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an interventional medical device

一种医疗器械、涂层的技术，应用在医疗器械领域，能够解决生物相容性差、血栓及术后并发症、复杂生物相容性等问题，达到细胞相容性增强的效果

Active Publication Date: 2011-12-14
SHANGHAI MICROPORT MEDICAL (GROUP) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, due to the complexity of the physiological structure in the human body, the application of interventional medical devices in the human body also has complex biocompatibility issues. In addition, when polymer materials are coated on interventional medical devices, they will also Biocompatibility issues in vivo
At present, the commonly used polymer materials mainly include polymethacrylate polymers, fluoropolymers, polyethylene polymers or polystyrene polymers. These polymers are used in industrial applications at the beginning of their application and are biocompatible. Poor sex
[0005] Therefore, after the existing interventional medical devices are implanted in the human body for a long time, due to poor biocompatibility, it will lead to more serious thrombosis and postoperative complications.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] figure 1 It is a schematic structural diagram of an interventional medical device provided in Embodiment 1 of the present application.

[0036] Such as figure 1 As shown, the interventional medical device includes a stent body 1 and a coating 2 disposed on the outer surface of the stent body 1, wherein: the material of the coating 2 is a polymer containing sulfonic acid groups.

[0037] In the embodiment of the present application, the polymers containing sulfonic acid groups used in coating 2 include but are not limited to sulfonated thermoplastic elastomers, preferably sulfonated styrene-olefin copolymers, more preferably styrene-isobutylene di Block or tri-block copolymer, wherein the weight percentage of styrene is 25-55%. In addition, the sulfonated thermoplastic elastomer can also be other copolymers well known to those skilled in the art.

[0038] In the embodiment of the present application, the sulfonation rate in the polymer containing sulfonic acid groups ...

Embodiment 2

[0041] figure 2 It is a schematic structural diagram of an interventional medical device provided in Embodiment 2 of the present application.

[0042] Such as figure 2 As shown, the interventional medical device includes a stent body 1, an outermost coating 2 and an inner coating 3 coated on the outer surface of the stent body 1, wherein: the material of the outermost coating 2 is a material containing a sulfonic acid group polymer, and the sulfonation rate of the polymer containing sulfonic acid groups used in the outermost coating layer 2 is 5% to 30%, more preferably 10% to 20%.

[0043]The material of inner layer coating 3 can be inorganic coating, organic coating or traditional polymer coating, also can be the polymer coating that contains sulfonic acid group, when the material of inner layer coating 3 is to contain sulfonic acid group When using agglomerated polymers, since the environment of the inner coating 3 and the outermost coating 2 are different, the requirem...

Embodiment 3

[0045] image 3 It is a schematic structural diagram of an interventional medical device provided in Example 3 of the present application.

[0046] Such as image 3 As shown, on the basis of the second embodiment, a layer of primer coating 4 may be added between the inner coating layer 3 and the stent body 1 as required.

[0047] Like the inner coating 3 in the second embodiment, the material of the bottom coating 4 can also be an inorganic coating, an organic coating or a traditional polymer coating, and can also be a polymer coating containing sulfonic acid groups. When the material of the primer coating 4 is a polymer containing sulfonic acid groups, the sulfonation rate of the polymer containing sulfonic acid groups in the primer coating 4 should be controlled below 15%, preferably 5-10%.

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Abstract

The present invention discloses an interventional medical device and methods of making the same. At least one coating layer is disposed on the outer surface of the interventional medical device and the material of the outmost layer of the coating layer is a sulfonate group-containing polymer. In the present invention, the material of the outmost layer of the interventional medical device is a sulfonate group-containing polymer. The polymer is endowed with a same surface property as that of heparin in addition to appropriate hydrophilicity due to the presence of the sulfonate group. After the interventional medical device is implanted into the human body, a hydrophilic surface is formed on the outer surface of the interventional medical device which is also negatively charged in the body fluid. Therefore, cells can easily adhere and grow on the outer surface thereof as a result of the enhanced cell compatibility. Furthermore, due to a surface property that is the same as that of heparin, the material is provided with excellent anticoagulant properties which inhibit the thrombosis and lower down the incidence rate of post-operational complications.

Description

technical field [0001] The present application relates to the field of medical devices, in particular to an interventional medical device. Background technique [0002] Interventional medical devices are emerging medical device technologies in the past two decades, which play a very important role in reducing trauma to patients and improving disease treatment effects. For example, interventional devices used in various lumens of the human body, such as vascular stents, biliary stents, esophageal stents, intestinal stents, pancreatic duct stents, urethral stents or tracheal stents, etc., as well as corresponding interventional catheters, balloons, filters Wait. Among them, the performance of stents in the field of interventional medical devices is particularly prominent. For vascular diseases caused by vascular obstruction or other reasons, stents have been proved to be a relatively successful interventional medical device for long-term implantation in blood vessels. Durin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/04A61F2/82
CPCA61L27/34A61L31/16A61L27/54A61L2300/42A61L31/10
Inventor 李俊菲胡玺乐承筠王大伟黄鹏唐智荣罗七一常兆华
Owner SHANGHAI MICROPORT MEDICAL (GROUP) CO LTD
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