Preparation method of Jichuan pills
A technology of dropping pills and large drops is applied in the directions of non-active ingredient medical preparations, medical preparations containing active ingredients, and pill delivery, etc., to achieve the effects of improving the dissolution time limit, increasing the dispersibility, and high bioavailability.
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Embodiment 1
[0029] The preparation method of Jichuan Dadropping Pills comprises the following steps:
[0030] 1) In terms of parts by mass, after mixing 3 parts of Angelica sinensis, 1 part of Achyranthes bidentata, 2 parts of Cistanche, 1 part of Alisma, 1 part of Cimicifuga, and 1 part of Fructus Citrus Fructus, add 8 times its mass concentration of 60 Ethanol, reflux extraction for 2 hours, separate the alcohol extract and add 60% ethanol to extract once again, filter and separate the alcohol extract after the extraction is completed, combine the alcohol extract twice, and concentrate the alcohol extract under reduced pressure to a relative density of 1.0-1.1 g / cm 3 (measured at 80°C) alcohol-extracted extract;
[0031] 2) Spray-dry the alcohol-extracted extract, the air inlet temperature is 210° C., and the air outlet temperature is 110° C. during spray drying to obtain intermediate drug powder.
[0032] 3) Mix polyethylene glycol 4000 and polyoxyl 40 stearate at a mass ratio of 10:...
Embodiment 2
[0034] The preparation method of Jichuan Dadropping Pills comprises the following steps:
[0035] 1) In terms of parts by mass, after mixing 4 parts of Angelica sinensis, 2 parts of Achyranthes bidentata, 3 parts of Cistanche, 2 parts of Alisma, 2 parts of Cimicifuga, and 2 parts of Citrus aurantium, add 10 times its mass concentration to be 70% of ethanol, reflux extraction for 3 hours, separate the alcohol extract and add 65% ethanol to extract once again, filter and separate the alcohol extract after the extraction is completed, combine the two alcohol extracts, and concentrate the alcohol extract under reduced pressure to a relative density of 1.0~ 1.1g / cm 3 (measured at 80°C) alcohol-extracted extract;
[0036] 2) Spray-dry the alcohol-extracted extract, the air inlet temperature is 200° C., and the air outlet temperature is 110° C. during spray drying to obtain intermediate drug powder.
[0037] 3) Mix polyethylene glycol 4000 and polyoxyl 40 stearate at a mass ratio o...
Embodiment 3
[0039] The preparation method of Jichuan Dadropping Pills comprises the following steps:
[0040]1) In terms of parts by mass, after mixing 5 parts of Angelica sinensis, 3 parts of Achyranthes bidentata, 4 parts of Cistanche, 3 parts of Alisma, 3 parts of Cimicifuga, and 3 parts of Citrus aurantium, add 12 times its mass concentration to be 65% of ethanol, reflux for extraction for 4 hours, add 65% ethanol to extract once after separating the alcohol extract, filter and separate the alcohol extract after the extraction is completed, combine the two alcohol extracts, and concentrate the alcohol extract under reduced pressure to a relative density of 1.0~ 1.1g / cm 3 (measured at 80°C) alcohol-extracted extract;
[0041] 2) Spray-dry the alcohol-extracted extract, the air inlet temperature is 220° C., and the air outlet temperature is 120° C. during spray drying to obtain intermediate drug powder.
[0042] 3) Mix polyethylene glycol 4000 and polyoxyl 40 stearate at a mass ratio ...
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