Aztreonam-compound-containing composition

A technology for aztreonam and a compound is applied in the field of a composition containing an aztreonam compound and the preparation thereof, which can solve the problems of poor stability of the aztreonam compound, and achieve the effects of good stability, simple preparation process and increased stability.

Active Publication Date: 2011-10-19
罗诚
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the deficiency of poor stability of aztreonam compound, the present invention provides a composition containing aztreonam compound with high stability and simple preparation process and a preparation method thereof

Method used

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  • Aztreonam-compound-containing composition

Examples

Experimental program
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Effect test

Embodiment 1

[0017] Get 4.35g aztreonam compound (manufactured by Wuhan Changheng Institute of Biology) and dissolve in 50ml mannitol (manufactured by Jinan Luli Chemical Co., Ltd.) to make aztreonam mannitol solution; get 3.27g aztreonam (made by Xingyinhe Pharmaceutical Chemical Co., Ltd.) was dissolved in 65ml of water to make an aqueous arginine solution; the aztreonam mannitol solution and the arginine aqueous solution were heated to 50°C in a water bath, and the arginine aqueous solution was added dropwise to the ammonia In Qunan mannitol solution, mix evenly and keep warm for 30 minutes; gradually cool to 10°C, add 0.2g vitamin C (manufactured by Wuhan Fuchi Biotechnology Co., Ltd.), and vacuum freeze-dry to obtain a composition containing aztreonam compound.

Embodiment 2

[0019] Get 4.35g aztreonam compound (manufactured by Wuhan Changheng Institute of Biology) and dissolve in 15ml mannitol (manufactured by Jinan Luli Chemical Co., Ltd.) to make aztreonam mannitol solution; get 3.92g aztreonam (made by Xingyinhe Pharmaceutical Chemical Co., Ltd.) was dissolved in 40ml of water to make an aqueous arginine solution; the aztreonam mannitol solution and the arginine aqueous solution were heated to 60°C in a water bath, and the arginine aqueous solution was added dropwise to the ammonia In the qunan mannitol solution, mix well and keep warm for 60 minutes; gradually cool to 15° C., add 3.8 g of vitamin C (manufactured by Wuhan Fuchi Biotechnology Co., Ltd.), and vacuum freeze-dry to obtain a composition containing aztreonam compound.

Embodiment 3

[0021] Get 4.35g aztreonam compound (made by Wuhan Changheng Institute of Biology) and dissolve in 30ml mannitol (made by Jinan Luli Chemical Co., Ltd.) to make aztreonam mannitol solution; get 3.60g aztreonam (made by Xingyinhe Pharmaceutical Chemical Co., Ltd.) was dissolved in 10ml of water to make an aqueous arginine solution; the aztreonam mannitol solution and the arginine aqueous solution were heated to 50°C in a water bath, and the arginine aqueous solution was added dropwise to the ammonia In the qunan mannitol solution, mix well and keep warm for 45 minutes; gradually cool to 20° C., add 7.0 g of vitamin C (manufactured by Wuhan Fuchi Biotechnology Co., Ltd.), and vacuum freeze-dry to obtain a composition containing aztreonam compound.

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Abstract

The invention relates to the field of medical chemistry, particularly an aztreonam-compound-containing composition and a preparation method thereof. The aztreonam-compound-containing composition comprises the following raw materials in certain weight: aztreonam compound, arginine, mannitol and antioxidant. The invention also provides a preparation method of the aztreonam-compound-containing composition, which comprises the following steps: dissolving aztreonam compound in mannitol to prepare an aztreonam mannitol solution; dissolving arginine in water for injection to prepare an arginine water solution; dropwisely adding the arginine water solution into the aztreonam mannitol solution at 50-60 DEG C, evenly mixing, and keeping the temperature for 30-60 minutes; and finally, adding antioxidant, and carrying out vacuum freeze drying to obtain the aztreonam-compound-containing composition. The aztreonam-compound-containing composition provided by the invention has the advantage of high stability, and the preparation method is simple and easy for operation.

Description

technical field [0001] The invention relates to the field of medicine and chemical industry, in particular to a composition containing an aztreonam compound and a preparation method thereof. Background technique [0002] Aztreonam compound is a synthetic monocyclic β-lactam antibiotic with high antibacterial activity against most aerobic Gram-negative bacteria, including Escherichia coli, Klebsiella pneumoniae and Oxy Enterobacteriaceae such as Trotobacter, Aerobacter, Cloacae, Proteus, Serratia, Citrobacter, Shigella and other Enterobacteriaceae bacteria, as well as influenza bacillus, Neisseria gonorrhoeae, Neisseria meningitidis, etc. Pseudomonas aeruginosa also has good antibacterial effect. Clinically, it is mainly used to treat various infections caused by sensitive aerobic gram-negative bacteria, such as: urinary tract infection, lower respiratory tract infection, sepsis, intra-abdominal infection, gynecological infection, postoperative wound and burn, ulcer and othe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/427A61K47/10A61K47/18A61K47/22A61P31/04
Inventor 罗诚
Owner 罗诚
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