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Traditional Chinese medicine composite for treating gstrointestinal dysfunction and preparation method thereof

A technology for gastrointestinal dysfunction and composition, which is applied in the field of traditional Chinese medicine compositions for the treatment of gastrointestinal dysfunction and its preparation field, can solve the problems of inconvenience, disadvantage, unstable active ingredients, etc., and achieves small dosage and cost saving , the effect of easy quality control

Inactive Publication Date: 2011-11-23
NANJING ZHONGKE PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above ancient prescriptions are all decocted with water and used in clinical decoction, which is not only inconvenient for patients to use, but also unfavorable to retain the unstable active ingredients in the medicine

Method used

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  • Traditional Chinese medicine composite for treating gstrointestinal dysfunction and preparation method thereof
  • Traditional Chinese medicine composite for treating gstrointestinal dysfunction and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] Atractylodes macrocephala, Radix Paeoniae Alba, tangerine peel, and windproof traditional Chinese medicine are respectively pulverized into coarse powder, and extracted by a carbon dioxide supercritical extraction device. Put the coarse powder into the extraction tank, set the extraction pressure to 30MPa, the extraction temperature to 50°C, press CO 2 Gas cylinder→cooling system→high pressure pump→extraction tank→separator I→separator II→circulation for supercritical extraction until no extract is produced, and the extract is collected from the separator to obtain Atractylodes macrocephala extract, Paeoniae officinalis extract, tangerine peel extract and windproof extract;

[0058] The composition of the present invention is obtained by taking Atractylodes macrocephala extract, Radix Paeoniae Alba extract, tangerine peel extract and Fangfeng extract respectively and mixing them in a weight ratio of 1:1:1:1. Tablets are prepared by adding appropriate excipients.

Embodiment 2

[0060] The coarse powder of Atractylodes macrocephala is put into the extraction tank, the extraction pressure is set to 33MPa, the extraction temperature is 43°C, and the carbon dioxide supercritical extraction device is used for extraction. Press CO 2 Gas cylinder→cooling system→high pressure pump→extraction tank→separator I→separator II→circulation for supercritical extraction, extraction for 90min. Collect the Atractylodes macrocephala extract from the separator.

[0061] The coarse powder of tangerine peel is put into the extraction tank, the extraction pressure is set to 32MPa, the extraction temperature is 47°C, and the carbon dioxide supercritical extraction device is used for extraction. Press CO 2 Gas cylinder→cooling system→high pressure pump→extraction tank→separator I→separator II→circulation for supercritical extraction, extraction for 120min. Collect the tangerine peel extract from the separator.

[0062] Put the windproof coarse powder into the extraction t...

Embodiment 3

[0066] The coarse powder of Atractylodes macrocephala is put into the extraction tank, the extraction pressure is set to 31MPa, the extraction temperature is 40°C, and the carbon dioxide supercritical extraction device is used for extraction. Press CO 2 Gas cylinder→cooling system→high pressure pump→extraction tank→separator I→separator II→circulation for supercritical extraction, extraction for 80min. Collect the Atractylodes macrocephala extract from the separator.

[0067] The coarse powder of tangerine peel is put into an extraction tank, the extraction pressure is set to 34MPa, the extraction temperature is 45°C, and a carbon dioxide supercritical extraction device is used for extraction. Press CO 2 Gas cylinder→cooling system→high pressure pump→extraction tank→separator I→separator II→circulation process for supercritical extraction, extraction 100min. Collect the tangerine peel extract from the separator.

[0068] Put the windproof coarse powder into the extraction ...

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Abstract

The invention discloses a traditional Chinese medicine composite for treating gstrointestinal dysfunction and a preparation method thereof. The traditional Chinese medicine composite is characterized in that the composite is composed of the following components in parts by weight: 1-6 parts of rhizoma atractylodis macrocephalae extract, 1-4 parts of radix paeoniae alba extract, 1-3 parts of pericarpium citri reticulatae extract and 1-3 parts of divaricate saposhnikovia extract, wherein the extracts are coarse powder obtained by smashing the traditional Chinese medicine and are extracted with a carbon dioxide supercritical extraction method. The traditional Chinese medicine composite disclosed by the invention fully extracts effective ingredients, and the pharmacological effect is superiorto the single-component extract, is superior to a full-formula carbon dioxide supercritical extract, and is superior to the composite of volatile oil ingredients and water extract ingredients appliedin the prior art, or the composite of volatile oil ingredients and ethanol extract ingredients.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and relates to a traditional Chinese medicine composition for treating gastrointestinal dysfunction and a preparation method thereof. Background technique [0002] Gastrointestinal dysfunction is a common clinical functional intestinal disease, accounting for about 30% of gastrointestinal diseases, especially in young and middle-aged people. The prevalence of gastrointestinal dysfunction in adults is 10% to 22%, and it is slightly more common in women. Its main clinical manifestations are abdominal pain, diarrhea, constipation and other digestive system symptoms. The etiology is gastrointestinal dysfunction. With the quickening of people's pace of life, the prevalence of the disease is on the rise. The treatment methods currently used mainly include psychotherapy, diet therapy and drug therapy. Because modern medicine is still unclear about its pathology and pathogenesis, although ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/752A61P1/00
Inventor 钱一帆杨星昊吴建波朱韵韵
Owner NANJING ZHONGKE PHARMA
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