Guidewire

A wire and coil technology that is applied to the field of wires with a lubricated surface, which can solve the problems of reduced wire operability, blood vessel perforation, and cracks, and achieve the effects of ensuring softness, ensuring slidability, and improving slidability

Inactive Publication Date: 2011-10-05
ASAHI INTECC CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, as described in Patent Document 1 or Patent Document 2, if only high biocompatibility polymers or hydrophilic polymers are crosslinked, the formed coating will become hard as a whole, and the properties of the wire will be lost. Softness, which can cause perforation of blood vessels etc. when the guide wire is manipulated
In addition, when the lead wire whose coating is hardened as a whole is bent, cracks (cracks) are formed in the coating, and the coating peels off due to the cracks.
In addition, since the cross-linking of the hydrophilic coating is to use the hydrophilic functional group for the cross-linking reaction, if only the same cross-linking is performed on the hydrophilic coating, the surface of the hydrophilic coating will have hydrophilic properties. The functional groups decrease, which reduces the slipperiness, thereby reducing the operability of the wire

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0107] First, 2 g of polyvinyl alcohol and 1 g of water-soluble carbodiimide were dissolved in 106 ml of dimethylformamide as a solvent to prepare a hydrophilic coating solution (solution A).

[0108] Next, put figure 1 In the shown wire, the leading end portion made of Sn—Ag and the coil member made of SUS316 (SUS316, stainless steel) were immersed in the solution A.

[0109] Next, drying was performed at 120° C. for 2 hours in a drying oven to remove dimethylformamide as a solvent, and a crosslinking reaction by water-soluble carbodiimide proceeded.

[0110] Thereby, a conductive wire covered with a hydrophilic paint having a thickness of 1 μm whose degree of crosslinking decreases from the coil member side toward the surface side of the hydrophilic paint is obtained, and figure 1 wires described in.

Embodiment 2

[0112] First, from 2-methyl-2-acrylic acid-2-(phosphonooxy) ethyl ester (Axidhoshokishimetakrilet) having a phosphoric acid group in the monomer unit (trade name: Hosuma-Muni Chemical Co., Ltd. 2 g of the polymer constituted by production) was dissolved in 100 ml of water as a solvent to prepare a solution B having a tie layer component.

[0113] Next, 0.5 g of sodium hyaluronate and 1 g of water-soluble carbodiimide were dissolved in 100 ml of water as a solvent to prepare a solution of a hydrophilic coating material (solution C).

[0114] Next, using a vacuum ultraviolet ray irradiation device (manufactured by ゥゥオオデォテディコラングタル), the leading end portion of the same lead wire and the coil member as in Example 1 were irradiated with UV at 172 nm for 5 minutes in air.

[0115] Next, the UV-irradiated portion was immersed in solution B, and then dried in a drying oven at 120° C. for 2 hours to remove the solvent and form a connection layer on the surface of the coil member and the...

Embodiment 3

[0118] First, a solution B composed of the same components as in Example 2 was prepared.

[0119] Next, 2 g of polyvinyl alcohol and 1 g of water-soluble carbodiimide were dissolved in 100 ml of water as a solvent to prepare solution D as a hydrophilic coating material for the lower layer.

[0120] Next, 0.5 g of sodium hyaluronate and 3 g of carboxymethylcellulose were dissolved in 100 ml of water as a solvent to prepare a solution E of a hydrophilic coating material as an upper layer.

[0121] Next, under the same conditions as in Example 2, UV irradiation was performed on the front end portion of the same lead wire as in Example 1 and the coil member.

[0122] Next, this UV-irradiated portion was soaked in solution B containing the connection layer components, and then dried in a drying oven at 120° C. for 30 minutes to remove the solvent, thereby forming a connection between the coil member and the surface of the leading end portion. layer.

[0123] Next, the part where ...

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Abstract

An object of the present invention is to provide a guidewire preventing cracks from being generated at a hydrophilic coating agent and excellent in lubricity by securing flexibility of the hydrophilic coating agent on its surface side even in a case of using the cross-linked hydrophilic coating agent. The guidewire 1 includes a core shaft 2, a coiled body 3 provided at a tip portion of the core shaft 2, a most distal portion 4 fixing a front end of the core shaft 2 and a front end of the coiled body 3, and a hydrophilic coating agent 5 coating the coiled body 3 and the most distal portion 4 and cross-linked by a cross-linking agent 7. The degree of cross-linking of the hydrophilic coating agent 5 decreases from a side of the coiled body 3 toward a surface side.

Description

technical field [0001] This invention relates to wires formed with a lubricious surface. Background technique [0002] In the past, for the purpose of treatment or inspection, among guide wires used for guiding catheters inserted into tubular organs such as blood vessels, digestive tract, and urethra, or internal tissues, several types of guide wires have been proposed. The friction between the wires is provided with a hydrophilic coating on the surface of the wire. [0003] For example, Patent Document 1 (Japanese Patent Laid-Open Publication No. 2004-215709) describes a hydrogel formed by irradiating a solution in which a biocompatible polymer and a radiation-crosslinked polymer compound are dissolved. The hydrogel is formed. [0004] In addition, Patent Document 2 (Japanese Patent Laid-Open Publication No. 2008-125913) describes a wire using a covering material containing 2-acrylamide-2 - A crosslinked polymer of methylpropanesulfonic acid as the first monomer componen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M25/09
CPCA61L31/10A61M2025/09091A61M25/09A61M2025/09083A61L31/14A61M2025/09133A61L2400/10
Inventor 里崎顺二
Owner ASAHI INTECC CO LTD
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