Preparation method for anti-infectious nano collagen/ calcium phosphate bone repair material
A calcium phosphate bone and repair material technology, applied in medical science, prosthesis, etc., to achieve good strength and biocompatibility, promote adhesion and stretching, and excellent biocompatibility
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Embodiment 1
[0025] The materials used are type I collagen gel (concentration: solid content 1%, the collagen contained is purified cowhide collagen), analytically pure CaCl 2 ·6H 2 O. Analytical pure Na 2 HPO 4 , Analytical pure 1,4-dioxane, L-polylactic acid (PLLA) Molecular weight: 100,000.
[0026] (1) Dissolve 20g of collagen gel in 0.5M acetic acid solution to prepare 7.0×10 -4 g / ml collagen solution, slowly add CaCl dropwise to the collagen solution 2 solution, the dropping amount is 0.09 mol of calcium ion per gram of collagen;
[0027] (2) Add Na slowly while stirring in the solution made in step (1). 2 HPO 4 Aqueous solution, added Na 2 HPO 4 with added CaCl 2 The molar ratio is 2:1;
[0028] (3) Slowly add NaOH solution dropwise while stirring in the solution made in step (2) until the pH is 6-8, and the pH value is measured with test paper or a pH meter, and precipitation begins to occur when the pH is 5-6, and the pH value When it was 7, a white suspension appeared;...
Embodiment 2
[0036] The materials used are type I collagen gel (concentration: solid content 1%, the collagen contained is purified cowhide collagen), analytically pure CaCl 2 ·6H 2 O. Analytical pure Na 2 HPO 4 , Analytical pure 1,4-dioxane, L-polylactic acid (PLLA) Molecular weight: 100,000.
[0037] (1) Dissolve 20g of collagen gel in 0.1M hydrochloric acid solution to prepare 5.0×10 -5 g / ml collagen solution, slowly add CaCl dropwise to the collagen solution 2 solution, the dropping amount is 0.01mol of calcium ion per gram of collagen;
[0038] (2) Add Na slowly while stirring in the solution made in step (1). 2 HPO 4 Aqueous solution, added Na 2 HPO 4 with added CaCl 2 The molar ratio is 2:1;
[0039] (3) Slowly add NaOH solution dropwise while stirring in the solution made in step (2) until the pH is 6-8, and the pH value is measured with test paper or a pH meter, and precipitation begins to occur when the pH is 5-6, and the pH value When it was 7, a white suspension appe...
Embodiment 3
[0047] The materials used are type I collagen gel (concentration: solid content 1%, the collagen contained is purified cowhide collagen), analytically pure CaCl 2 ·6H 2 O. Analytical pure Na 2 HPO 4 , Analytical pure 1,4-dioxane, L-polylactic acid (PLLA) Molecular weight: 100,000.
[0048] (1) Dissolve 20g of collagen gel in 0.2M nitric acid solution to prepare 5.0×10 -3 g / ml collagen solution, slowly add CaCl dropwise to the collagen solution 2 solution, the dropping amount is 0.16 mol of calcium ion per gram of collagen;
[0049] (2) Add Na slowly while stirring in the solution made in step (1). 2 HPO 4 Aqueous solution, added Na 2 HPO 4 with added CaCl 2 The molar ratio is 2:1;
[0050] (3) Slowly add NaOH solution dropwise while stirring in the solution made in step (2) until the pH is 6-8, and the pH value is measured with test paper or a pH meter, and precipitation begins to occur when the pH is 5-6, and the pH value When it was 7, a white suspension appeared;...
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