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High-ventilated degradable medicine-carrying skin wound dressing as well as preparation method and device thereof

A technology for skin wounds and air permeability, which is applied in the field of highly air-permeable and degradable drug-loaded skin wound dressings and its preparation, to achieve good controlled release, prevent adhesion, and increase permeability

Active Publication Date: 2013-08-07
PKU HKUST SHENZHEN HONGKONG INSTITUTION +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

"Hemcon" is a medical hemostatic material processed with chitosan, but this material is made into a bandage type, which can only be used for superficial wounds, and cannot be used for larger and deeper wounds

Method used

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  • High-ventilated degradable medicine-carrying skin wound dressing as well as preparation method and device thereof
  • High-ventilated degradable medicine-carrying skin wound dressing as well as preparation method and device thereof
  • High-ventilated degradable medicine-carrying skin wound dressing as well as preparation method and device thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0023] The preparation of embodiment drug-loaded skin wound dressing

[0024] Specific process such as figure 1 Shown: First mix a certain amount of chitosan (0.5-1.2 grams), water (15-30 grams) and lactic acid (0.2-1 milliliters) at 40-60 O Stir at high speed with a magnetic stirrer in a constant temperature water bath for 4 hours, and the system is translucent golden yellow viscous; then put the colloidal solution into a watch glass, and put it in a low-temperature freezer (-78 O C) Freeze for 24 hours, and then use a freeze dryer to freeze-dry until fluffy and spongy, which is solid chitosan lactate.

[0025] Dissolve chitosan lactate with deionized water to make a 5-15% aqueous solution, add 1-5 grams of sodium hyaluronate solution, mix and stir; when the system appears uniform and transparent, add tert-butanol Appropriate amount (the concentration of tert-butanol is 3-15% of the whole system), and continue to stir; when the system appears uniform and transparent, add...

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Abstract

The invention discloses a highly air-permeable and degradable drug-loaded skin wound dressing and a preparation method and equipment thereof, belonging to the technical field of new medical materials. The highly air-permeable and degradable drug-loaded skin wound dressing of the present invention comprises components (percentage by weight): 45-50% of chitosan lactate; 45-50% of sodium hyaluronate; and 5-10% of antibiotics. The invention uses the composite material of chitosan lactate and sodium hyaluronate as the substrate, and is a porous bioactive dressing loaded with antibiotic drugs. Through the special freezing process, the dressing has vertical pores, high air permeability, high water absorption and moisture retention, thereby increasing the permeability of the wound surface, and can absorb excess exudate in time while keeping the moisture of the wound surface from excessive evaporation. . It plays a long-term and effective role in the treatment of wounds, thereby avoiding the pain caused by frequent dressing changes.

Description

technical field [0001] The invention belongs to the technical field of new medical materials, and in particular relates to a highly air-permeable and degradable drug-loaded skin wound dressing and a preparation method and equipment thereof. Background technique [0002] Generally, there are the following requirements for wound dressings: (1) have a softness similar to that of human skin, and can maintain a certain shape and strength when wet; (2) can maintain a moist environment on the wound surface, and have better absorption of wound secretions. (3) The dressing is non-toxic, does not cause harmful reactions and irritations to the human body, and must be able to prevent bacteria from entering the wound surface to prevent secondary infection, and avoid wound contact with particles and toxic pollutants , no heat source; (4) It is best to have hemostatic and pain-relieving effects, which can promote granulation growth and skin regeneration, accelerate healing, and reduce scar...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/28A61L15/42A61L15/44F25D3/10
Inventor 赖琛奚廷斐张志雄盛立远
Owner PKU HKUST SHENZHEN HONGKONG INSTITUTION
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