Preparation of Adriamycin Hydrochloride Nanoliposome Preparation

A technology of nano-liposome and doxorubicin hydrochloride, which is applied in the directions of liposome delivery, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc. , the difficulty of chemotherapy drugs, etc., to achieve the effect of facilitating large-scale production, reducing the dosage, and increasing the stability

Inactive Publication Date: 2011-11-30
中南大学肝胆肠外科研究中心 +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Therefore, preparing doxorubicin into a drug with a particle size of 80-100nm, and then encapsulating it in liposomes can overcome the disadvantages of conventional chemotherap

Method used

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  • Preparation of Adriamycin Hydrochloride Nanoliposome Preparation
  • Preparation of Adriamycin Hydrochloride Nanoliposome Preparation
  • Preparation of Adriamycin Hydrochloride Nanoliposome Preparation

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Embodiment 1

[0024] A doxorubicin hydrochloride nanoliposome provided by the invention is achieved through the following measures.

[0025] a Alcohol injection-pH gradient method:

[0026] Prescription: Adriamycin Acid 1.0g

[0027] Yolk Lecithin 10.0g

[0028] Cholesterol 5.0g

[0029] Ethanol 200mL

[0030] Vitamin E 0.25g

[0031] Citric acid 32.0g

[0032] Disodium hydrogen phosphate 154.0g

[0033] Tween-80 10.0g

[0034] Glucose 50.0g

[0035] Water for injection 1000mL

[0036] The preparation process is as follows:

[0037] Egg yolk lecithin, cholesterol, vitamin E, and emulsifier are dissolved in absolute ethanol to form a lipid solution, and doxorubicin hydrochloride is dissolved in citric acid solution. 2 Standby, under the condition of high-speed stirring, use an injection needle to inject the lipid solution into the citric acid solution containing doxorubicin hydrochloride, wash the beaker with hot ethanol, inject...

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Abstract

The invention relates to the field of medicinal preparations, in particular to a preparation method for a nanoliposome preparation of doxorubicin hydrochloride or doxorubicin. The preparation mainly comprises doxorubicin, egg yolk lecithin, cholesterol, an antioxidant, a buffer, sugar, injection water and the like. A preparation process comprises steps of preparation of blank liposome and doxorubicin nanoliposome, a process optimization step and the like. Freeze-dried powder prepared by the invention has high entrapment efficiency, high stability and a simple and practical preparation process.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a method for preparing doxorubicin hydrochloride or nano liposomes of doxorubicin. Background technique [0002] The molecular structural formula of doxorubicin is as follows: [0003] [0004] Doxorubicin (hereinafter referred to as DOX), also known as daunorubicin, oxybutamycin, and doxorubicin, is an anthracycline anti-malignant tumor antibiotic commonly used in clinic, with broad anti-tumor spectrum, strong activity and good curative effect. Its mechanism of action is mainly that DOX molecules intercalate into DNA and inhibit the synthesis of nucleic acids. [1] . DOX can produce a wide range of biochemical effects on the body, so it is widely used in the treatment of acute leukemia, non-Hodgkin's lymphoma, breast cancer, small cell lung cancer, gastric cancer, liver cancer, ovarian cancer and sarcoma and other malignant tumors [2] . However, after intravenous...

Claims

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Application Information

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IPC IPC(8): A61K9/127A61K31/704A61K47/24A61K47/28A61P35/00A61P35/02
Inventor 龚连生张阳德何剪太张浩伟汪建荣刘殿奎周艳琴
Owner 中南大学肝胆肠外科研究中心
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