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Method for preparing porous calcium phosphate biological ceramic material

A bioceramic material, porous calcium phosphate technology, applied in the field of materials and biomedicine, can solve the problems of easy inflammation, residual plastic particles, complex process, etc., and achieve uniform pore size and pore distribution, simple method and high purity. Effect

Inactive Publication Date: 2013-07-03
CHONGQING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method is complex and will leave plastic particles, which can easily cause inflammation

Method used

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  • Method for preparing porous calcium phosphate biological ceramic material
  • Method for preparing porous calcium phosphate biological ceramic material
  • Method for preparing porous calcium phosphate biological ceramic material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Put OCP (octacalcium phosphate) powder into a stainless steel mold, compact it under the condition of a pressure of 20MPa, then keep it under this pressure for 10min, and take out the green body; o C / min heating rate to 300 o Sinter at C, vaporize to remove crystal water, keep at this temperature for 2 hours and then heat to 900 o C undergoes a phase transition, and then naturally cools in the furnace to obtain a β-TCP porous bioceramic with a pore size of 1–5 μm and a porosity of 22%.

Embodiment 2

[0039] Put DCPD (calcium hydrogen phosphate dihydrate) powder into a stainless steel mold, compact it under the condition of a pressure of 20 MPa, and then keep it under this pressure for 10 minutes, and take out the green body; o C / min heating rate to 300 o Sinter at C, vaporize to remove crystal water, keep at this temperature for 2 hours and then heat to 900 o C undergoes a phase transition, and then naturally cools in a furnace to obtain a porous HA bioceramic with a pore size of 1–5 μm and a porosity of 37%.

Embodiment 3

[0041] Mix OCP and DCPD powders at a ratio of 1:1, put the mixed powder into a stainless steel mold, compact it under the condition of a pressure of 20MPa, and then keep it under the pressure for 10min, and take out the green body; after compaction, get The green body is 20 o C / min heating rate to 300 o Sinter at C, vaporize to remove crystal water, keep at this temperature for 2 hours and then heat to 900 o C undergoes a phase transition, and then naturally cooled in a furnace to obtain a biphasic porous bioceramic of β-TCP and HA with a pore size of 1–5 μm and a porosity of 29%.

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Abstract

The invention discloses a method for preparing a porous calcium phosphate biological ceramic material. The method comprises the following steps of: 1) adding a hydroxylapatite pre-phase into a die casting mould, compacting and keeping certain time, and taking a compacted green body out; and 2) raising the temperature of the compacted green body to 200 to 500 DEG C and sintering, keeping the temperature for 0.5 to 2h, heating to the temperature at which the hydroxylapatite pre-phase can be changed, stopping heating after the temperature at which the phase change can be ensured is reached, and naturally cooling the green body to room temperature in sintering equipment to obtain the porous calcium phosphate biological ceramic material. The process is simple and is high in controllability, the purity is high, and the strength of the material is influenced slightly. The porous biological ceramic material prepared by the method has better biocompatibility and bioactivity.

Description

technical field [0001] The invention relates to a preparation method of a porous calcium phosphate bioceramic material, which belongs to the field of materials and biomedicine. Background technique [0002] Clinically, artificial bone scaffolds are used to artificially repair damaged or diseased human bone tissue, which may lead to the spread of other diseases. Compared with metal stents and polymer stents, bioceramic stents do not have free metal ions, and have better biocompatibility and non-toxicity; while some polymer stents, their degradation products may cause inflammation. Calcium phosphate bioceramics (hydroxyapatite HA and tricalcium phosphate β-TCP) are mainly used as artificial bone scaffolds for the repair and reconstruction of hard tissue defects, and have broad application prospects in the medical field. [0003] Dense bioceramics usually have no microstructure suitable for tissue and cell growth, and their biodegradability and osteoconductivity are poor. In ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C04B38/08C04B35/447C04B35/622
Inventor 辛仁龙左蔼龄高家诚
Owner CHONGQING UNIV
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