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Novel Skin Cream Using Sodium Fusidate, Antifungals, and Steroids

A technology of sodium fusidate and fusidic acid, applied in the field of bacterial skin infection and inflammation, can solve the problems of stability, heat instability, roughness, uneven particle size, etc.

Inactive Publication Date: 2011-12-21
苏鲁・苏布拉马尼・瓦南加穆迪
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, fusidic acid precipitates are difficult to process into cream form, the first reason is its coarse and uneven particle size, and the second reason is that the recovery of fusidic acid from wet cake involves drying and further processing, which causing fusidic acid to be destroyed by exposure to oxygen
[0013] The stability of the API in fusidic acid cream is unreliable due to the thermolabile nature of fusidic acid

Method used

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  • Novel Skin Cream Using Sodium Fusidate, Antifungals, and Steroids
  • Novel Skin Cream Using Sodium Fusidate, Antifungals, and Steroids
  • Novel Skin Cream Using Sodium Fusidate, Antifungals, and Steroids

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Embodiment approach

[0598] 1. A novel skin cream comprising at least one corticosteroid, at least one antifungal agent, and fusidic acid prepared in situ using sodium fusidate in an oxygen-free environment, wherein said cream Including fusidic acid made by in situ conversion of sodium fusidate and a cream base comprising at least one of the following: preservatives; primary and secondary emulsifiers; waxy materials ; a co-solvent; an acid; and water, preferably purified water.

[0599] 2. The novel skin cream according to item 1, wherein the corticosteroid is present in an amount ranging from about 0.001% (w / w) to about 5% (w / w), preferably from about 0.005% (w / w) to about 2.00% (w / w), and most preferably about 0.05% (w / w) to 1.0% (w / w),

[0600]Described antifungal drug is with about 0.01% (w / w) to about 10% (w / w), preferably about 0.1% (w / w) to about 5.00% (w / w), and most preferably about 1% ( w / w) to 2.0% (w / w), and the fusidic acid is added in an amount of about 0.1% (w / w) to about 25% (w / w...

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Abstract

The present invention discloses a skin cream comprising an antifungal agent, a steroid and an antibacterial agent in the form of fusidic acid formed in situ with sodium fusidate as a starting material, wherein fusidic acid Sodium acid is converted to fusidic acid in the absence of oxygen. The cream of the present invention has higher shelf-life stability and finer API particle size than conventional creams containing fusidic acid. The cream of the present invention comprises as API fusidic acid and steroids which have been formed in situ from sodium fusidate in a cream base comprising acids, co-solvents, emulsifiers and waxy materials and Water, preferably purified water.

Description

technical field [0001] The present invention relates to primary and secondary bacterial skin infections and inflammations, and in particular to single-dose treatment with steroid and antifungal creams also comprising an antibacterial agent in the form of fusidic acid, wherein The acid has been prepared using sodium fusidate as the starting active pharmaceutical ingredient (API). Background technique [0002] Steroids are known to be used to reduce inflammation, irritation and itching caused by skin disorders. Steroid use is also known to compromise a patient's immune system and expose the patient to the risk of bacterial and fungal infections. Single-dose treatments comprising steroids, antifungals and antibacterials are known. [0003] Multiple bolus treatments, local and systemic, are currently used to treat the above skin inflammations. Compositions for the treatment of local and systemic inflammation typically use a combination of corticosteroids as an essential compo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/137A61K31/41A61K31/496A61K31/56A61K31/575A61K9/00A61P17/00
CPCA61K31/41A61K31/575A61K31/496A61K31/56A61K31/4174A61K45/06A61K31/58A61K9/0014A61K31/573A61K31/137A61K9/06A61P17/00A61P29/00A61P31/04A61P31/10A61K2300/00
Inventor 苏鲁·苏布拉马尼·瓦南加穆迪马达范·斯里尼瓦桑尼拉坎丹·纳拉亚南·许利耶尔巴尔克里什南·塞尔瓦拉贾
Owner 苏鲁・苏布拉马尼・瓦南加穆迪
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