Blended copolymer gel with capillary self-coating effect and preparation method thereof

A copolymer and capillary technology, which is applied in the field of blended copolymer gel and its preparation, can solve the problems that the uniform distribution of the two polymers cannot be guaranteed, the coating ability of the random copolymer is different, and the product quality is difficult to guarantee.
CN102276853BActive Publication Date: 2013-03-27INST OF FORENSIC SCI OF MIN OF PUBLIC SECURITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
INST OF FORENSIC SCI OF MIN OF PUBLIC SECURITY
Publication Date
2013-03-27

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Abstract

The invention discloses a blended copolymer gel with a capillary self-coating effect and a preparation method thereof. According to the preparation method, the blended copolymer gel is obtained by mixing a self-coating polymer with a screening polymer which polymerizes self-coating polymer monomers in a sol buffer. The blended copolymer gel prepared with the preparation method has a good separation capability and a capillary inner wall self-coating capability in the process of capillary electrophoresis, so the adsorption of the capillary inner wall to DNA molecules is effectively reduced, andthe service life of the capillary is increased.
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Description

technical field

[0001] The invention relates to a blended copolymer gel with capillary self-coating function and a preparation method thereof. Background technique

[0002] Capillary electrophoresis is a fast and efficient separation method. Charged species move from one end of the capillary to the other under the action of an electric field.

[0003] Capillary gel electrophoresis is one of the most effective methods for separating macromolecules, such as biological macromolecules RNA and DNA, peptides, proteins, etc. Capillary gel electrophoresis usually uses quartz capillaries with an inner diameter ranging from 50 microns to 200 microns and a length from 10 cm to 100 cm. In order to protect the analyte from being adsorbed and eliminate the electroosmotic flow of the capillary, the inner wall of the capillary is usually coated with a protective layer. The most commonly used coating is polyacrylamide coating. The properties of the separation medium of capillary gel elec...

Claims

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