Preparation method of Bazheng mixture

A mixture, diaphragm filter press technology, applied in the directions of medical preparations, drug combinations, pharmaceutical formulations containing active ingredients, etc., can solve the problems of easy loss of heat-sensitive ingredients, low recovery rate of active ingredients, troublesome post-processing, etc., to achieve environmental benefits. The effect of protection, good clarity and improved extraction efficiency

Active Publication Date: 2013-08-21
TAIJI GRP CHONGQING FULING PHARM FACTORY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the above methods, the active ingredients of the prescription medicinal materials are extracted by the dipping method, the percolation method and the decoction method respectively, which have the disadvantages of cumbersome process, long extraction time, high extraction temperature, high energy consumption, easy loss of heat-sensitive ingredients, low recovery rate of active ingredients, and post-processing. Disadvantages such as handling trouble

Method used

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  • Preparation method of Bazheng mixture

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Prescription: Qumai 5.9kg, Stir-fried Plantain 900g, Cucumber 5.9kg, Rhubarb 5.9kg, Talc 5.9kg, Akebia 5.9kg, Gardenia 5.9kg, Licorice 5.9kg, Rush 2.95kg

[0036] The preparation method comprises the following steps:

[0037] a. Roasted Psyllium and Rhubarb Extract

[0038] a1. Mix the fried plantain seed and rhubarb in the prescribed amount, crush them into coarse powder, and set aside;

[0039] a2. Add 40% ethanol equivalent to 7 times the total weight of fried plantain seeds and rhubarb into the batching tank; switch the three-way valve to the batching tank position, turn on the agitator, diaphragm pump and diaphragm filter press of the batching tank, and turn the batching tank The 40% ethanol in the medium is pumped into the membrane filter press (using 5-8 L / m 2 .s polypropylene multifilament filter cloth), until the filtrate returns to the batching tank, add the powder obtained in step a1 into the batching tank at a constant speed, after the addition, the mem...

Embodiment 2

[0047] Prescription: Qumai 5.9kg, Stir-fried Plantain 900g, Cucumber 5.9kg, Rhubarb 5.9kg, Talc 5.9kg, Akebia 5.9kg, Gardenia 5.9kg, Licorice 5.9kg, Rush 2.95kg

[0048] The preparation method comprises the following steps:

[0049] a. Roasted Psyllium and Rhubarb Extract

[0050] a1. Mix the fried plantain seed and rhubarb in the prescribed amount, crush them into coarse powder, and set aside;

[0051] a2. Add 40% ethanol equivalent to 8 times the total weight of fried plantain seeds and rhubarb in the batching tank; switch the three-way valve to the batching tank position, open the agitator, diaphragm pump and diaphragm filter press of the batching tank, and turn the batching tank The 40% ethanol in the medium is pumped into the membrane filter press (using 5-8 L / m 2 .s polypropylene multifilament filter cloth), when the press filtrate flows back into the batching tank, add the medicinal powder obtained in step a1 into the batching tank at a constant speed, after the ad...

Embodiment 3

[0059] Prescription: Qumai 5.9kg, Stir-fried Plantain 900g, Cucumber 5.9kg, Rhubarb 5.9kg, Talc 5.9kg, Akebia 5.9kg, Gardenia 5.9kg, Licorice 5.9kg, Rush 2.95kg

[0060] The preparation method comprises the following steps:

[0061] a. Roasted Psyllium and Rhubarb Extract

[0062] a1. Mix the fried plantain seed and rhubarb in the prescribed amount, crush them into coarse powder, and set aside;

[0063] a2. Add 40% ethanol equivalent to 6 times the total weight of fried plantain seeds and rhubarb into the batching tank; switch the three-way valve to the batching tank position, turn on the agitator, diaphragm pump and diaphragm filter press of the batching tank, and turn the batching tank The 40% ethanol in the medium is pumped into the membrane filter press (using 5-8 L / m 2 .s polypropylene multifilament filter cloth), when the press filtrate flows back into the batching tank, add the medicine powder obtained in step a1 into the batching tank at a constant speed, after th...

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Abstract

The invention discloses a preparation method of a Bazheng mixture. The preparation method utilizes a diaphragm press filtration cycle extraction separation integrated technology to replace the existing immersion technology, the percolation technology and the decoction technology so as to extract active ingredients from prescription drugs, and thus the preparation method simplifies a process flow,shortens greatly a production period, saves energy consumption, is beneficial for environmental protection and greatly improves a recovery rate of active ingredients. Through adopting ultrafiltrationmembrane direct filtration to replace standing and filtration in preparation steps, the preparation method solves thoroughly the quality problem that a finished product produces precipitates easily and thus the finished product cannot satisfy mixture related requirements wherein the produced precipitates do not disappear through shaking, and shortens further a production period.

Description

technical field [0001] The invention belongs to the field of pharmacy and relates to a preparation method of a traditional Chinese medicine preparation. Background technique [0002] The Chinese Pharmacopoeia 2010 edition one records: Bazheng Mixture has the effects of clearing away heat, diuresis and relieving stranguria, and it is clinically used for damp-heat injection, short red urine, phlegm, astringent pain, dry mouth and throat. The prescription is 118g Qumai, 18g fried plantain seed, 118g rhubarb, 118g talc, 118g akebia, 118g gardenia, 118g licorice, and 59g rush. The preparation method is to impregnate the plantain seeds with 25% ethanol, and collect the impregnation solution; use 50% ethanol as a solvent for the rhubarb, soak it for 24 hours, then carry out percolation, collect the percolation solution, and recover the ethanol under reduced pressure; Boil three times, filter, combine the filtrate, concentrate the filtrate to about 1300ml, combine with the soaking ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/88A61P7/10A61P13/00A61K33/12
Inventor 冯天炯张运伟彭爱国
Owner TAIJI GRP CHONGQING FULING PHARM FACTORY CO LTD
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