Evening primrose oil microcapsule and pulverization method

A technology of microcapsules and powdering, applied in microcapsules, capsule delivery, pharmaceutical formulations, etc., can solve the problems of high energy consumption of evening primrose oil microcapsules, high requirements on wall material specifications, poor capsule shell compactness, etc. Antioxidant performance, good dispersibility, good film-forming effect

Inactive Publication Date: 2011-10-05
HEILONGJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation of evening primrose oil microcapsules by this method requires high energy consumption, high wall material specifications, complicated opera

Method used

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  • Evening primrose oil microcapsule and pulverization method
  • Evening primrose oil microcapsule and pulverization method
  • Evening primrose oil microcapsule and pulverization method

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0026] Example 1:

[0027] A powdering method of evening primrose oil microcapsules. The method adopts a solvent-non-solvent method to coat the evening primrose oil into microcapsules. The solvent-non-solvent method includes the following steps:

[0028] 1) Mix acrylic resin No. Ⅱ or acrylic resin No. Ⅲ or acrylic resin No. Ⅱ and acrylic resin No. Ⅲ mixture in a certain proportion and dissolve it with ethanol as the wall material solution.

[0029] ) Add evening primrose oil and polyoxyethylene hydrogenated castor oil RH40, high shear emulsification and dispersion to form a stable O / W emulsion.

[0030] ) While stirring, add dropwise sodium lauryl sulfate solution to the core material, wall material and the core material. As the water content in the system continues to increase, the concentration of ethanol decreases, resulting in a decrease in the solubility of the wall material. Evening primrose oil is coated to form microcapsules.

[0031] ) After filtration, wash twice with 0.2% so...

Example Embodiment

[0032] Example 2:

[0033] An evening primrose oil microcapsule, its composition includes: evening primrose oil core material, acrylic resin II or acrylic resin III or acrylic resin II and acrylic resin III, polyoxyethylene hydrogenated castor oil RH40, characterized in that: The weight parts of the evening primrose oil core material is 1, the weight parts of the acrylic resin II or the acrylic resin III or the acrylic resin II and the acrylic resin III are 0.6-8.5; the polyoxyethylene hydrogenated castor oil The weight parts of RH40 is 0.05~0.5. Attached image 3 Middle (?) is evening primrose oil; (▲) is evening primrose oil microcapsules.

Example Embodiment

[0034] Example 3:

[0035] In the evening primrose oil microcapsules and powdering method described in the above examples, weigh 8 g of acrylic resin No. II and acrylic resin No. III (1:1), dissolve it with 95% ethanol, and add 2 g of evening primrose oil. Polyoxyethylene hydrogenated castor oil RH40 0.2 g, homogenized and emulsified at 10000 rpm for 2 min, add 0.2% sodium lauryl sulfate solution dropwise with a 50 ml acid burette, while stirring at 1000 rpm until a large amount of microcapsule solids are deposited in the solution , After filtering, washing with 0.2% sodium lauryl sulfate solution twice, filtering and drying under reduced pressure to obtain evening primrose oil microcapsule powder. The finally obtained evening primrose oil microcapsules were white powder, with good fluidity and good oxidation resistance. The average particle size of the microcapsules was 7.66 μm measured by a laser particle size analyzer, and the encapsulation efficiency was 95.7%.

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Abstract

The invention relates to an evening primrose oil microcapsule and a pulverization method. Evening primrose oil is difficult to dissolve in water and ethanol, is easy to be oxidized by oxygen and has a special grease taste; currently, crude evening primrose oil and evening primrose oil soft microcapsule are mainly products in a market, thereby greatly limiting the application range of the evening primrose oil as a functional health care product and a food additive. The evening primrose oil microcapsule is characterized by comprising the following components in parts by weight: 1 part of evening primrose oil core material, 0.6-8.5 parts of acrylic resin II or acrylic resin III or acrylic resin II and acrylic resin III and 0.05-0.5 part of polyoxyethylene hydrogenated castor oil RH40. The evening primrose oil microcapsule is applied to the field of medicaments.

Description

Technical field: [0001] The invention relates to a method for use in the field of medicine; in particular, it relates to a microcapsule of evening primrose oil and a powdering method. Background technique: [0002] Evening primrose is a wild plant in Northeast my country, with abundant reserves and wide sources. Its seed oil is called evening primrose oil, which has various physiological activities. Evening primrose oil contains a variety of unsaturated fatty acids that are necessary for human growth and cannot be synthesized in the body, such as linolenic acid, linoleic acid, arachidonic acid, and γ-linolenic acid, which is rare in the plant kingdom. The human body can also convert various fatty acids to meet the physiological needs of the human body, but for a few specific fatty acids such as γ-linolenic acid, linoleic acid and linolenic acid, the human body cannot synthesize them by itself and must be obtained through food intake . Modern pharmacological studies have pr...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61K9/50A61K47/32A61K47/34A61P3/04A61P3/06A61P7/02A61P9/10A61P29/00A61P39/06
Inventor 李强张士伟赵学玲龚显峰刘丽娟
Owner HEILONGJIANG UNIV
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