Agent that modulates physiological condition of pests, involved in insect voltage-gated potassium channel activity

A technology of potassium channel and insecticidal activity, applied in the field of reagents involved in insect voltage-gated potassium channel activity to regulate the physiological status of pests, and can solve problems such as neuromuscular defects, gain-of-function mutations, movement and oviposition defects, etc.
CN102224166AInactive Publication Date: 2011-10-19SUMITOMO CHEM CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SUMITOMO CHEM CO LTD
Publication Date
2011-10-19
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention provides an agent that modulates physiological condition of pests, wherein the agent has an ability to modulate the activity of an insect voltage-gated potassium channel; a method for assaying pesticidal activity of a test substance, which comprises measuring the activity of a voltage-gated potassium channel in a reaction system in which the voltage-gated potassium channel contacts with a test substance; and so on.
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Description

technical field

[0001] The invention relates to a reagent for regulating the physiological state of pests, participating in the activity of insect voltage-gated potassium channels, and the like. Background technique

[0002] Voltage-gated potassium channels are membrane proteins that respond to membrane potential to selectively permeate potassium ions and are ubiquitous in animals, plants, and microorganisms, and include a variety of molecular species. According to the structural and physiological functional characteristics, the voltage-gated potassium channels are classified into many families, namely Shaker type, EAG (ether-a-go-go) type, KvLQT, etc. (Gutman et al., Pharmacol. Reviews (Pharmacological Reviews) , 55(4):583-586, 2003).

[0003] Seizure is the insect homologue of human ERG (hERG) and a member of the EAG family of voltage-gated potassium channels. The EAG family consists of three subfamilies EAG (ether-a-go-go), ERG (EAG-related genes) and ELK (EAG-like gene...

Claims

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