Ginkgo biloba-ginseng vein relaxing capsule and preparation method thereof

A technology of capsules and silver ginseng, applied in the field of medicine, can solve the problems of unsatisfactory stability and efficacy, and achieve the effects of inhibiting platelet aggregation, protecting myocardial ischemia, and improving the activity of myocardial metabolic enzymes.

Inactive Publication Date: 2011-11-02
TIANSHENG PHARMA GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The drug stability and efficacy of the pharmaceutical preparations currently on the market for the treatment of coronary heart disease and angina pectoris are not satisfactory

Method used

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  • Ginkgo biloba-ginseng vein relaxing capsule and preparation method thereof
  • Ginkgo biloba-ginseng vein relaxing capsule and preparation method thereof
  • Ginkgo biloba-ginseng vein relaxing capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A Yinshen Tongluo capsule, which contains the effective ingredients of ginkgo biloba, ginseng, chuanxiong and schisandra, and its preparation process is:

[0027] Weigh the components as follows:

[0028]

[0029] Add 8 times the weight of a 75% ethanol solution to the above amount of ginkgo leaves, control the temperature at 75°C, reflux for extraction for 90 minutes, and filter; add 8 times the weight of the ginkgo leaves to the medicine residue. Divide the ethanol solution with a concentration of 75%, control the temperature at 75°C, reflux for 90 minutes, filter, combine the extracts, control the temperature at 45°C, evaporate, recover the ethanol, and concentrate to 2 to 3 times the amount of the raw material (relative density 1.15) , That is, Ginkgo biloba extract.

[0030] After smashing ginseng, chuanxiong and schisandra medicinal materials, add 8 times the amount of deionized water, heat at 93 ℃ to keep slightly boiling, decoct and keep for 1 to 2 hours, filter the b...

Embodiment 2

[0033] A Yinshen Tongluo capsule contains ginkgo biloba, ginseng, chuanxiong and schisandra, and the parts by weight of each component are as follows:

[0034]

[0035] The preparation process is:

[0036] Add 8 times the weight of the 75% n-butanol solution to the above-mentioned amount of ginkgo leaves, control the temperature at 80°C, reflux for extraction for 60 minutes, and filter; add 10 times the amount of the ginkgo leaves to the medicine residue 75% volume percentage of n-butanol solution, controlled temperature 80 ℃ reflux extraction for 70 minutes, filter, combine the extracts, control temperature 60 ℃, evaporate, recover n-butanol, concentrate to 2 to 3 times the amount of raw materials (The relative density is 1.15), and the Ginkgo biloba extract is obtained.

[0037] After smashing ginseng, chuanxiong and schisandra, add 8 times the amount of deionized water, heat at 90°C to keep slightly boiling, decoct and keep for 2 hours, filter the cooking liquor to obtain the fil...

Embodiment 3

[0040] A Yinshen Tongluo capsule contains ginkgo biloba, ginseng, chuanxiong and schisandra, and the parts by weight of each component are as follows:

[0041]

[0042]

[0043] The preparation process is:

[0044] Add 10 times the volume percentage of 95% ethanol solution to the above amount of ginkgo biloba, control the temperature at 75°C, reflux for extraction for 70 minutes, and filter; add 9 times the volume percentage of the ginkgo leaves to the medicine residue Concentration of 95% ethanol solution, reflux and extract at 77°C for 70 minutes, filter, combine the extracts, control temperature at 55°C, evaporate, recover ethanol, and concentrate to 2.5 times the amount of raw material (relative density is 1.15) to get Ginkgo biloba extract.

[0045] After crushing the above ginseng, chuanxiong and schisandra, add 9 times the amount of deionized water, heat at 94℃ to keep slightly boiling, decoct and keep for 1 hour, filter the cooking liquor to obtain the filtrate; add 10 times...

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Abstract

The invention relates to a ginkgo biloba-ginseng vein relaxing capsule. The capsule is prepared through the following steps: well mixing, granulating, drying, and crushing ginkgo biloba, ginseng, Ligusticum wallichii and Schisandra chinensis extracts which account for 65 to 85 wt% of the ginkgo biloba-ginseng vein relaxing capsule and a filler which accounts for 10 to 30 wt% of the capsule; and adding a lubricant which accounts for 1 to 5 wt% of the capsule, adjusting an automatic capsule filling machine, and filling into a capsule. The ginkgo biloba-ginseng vein relaxing capsule of the present invention has a good quality stability because contents of total flavonoid alcoholic glycosides and total terpene lactones are undifferentiated between a twelfth month and a zero month through long-term stability determination testing, and the contents of the total flavonoid alcoholic glycosides and the total terpene lactones are undifferentiated between a sixth month and a zero month through accelerated stability determination testing. According to pharmacological pharmacodynamics testing results, the capsule has an obvious protective effect on myocardial ischemia caused by coronary artery ligation, allows the degree of myocardial infarction to be alleviated, and sT segment elevation caused by acute myocardial ischemia to be inhibited, so the results provide main pharmacodynamics testing basis for preventing and curing coronary heart disease, angina and myocardial infarction with the capsule.

Description

Technical field [0001] The invention relates to a Chinese patent medicine for treating coronary heart disease and angina pectoris and a preparation method thereof, in particular to a Yinshen Tongluo capsule and a preparation method thereof, and belongs to the technical field of medicine. Background technique [0002] Coronary heart disease is a common cardiovascular disease in clinical practice. At the beginning of the 20th century, coronary heart disease was the first cause of disability and death in Americans. Since the 1960s, with the advancement of medical and health services and the improvement of medical conditions, the incidence and mortality of coronary heart disease in Western developed countries have been declining year by year. Trends, coronary heart disease has retreated from the top ten causes of death to the third place, but according to the 1996 American Heart Association report, in the United States, one person still dies from cardiovascular disease every 33 secon...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/57A61K9/48A61P9/10
Inventor 李朝阳向洪昝琼
Owner TIANSHENG PHARMA GROUP
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