P29/00A23L33/00
Inventor 顾振纶周泉生蒋小岗曹志飞朱峰妍郭次仪
Owner 苏州中药研究所有限公司
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