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Preparation method for macroporous hydroxyapatite ceramic

A technology of macroporous hydroxyapatite and hydroxyapatite, which is applied in the field of ceramic materials, can solve the problems of easy introduction of impurities and inflexible control of pore structure, and achieves the effects of simplified process, low cost and easy control.

Inactive Publication Date: 2011-11-02
NORTHEASTERN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Based on the above analysis and summary of the current status of the preparation of macroporous hydroxyapatite, it can be seen that its preparation mainly relies on the use of pore-forming agents and template agents, and has disadvantages such as easy introduction of impurities and inflexible control of pore structure.

Method used

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  • Preparation method for macroporous hydroxyapatite ceramic
  • Preparation method for macroporous hydroxyapatite ceramic
  • Preparation method for macroporous hydroxyapatite ceramic

Examples

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Effect test

Embodiment 1

[0037] Example 1: Using a homogeneous aqueous solution of polyvinyl alcohol 2099 (the degree of polymerization is 2000, and the degree of alcoholysis is 99%) with a concentration of 6.75wt% is used as a binder, and concentrated hydrochloric acid (37%, mass fraction) is used to adjust the polyvinyl alcohol After the pH value reaches 6, add hydroxyapatite, powder with a particle size of 100 nanometers and polyvinyl alcohol aqueous solution at a mass ratio of 4:22 into a polypropylene tank, without adding surfactant lauryl sulfate Sodium: Add corundum balls according to the ball-to-material ratio of 1.5:1, seal, slowly mix until uniform, and then oscillate for 0.5 hours, and transfer the uniformly oscillated slurry to -17 o C, put in the freezer and continue to freeze for 9 hours. Transfer the frozen sample directly to anhydrous or industrial ethanol to extract the water in the sample. The extraction time is 5 hours. This extraction process is repeated again, and then the sample ...

Embodiment 2

[0039] Embodiment 2: The preparation process is the same as that of Example 1, except that hydroxyapatite, whose particle size is 100 nanometers, is mixed with polyvinyl alcohol aqueous solution at a mass ratio of 4.5:22;

[0040] Depend on image 3 It can be seen that the macropore diameter of the macroporous hydroxyapatite ceramics prepared in this embodiment is 120 μm. When the content of polyvinyl alcohol is constant, the increase of the amount of hydroxyapatite will cause the increase of the pore diameter, and the connectivity is better; Figure 4 The laser confocal optical photographs clearly show that the diameter of the communication holes between the macropores is 30-70 μm.

Embodiment 3

[0041] Example 3: The difference between the preparation process and Example 1 is that after shaking for 0.5 hours, mechanical stirring was carried out for 10 minutes, and the rotation speed was 1200 rpm.

[0042] Depend on Figure 5 It can be seen that the macropore diameter of macroporous hydroxyapatite ceramics prepared in this example is 150-200 μm. When the content of hydroxyapatite is constant, the increase of polyvinyl alcohol will gradually increase the pore size, and the pore wall will gradually become thinner, and the connectivity will be improved. better.

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Abstract

The invention relates to the technical field of ceramic materials, in particular to a preparation method for macroporous hydroxyapatite ceramic. The preparation method comprises the following steps of: firstly preparing an uniform bonder polyvinyl alcohol aqueous solution, adjusting the pH value of the polyvinyl alcohol to be 4-5.5 by using concentrated hydrochloric acid, mixing the HA (hydroxyapatite) powder and the polyvinyl alcohol aqueous solution according to the mass ratio of (2-5): (10-20) to form a uniform sizing, and adding surfactant, i.e. lauryl sodium sulfate; adding the sizing into a polypropylene tank, sealing the polypropylene tank after adding corundum globules according to a ball-to-powder weight ratio of 1.5:1, slowly mixing the sizing till being uniform; then uniformly oscillating or mechanically stirring the sizing, and introducing air bubbles; transferring the sizing uniformly oscillated to a container of -17 DEG C, after freezing for 4 to 12 hours, extracting water in the frozen sizing at the room temperature or freezing condition, and then drying the sizing; and finally finishing sintering in air; wherein the sintering temperature is 1000-1200 DEG C, and the heat preservation time is 0.5-2h.

Description

technical field [0001] The invention relates to the technical field of ceramic materials, in particular to a preparation method of macroporous hydroxyapatite ceramics. Background technique [0002] Biomaterials are materials that come into contact with tissues to form functions for medical purposes. Bioceramics, as an important biomaterial, usually refers to ceramics for bone tissue engineering such as artificial tooth production, bone and cartilage and other tissue repair, defect filling, and spinal surgery. Among them, hydroxyapatite (HA) and tricalcium phosphate (TCP) exhibit excellent biocompatibility and biosafety due to their inorganic components similar to natural bone tissue, and can form with bone tissue after implantation. Osteobonding, known as bioactive materials, has been used as a material for bone repair. Academician Zhang Xingdong's research group used porous active bioceramics to treat 40 cases of bone defects and achieved satisfactory results (Zhang Cong ...

Claims

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Application Information

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IPC IPC(8): C04B35/447C04B35/622
Inventor 王伟常青楚宝帅林春青陈思茹红强
Owner NORTHEASTERN UNIV
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